Head of Business Development Europe for early drug discovery services from hit discovery to Lead including cell-based and biochemical assay development, HTS (High-Throughput screening) and Hit follow-up activities
Studying drugs' effects on organoids.... We are excited to announce a research collaboration between Axxam, a leader in Screening technologies and High Content Imaging, and Tessara Therapeutics, renowned for their expertise in creating #humanBrainOrganoids. Together, we develop complex cellular models of co-cultured human neurons and glial cells in microplate formats for image-based analysis using High Content Screening microscopy (Opera Phenix by Revvity). Our collaboration exemplifies the power of combining cutting-edge imaging technology with advanced organoid models to push the boundaries of neuroscience research. 🎥 Check out our latest movie, showcasing a 3D reconstruction of a brain organoid in a miniaturized format. The first seconds provide a maximum projection overview, followed by a detailed representation of the volumetric structure of part of the organoid (left) and a magnified region with higher resolution (right). The green color highlights the β-III tubulin staining for neurites, while the red color indicates the signal from glial cells. This cell culture system can be utilized to test the effects of drugs on human neuronal disease models, providing critical insights into neurogenesis and neuroplasticity within a organ-like context. The use of organoid systems will allow to pharmacologically interrogate yet unprecedented biology. Stay tuned for more updates on our research and the future of drug discovery! #Axxam #TessaraTherapeutics #HighContentImaging #BrainOrganoids #Neuroscience #Innovation #DrugDiscovery #RealBrain
