Kathy Fraser’s Post

Elevated coronary heart diseases risk attributed to clonal haematopoiesis of indeterminate potential was nonnegligible even for small clones (variant allele fraction 0.5-2%) & could be compensated by germline genetic risk, especially in inflammatory genes. https://ja.ma/3IDAcpf

Elevated coronary heart diseases risk attributed to clonal haematopoiesis of indeterminate potential was nonnegligible even for small clones (variant allele fraction 0.5-2%) & could be compensated by germline genetic risk, especially in inflammatory genes. https://ja.ma/4aKVCh7

Association between CYP4A11 and EPHX2 genetic polymorphisms and chronic kidney disease progression in hypertensive patients https://lnkd.in/dEDdF9a5

“Autoimmune diseases are multifactorial and include environmental as well as genetic drivers. Although much progress has been made in understanding the nature of genetic underpinnings of autoimmune disease, by comparison much less is understood regarding how environmental factors interact with genetics in the development of autoimmunity and autoimmune disease. In this report, we utilize the (New Zealand black × New Zealand white [NZB × NZW]) F1 mouse model of systemic lupus erythematosus (SLE). Mercury is a xenobiotic that is environmentally ubiquitous and is epidemiologically linked with the development of autoimmunity. Among other attributes of human SLE, (NZB × NZW) F1 mice spontaneously develop autoimmune-mediated kidney disease. It has been previously shown that if (NZB × NZW) F1 mice are exposed to inorganic mercury (Hg2+), the development of autoimmunity, including autoimmune kidney pathology, is accelerated. We now show that in these mice, the development of kidney disease is correlated with a decreased percentage of marginal zone (MZ) B-cells in the spleen. In Hg2+-intoxicated mice, kidney disease is significantly augmented, and matched by a greater decrease in MZ B-cell splenic percentages than found in control mice. In Hg2+- intoxicated mice, the decrease in MZ B-cells appears to be linked to aberrant B-cell receptor signal strength in transitory 2 (T2) B-cells, developmental precursors of MZ B-cells.”—From a #ToxSpotlight article by Randall F. Gill et al. in the February 2024 issue of Toxicological Sciences. https://bit.ly/3HDU1w7 #FreeToRead

Newly discovered genetic markers help pinpoint diabetes risks, complications . In the largest genome-wide association study to date on Type 2 diabetes, a team of international researchers has located 1,289 genetic markers associated with Type 2 diabetes (145 of which are newly identified) and generated risk scores for diabetes complications. #ScienceDailynews #InnovativeResearch #NextGenScience #ExploringFrontiers

A recent retrospective study conducted at the inherited retinal disease (IRD) clinic at the University of Minnesota Health System sheds light on the clinical characteristics and genetic variants present in a cohort of Leber congenital amaurosis (LCA) patients. View the complete article below ⤵️ #inheritedretinaldisease #eyedisease #genetictesting

More common than you might think: Cystic Fibrosis It affetcs over 40,000 Americans and over 100,000 people across the world, making it one of the most frequent genetic diseases. 👉 Learn more in our blog: https://nddmed.co/zrz75g #ndd #CysticFibrosis #EarlyDiagnosis #Spirometry

Primary hyperoxaluria (PH) encompasses a group of rare genetic disorders marked by the overproduction of oxalate, leading to severe complications such as end-stage renal disease (ESRD). Read the full article here ⤵️ #Kidney #Genetics #PrimaryHyperoxaluria

News from Veterans Health Today: Platelet reactivity can be predicted from complete blood count scattergrams generated by widely used hematology analyzers, according to a report in the journal Blood. Learn more about how researchers used the method to investigate genetic determinants of platelet reactivity and causal associations with thrombotic disease. #VeteransHealthToday #VHT #VAHealthcare #VANews #plateletreactivity #thromboticdisease

🔔 Wednesday reading recommendation!-Vol. 16 No.1 📌 The Relationship between Mitochondrial Genome Mutations in Monocytes and the Development of Obesity and Coronary Heart Disease ✒ By Taisiya V. Tolstik；Tatiana V. Kirichenko；Anastasia I. Bogatyreva；Yuliya V. Markina；Vladislav A. Kalmykov；Alexander M. Markin 🖇 https://lnkd.in/ekgEj3D9 🔑 Keywords: mtDNA mutations；monocytes；inflammation；mitochondria；cardiovascular diseases 😎Welcome to your reading! #mtDNAmutations #monocytes #inflammation #mitochondria #cardiovasculardiseases #Genetics #Heredity