Kelath Murali Manoj’s Post

Kelath Murali Manoj's response to Cyrus Khojasteh, Senior Director at Genentech, in response to his "compliment" to the assembly of "pseudo-professionals" of the ISSX meeting coming up!! (I have to call them so, because they do not consider evidence and publications that counter their line of thinking! This is not a matter of choice, it is a professional/moral obligation!!) My Frontiers in Pharmacology (2016) paper lists 50 distinct unassailable points that ESTABLISHED why the classical approach to xenobiotic/drug metabolism is flawed and murburn model explains liver metabolism mediated by CYPs-CPR. (https://lnkd.in/gkqdyGJZ) Further, my group's published works are in mainstream journals like PLoS One, BBRC, Dose Response, and CDM. Not only that, now murburn model is established for mitochondrial redox phosphorylations too! See the latest of my talks here: https://lnkd.in/gsgXaC-4 (from 37th minute). The findings pose profound impact on lead-drug optimization, understanding dose responses, drug-drug interactions and pharmacokinetics. I had spent thousands of dollars from my own pocket to come to USA and presented my works to you folks on CYP-CPR metabolism in GRC and ISSX conference in 2015. What good was my presentation to you folks at Genentech before this year's GRC? I had requested for attention with your organizers and didn't get it, and then made scenes with the leaders at the ISSX meeting in 2015 (Florida) so that your leadership feathers would be ruffled. It didn't. How thick-skinned are you folks?? The so-called prestigious GRC is a FARCE! I was disciplined by Mike Zientek of Pfizer (Chair) for trying to reach out (by email) to fellow researchers with my findings at the venue, when the advertisement had proclaimed that one could freely interact with attendee researchers! Your all-star line-up is a serious joke! Your complementing each other, disregarding the murburn model of xenobiotic/drug metabolism is deplorable. I must say it is a great disservice you folks do to the public and to yourselves. You all will go down in history, with this attitude. (Including the pioneering stalwarts like Coon, Guengerich, Ortiz de Montellano, Sligar, etc.!) Keep such meetings at exotic places, go there, eat-drink and form consensus that don't make any sense to us, and just go on patting each others back when the winds of change had already blown! I have all the evidence to show for all of my claims. It's a sham(e)!! I hate to do this (casting aspersions on associations/institutions), but you folks (and your leaderships) leave me no options and now, I have to do this.