📢 Conscience has released the results of CACHE Challenge #1, which aimed to predict "hits" for Parkinson's disease drugs through computational models. Conducted in partnership with The Structural Genomics Consortium (SGC) and funded by The Michael J. Fox Foundation for Parkinson's Research, the challenge has yielded seven promising discoveries for familial Parkinson's disease. The CACHE Challenge has two key outcomes: firstly, new discoveries that can help advance novel treatments for Parkinson’s disease, and secondly, prospective benchmarking of multiple computational methods to reveal the state-of-the-art and guide future progress. Conscience has now made the entire experimental dataset of the CACHE Challenge available to the public, including the chemical structures of all the molecules tested and associated computational methods. #Conscience #CACHEChallenge #ParkinsonsDisease #DrugDiscovery #ComputationalModels #OpenScience
Kelsey Merkley’s Post
More Relevant Posts
-
A multi-layered computational structural genomics approach enhances domain-specific interpretation of Kleefstra syndrome variants in EHMT1. Read the article here: https://lnkd.in/gXqUZ-nF
-
This Mission Continues at IndyGeneUS AI!!! This is a major step towards future research studies that will address misdiagnosis of endometriosis, uterine fibroids and PCOS in underrepresented women populations globally. Understanding these conditions at the molecular level will be critical. Extremely honored that IndyGeneUS AI got to work with all the co-authors of this published paper. #genomics #diversitymatters #womenshealth #indygeneus
We are very proud to announce our first paper has been accepted for publication using Digital Twins and Genomics: “The Application of Knowledge Engineering via the use of a Biomimetic Digital Twin Ecosystem, Phenotype Driven Variant Analysis, and Exome Sequencing to Understand the Molecular Mechanisms of Disease.” Authors and affiliations: William G. Kearns (Co-founder/CEO and Chief Scientific Officer of Genzeva and LumaGene); J. Georgios Stamoulis (QIAGEN Digital Insights); Joseph Glick and Lawrence Baisch (RYLTI BioPharma); Andrew Benner, Dalton Brough, Luke Du (Genzeva); Bradford Wilson (IndyGeneUS AI); Laura Kearns (Genzeva and LumaGene); Nicholas Ng, Maya Seshan, and Raymond Anchan (Brigham and Women’s Hospital, Harvard University). Running Title – Digital Twins and Molecular Medicine.
-
-
Looking for PhD position | Molecular Biologist|Researcher|Computer aided drug discovery
🔬 **Revisiting Telomere Biology: Unveiling the Dual End-Replication Problem** 🔬 Half a century ago, the discovery of telomeres by scientists Jim Watson and Alexey Olovnikov shed light on a fundamental puzzle: how our DNA gets copied accurately during replication. The subsequent identification of telomerase by Liz Blackburn and Carol Greider seemed to solve the mystery. However, new research published in Nature challenges this conventional wisdom, revealing a deeper complexity. Recent findings suggest not one, but two end-replication problems, intricately tied to the replication of both strands of DNA. While telomerase was known to address the leading-strand problem, it turns out another molecular complex, CST-Polα-primase, tackles the lagging-strand issue. The leading-strand problem arises because the DNA replication machinery fails to fully duplicate the telomere, leaving it with a blunt leading end. Telomerase adds repeats to solve this issue. However, Hiro Takai's discovery revealed a surprising lagging-strand problem: the replisome cannot fully synthesize the lagging strand, leading to further telomere shortening. Joseph T. P. Yeeles' in vitro experiments confirmed this, showing that the replisome stops lagging-strand synthesis before reaching the 5' end. This revelation challenges previous models of telomere replication and necessitates a reevaluation of our understanding of telomere biology. Takai's subsequent in vivo assays further confirmed these findings, shedding light on how CST-Polα-primase replenishes repeats to maintain telomere integrity. This newfound understanding not only revises textbooks but also holds clinical significance. Mutations in CST-Polα-primase are associated with telomere disorders like Coats plus syndrome. By unraveling the intricacies of telomere maintenance, this research opens doors for potential therapeutic interventions in addressing these devastating disorders. In essence, this study marks a significant step forward in our comprehension of telomere biology, highlighting the complexity of DNA replication and its implications for human health. #TelomereBiology #DNAReplication #MedicalResearch 🧬✨
-
-
Bioinformatician | Freelancer | NGS Data Analysis | Genomics | Computer aided Drug Discovery
🔬 Deep Dive into Single-Cell and Spatial Multi-Omics! 🧬 Just explored an insightful review on the latest advancements in single-cell and spatial multi-omics. It focuses on the technological and computational principles, current state of the art, and the applicative value of these modern methods. The article delves into how these methods provide a comprehensive view of at least one molecular analyte and highlights the importance of data integration for maximizing the potential of multi-omics technologies. The article discusses the impact of these technologies on cell biology and translational research, including a glimpse into the future of personalized medicine! #Bioinformatics #Genomics #SingleCell #SpatialOmics #TranslationalResearch
-
🌿 Exciting Breakthrough in Molecular Biology! Unveiling Fennel miRNAs for the First Time! 🧬 Thrilled to share a groundbreaking discovery from our research team! For the first time, we have uncovered a set of unique fennel miRNAs that hold incredible promise for advancing our understanding of human biology. 🌐 🔍 Key Findings: These fennel miRNAs demonstrate a fascinating ability to interact with human genetic materials, significantly influencing gene expression and cellular functions. Preliminary results indicate potential implications for crucial biological pathways, offering new perspectives on therapeutic interventions and human health. 🌱 Fennel's Hidden Secrets: Who would have thought this humble herb could harbor profound insights into our molecular makeup? Nature continues to surprise us, emphasizing the importance of exploring diverse molecular landscapes. 🚀 The Future of Biomedical Research: As we delve deeper into the implications of these miRNAs, we are optimistic about unlocking novel avenues for therapeutic development and pushing the boundaries of our knowledge in molecular biology. 🤝 Collaboration and Exploration: Excited to collaborate with fellow researchers and professionals in the field! Let us continue pushing the boundaries of what we know and exploring the potential applications of this groundbreaking discovery. The article is available at https://lnkd.in/dNU7szc9 #BiomedicalResearch #MolecularBiology #ScientificDiscovery #FennelmiRNAs #HealthInnovation #Bioinformatics
-
-
Associate Professor - European University Cyprus; School of Medicine / Doctor of Philosophy - PhD at Harvard University
New and exciting methods to capture genetic information!
A new method, called Slide-tags, lets scientists capture both genetic and location information of individual cells using standard single-cell workflows in the lab. The technology builds on Slide-seq, and both were developed by the labs of Fei Chen and Evan Macosko. Slide-seq can map spatial patterns of genetic activity within tissues, but doesn’t reach single-cell resolution like the new Slide-tag method. #BroadInstitute #Science #ScienceNews #ScientificResearch #Research
New method tags cells with location coordinates for single-cell studies
broadinstitute.org
-
Understanding the information within our cells has been one of the primary focuses of the scientific community in the past decade. Now, thanks to Slide-tags, it has become possible to trace the genetic details and location information at a resolution as specific as the single-cell level.🤔🤔 Check this out‼️‼️👇🏻
A new method, called Slide-tags, lets scientists capture both genetic and location information of individual cells using standard single-cell workflows in the lab. The technology builds on Slide-seq, and both were developed by the labs of Fei Chen and Evan Macosko. Slide-seq can map spatial patterns of genetic activity within tissues, but doesn’t reach single-cell resolution like the new Slide-tag method. #BroadInstitute #Science #ScienceNews #ScientificResearch #Research
New method tags cells with location coordinates for single-cell studies
broadinstitute.org
-
Advances in genomics and molecular biology led to the growth of precision medicine, where treatments and interventions were tailored to an individual's genetic makeup. This approach aimed to improve the effectiveness of treatments and reduce side effects. #MerakiHealthcare #MedicalRevenueCycle #Medicalservice #USA #WellnessWealth #PrecisionMedicineBilling #GenomicsBilling #MedicalBillingInnovation #BillingSolutions #PrecisionHealthcare #AdvancedMedicalBilling #GenomicHealthcare
-
-
Neurotechnology and AI are moving brain diseases to the next stage of health solutions
Today we publish in PLOS Computational Biology a new technology for integrating complex biological and clinical information using multiscale networks. We have applied it to the case of Multiple Sclerosis, founding paths linking genes, proteins, cells, and imaging with the clinical phenotype. Next, we are applying it to the case of Alzheimer disease. #ms #networks #systemsbiology https://lnkd.in/dQ2dk86c
Multiscale networks in multiple sclerosis
journals.plos.org
-
🔬 Molecular chemist Alice Ting and her team at Stanford University have devised a new tagging system that enables scientists to track protein traffic in living cells. This new method, dubbed "TransitID," was detailed in a paper published in Cell Press in 2023. 🇹🇼 Born in Taiwan, Ting received The Vilcek Foundation Prize for Creative Promise in Biomedical Science in 2012 for the development of sophisticated tools for the detection and visualization of individual biomolecules. 🔗 Read more on Ting's research and the potential for TransitID in the following article from Stanford University. #BiomedicalResearch #BiomedicalScience #DiversityinScience #DiversityinSTEM #Stanford #StanfordUniversity #WomeninScience #WomeninSTEM
Stanford University Scientist Alice Ting has developed a new method to track proteins in living cells.
https://news.stanford.edu
Collaborative Operations Leader | Scaling Organizations & Experiences | Trusted Advisor to Visionary Founders | AI Enthusiast
7moThis is an awesome initiative. The former scientist in me loves this so much - going to take a look and see if there's ways to support their projects.