Thinking of applying for SBIR and STTR funding for your small business in translational science? Check out the recordings of past informational webinars, hosted in collaboration with a variety of partners: go.nih.gov/YjOUAWb#NCATSsbir#smallbiz
A nice milestone (200 reads and counting.....) for our paper investigating the subcellular dynamics of the enigmatic human GnRH (Gonadotropin-releasing Hormone) receptor. A huge thanks to everyone who has taken the time to read our work.
#receptor#gpcr#GnRH#internalizaton#dynamics#endocytosis
BIO-TECHNE ANNOUNCES NEXT-GENERATION HIGH THROUGHPUT SIMPLE WESTERN SYSTEM
MINNEAPOLIS, July 31, 2024 /PRNewswire/ --
Bio-Techne Corporation (NASDAQ: TECH) is pleased to announce the launch of the Leo™ System.
This next-generation Simple Western™ instrument offers higher throughput, flexibility, and efficiency over the current Jess™ and Abby™ Simple Western Systems.
This state-of-the-art instrument enables simultaneous processing of up to 100 samples in a single 3-hour run, allowing scientists to process more samples in a day. Leo also provides 4-times the experimental size of Jess or Abby to facilitate #quantitative assay designs including standard curves, QC samples, blanks, duplicates and reference standards.
Leo’s enhanced quantitative capabilities empower customers to design rigorous bioanalytical methods for use throughout the #drugdevelopment process and in submissions to regulatory agencies.
Simple Western instruments are fully automated, capillary western systems designed to resolve proteins based on molecular weight followed by immunodetection. Simple Western Systems replace traditional western blotting workflows by offering improvements in data quality and speed.
The enhanced #quantitation, #reproducibility and #throughput Leo now provides makes it possible for scientists to adopt western-based readouts in applications where westerns are not typically used due to inadequate reproducibility and lack of quantitation.
Leo offers ELISA-like protein quantitation with the specificity and size resolution of western blotting, enabling new applications for western-based assays ranging from #targetscreening & #validation, #targetedproteindegradation, #genetherapy#potencyassays, #clinicalbiomarkeassays, and #vaccinedevelopment.
"The upcoming introduction of the Leo System reaffirms Bio-Techne's commitment to advancing protein analysis technology. The ability to perform western analysis at this scale is truly game changing and will allow the adoption of Leo as a quantitative immunoassay platform in all stages of drug development and commercialization," commented Will Geist, President of Protein Sciences.
Leo is expected to begin shipping in calendar year 2025.
Get a first look at the Leo System and explore its capabilities here:
Meet Leo - The Next Leap in Simple Western Technology
https://lnkd.in/gJ3KD2Mz
For more information, feel free to book a meeting.
#biotechne#leo#automatedsolutions#workflowsolutions#reproducibility#quantitativeresults#westernblot#elisa
We are very proud to announce that #HIRI department head and European Research Council (ERC) grantee Chase Beisel received an #ERCPoC! Congratulations! 🎉
As part of an #ERCCoG project, the team led by Beisel, who also holds a professorship at The Julius Maximilians University of Würzburg, is researching #CRISPR-Cas systems. The researchers identified a new mechanism that kills unmodified cells while sparing modified ones. In the now-funded project, Beisel will conduct proof-of-concept experiments.
If successfully developed, the method could simplify the generation of cell-based therapies and accelerate the generation of edited cells for studying the mechanistic basis of human diseases. Learn more at: https://lnkd.in/eZasa3sg
The method relies on the #Cas12a2 nucleases that the Beisel lab recently characterized together with Benson Hill, Inc. (Missouri) and Utah State University in the U.S.: https://lnkd.in/eQd6iuij
My first ever Kaggle competition participating with Hoa Nguyen and Nicolas Bolik-Coulon, PhD.
The objective of this competition is to develop a machine-learning model to predict DNA-encoded compounds interacting with 3 different therapeutic targets. The main challenge is to predict the molecules with different scaffolds/ building blocks from the training sets, thus testing the ability to generalize the model.
Our team finished in 121st position (out of 1,946 participating teams) with a bronze medal. Our model was based on 1D CNN combined with Xgboost classification and data augmentation by bioisostere replacement.
It was a very eye-opening journey. The discussions and shared notebooks from the participants were very informative and taught me a lot about different techniques for encoding small molecules and optimizing various machine-learning models.
As discussed by Hoa Nguyen, this competition also highlighted the limited generalization of machine learning models for different classes of molecules, which I believe is due to the massive scale of the chemical space. This makes me think that assays like NMR, which can provide information about the binding epitope, can be very beneficial in this case.
ASCB Emerging Concepts--These Are No Ordinary Virtual Meeting!
ASCB’s Emerging Concepts series brings you new research from leaders working on the latest cutting-edge topics in cell science, in a highly interactive online format that helps attendees form new connections and collaborations.
Upcoming Events:
- March 19, 2024: Structural Cell Biology in the Nervous System
- April 11, 2024: Cellular Rejuvenation
During these events you’ll:
- Hear from leading experts at the forefront of their fields—and you’ll be able to network with them too.
- Come away with new ideas that can inspire your own work.
- Have an opportunity to showcase your own work and receive valuable feedback via 5-minute talks and Q&As. Submit an abstract now.
- Engage in small table discussions where you can meet and interact with colleagues in an intimate setting that allows for real discussions.
Learn more: https://lnkd.in/gbupF3-y
If you're attending #ACMGMtg24, please don't miss this talk featuring data analytics for Twist Bioscience Exome + CNV Backbone Panel -
"UNLOCKING GENETIC MYSTERIES: MASTERING EXOME ANALYSIS WITH VSCLINICAL & VS-CNV"
Friday, March 15th, 11:20am, Theater 2
Presented by: Nathan Fortier, Director of Research at Golden Helix, Inc.
This talk will be discussing the sensitivity rate for the detection of known CNV events at all three probe densities, the impact of best-practice quality metrics and filters on sensitivity, how VarSeq’s CNV annotation capabilities can be leveraged to identify likely pathogenic CNVs, and the interpretation of clinically relevant CNVs using VSClinical.
Add to Calendar: https://shorturl.at/egBO1https://lnkd.in/gMQ9tzQp#MedicalGeneticsAwareness
💻 Unlocking Cell Secrets with QPI 🔬 🦠
In this webinar, Tomáš Groušl from the Institute of Molecular Genetics of the Czech Academy of Sciences and our application specialist Aneta Křížová focused on the use of Quantitative Phase Imaging (QPI) to examine cell morphology alterations influenced by the RACK1 protein. We also welcomed Věra Chválková, who presented her research on the impact of RACK1-depleted protein on MDCK cells, originating from dogs’ kidneys.
A comprehensive overview of QPI technology's capabilities and applications in cellular research 👇
#telight#microscopy#webinar#qpi#qphase
Looking out for research enthusiasts! If you're interested in Basic Research, please let me know in the comments, and I'll share the basic one. Have a good day!
#research#usmle#img
