Kojin Therapeutics’ Post

We are coming to Immunology 2024 organized by The American Association of Immunologists from May 3rd to May 7th, 2024. Don't forget to attend Hanna van Ooijen's poster on our recently published Application note. Title: Molecular Pixelation: Spatial proteomics of single-cells by next generation sequencing Presentation Date: 5/5/2024, 3:15 PM – 4:30 PM CT Poster Number: B916 #spatialbiology #tcell #Tcellactivation #Immunology2024 #Immunology #Spatialproteomics #proteomics #nextgenerationsequencing

Discover novel technologies for fluorescent cell labeling at our November 14th webinar on high throughput compatible activation induced marker assays. We will discuss the two phases of data generation used by the Allen Institute for Immunology: the development of high dimensional, highly robust protocols for immune cell interrogation by flow cytometry and single cell genomics (phase 1) and lower dimension image cytometry, high-throughput and automation compatible assays (phase 2). Gain tools to optimize your workflows using an array of technologies to minimize user error. Register today! BioLegend

🔬 CanCellVar: Single-Cell Cancer Variants database! 🧬 Recently published on "CanCellVar: A database for single-cell variants map in human cancer" in The American Journal of Human Genetics by Changbo Yang, Yujie Liu, Chongwen Lv, and colleagues. ⚠️ Highlights ⚠️ 📊 2,896,201 variants, including ~1.4 million SNVs and ~1.4 million A>G RNA edits, across 2,754,531 cells from 37 cancer types. 🎯 Variants identified using scRNA-seq data, filtering out germ-line mutations to annotate somatic variants. 🛠️ Analysis Modules including variant fraction analysis, cell trajectory construction, and more, supporting drug sensitivity and gene expression studies. 📚 AJHG paper: https://lnkd.in/dqdQs4MV 🌐 Database website: https://lnkd.in/djXatvzE 📢 Join the Conversation 📢 Share your ideas, methods, and tools in the comments! 👇 💬 #CancerResearch #SingleCellGenomics #Bioinformatics #CanCellVar #Oncology #Genomics #DataScience

📢Advance Your Career with CEB’s Specialized (Molecular Oncology Program). Join our Molecular Oncology Program at CEB, designed to equip you with the knowledge and tools necessary to deeply understand this complex disease. This specialized course offers the latest insights and advancements in cancer detection, diagnosis, and cutting-edge treatment options✅ Our comprehensive content includes👇 1. Understanding cancer epidemiology, symptoms, and types. 2. Exploring the role of molecular biology in cancer diagnosis and treatment. 3. Studying key genes whose mutations contribute to cancer, such as Ras, P53, and FLT3. 4. Examining tumor suppressor genes like BRCA1and BRCA2. 5. Identifying gene expressions associated with drug response. 6. Discovering prognosis-relevant genes. 7. Learning targeted mutation detection in clinical cancer settings using Formaldehyde fixed  paraffin embedded (FFPE) tumor tissue. Finally ,We have exclusive opportunities for you 🤩 1. Special Day at the National Research Center: Enhance your hands-on lab skills with a visit to the NRC, where you'll work directly with tissues in a practical, real-world setting🥼🔬 2. Limited-Time Offer: Enjoy a 10% discount on enrollment. Seats are filling up fast secure your spot today⏳ For registration and more details contact me💜📝 #ceb #molecularoncology

At 3BIGS, we understand the critical importance of harnessing data to drive advancements in cancer research and treatment. That's why we've developed a powerful platform equipped with cutting-edge features to empower researchers, clinicians, and decision-makers in the fight against cancer. Are you attending the upcoming PrecisionMed conference? Make sure to stop by Booth D17 and discover more about Cancer Insights platform. Here are just a few key features of our Cancer Insights platform: 🔍 Survival Probability Analysis: Dive deep into survival rates and prognostic factors, enabling informed decision-making and personalized treatment strategies. 🧬 Gene-Disease-Drug Network Analysis: Uncover intricate relationships between genes, diseases, and drugs, unlocking insights into potential therapeutic targets and novel treatment approaches. 🔬 Gene Mutation Analysis: Explore genetic mutations associated with different types of cancer, facilitating the discovery of biomarkers and the development of targeted therapies. 📊 Visualize Multiple Omics Information: Seamlessly integrate and visualize diverse omics data, including genomics, transcriptomics, proteomics, and more, to gain comprehensive insights into cancer biology. But that's not all! Our booth(D17) will be buzzing with insightful discussions, and opportunities to connect with fellow professionals in the field. Don't miss your chance to join the conversation and explore the endless possibilities with Cancer Insights. Hope to see you at our booth D17 #3BIGS #CancerInsights #Bioinformatics #Healthcare #DataScience  #precisionmedicine #pmes2024 #genomics #genetics #health #exhibition

Nuclei Webinar 15 | Exporting In this clip, Ben demonstrates how to easily export results from the CellDrop Automated Cell Counter. "Optimizing Nuclei Extraction & Counting for Single Cell Sequencing" is available to watch on-demand! Watch now: https://buff.ly/45yLYuK #LifeScience #Laboratory #Microbiology #CellBiology #CellCulture #LaboratoryEquipment #Immunology #CancerResearch #FlowCytometry #Webinar

💡 The article, titled "SMAD7 expression in CAR-T cells improves persistence and safety for solid tumors", was published in Cellular & Molecular Immunology. This study co-expressed SMAD7, a suppressor of TGF-β signaling, with a HER2-targeted chimeric antigen receptor (CAR) in engineered T cells.   🧬SMAD7 substantially reduced the production of inflammatory cytokines by antigen-primed CAR-T cells. Mechanistically, SMAD7 downregulated TGF-β receptor I and abrogated the interplay between the TGF-β and NF-κB pathways in CAR-T cells.   🧬SMAD7 co-expression also enhanced CAR-T-cell infiltration and persistent activation in patient-derived tumor organoids.   Therefore, this study demonstrated the feasibility of SMAD7 co-expression as a novel approach to improve the efficacy and safety of CAR-T-cell therapy for solid tumors.   🔬 BMKGENE provides transcriptome sequencing and bioinformatics analysis services for this study.   #CAR-T #TME #TGF-β #SMAD7 #SolidTumors #RNAseq #Bioinformatics

Proteomics was one of the key global opportunity areas for diagnostics that my team highlighted as part of our strategic technology roadmap for the UK IVD industry. Proteomics has been around as long as genomics, but has not as readily translated into routine clinical use. Findings such as that in the paper below, work from the University of Oxford with O-Link Proteomics and the UK Biobank, give real hope for a new era of discoveries to power the future of cancer diagnostics within proteomics: “182 proteins that may be used for early detection were identified - associated with diagnosis within three years, suggesting potential relevance as biomarkers for early detection” https://lnkd.in/eMYB8X4B

I am honored to serve as a guest editor with Valentina Capo and Francesca Pala, for the research topic “B-cell Engineering in Malignant and Non-Malignant Disease” in Frontiers in Immunology! This research topic aims to delve into the field of B-cell engineering, which is transforming our approach to both malignant and non-malignant diseases. As we witness the emergence of novel therapeutic strategies, understanding the intricate role of B cells in the immune response has never been more critical. 🔬 Key Areas of Focus: - Advances in B-cell engineering technologies - Mechanistic insights into B-cell behavior in disease contexts - Innovative applications of B-cell therapies in clinical settings We invite researchers and experts from various disciplines to contribute their cutting-edge work, fostering a collaborative environment to enhance our understanding of B-cell functions and therapeutic potentials. 📅 Manuscript Summary Submission Deadline: 12/05/2024 📅 Manuscript Submission Deadline: 03/25/2025 For more details and submission guidelines, please visit the link below: https://lnkd.in/e5TrRzRM

Discovering the B-NDG Mouse Model for Advanced Research Our independently engineered B-NDG mouse model features severe immunodeficiency through targeted IL2rg gene deletion in the NOD-scid genetic background. Ideal for engrafting human hematopoietic stem cells, PBMCs, and tumor cells, it boasts the highest degree of immunodeficiency, longer lifespan, and minimal rejection of human tissues. Perfect for tumor research, immunology studies, and developing humanized models. Click here to learn more about the B-NDG mouse model: https://lnkd.in/dk-bVEE #Biocytogen #MouseModel #Immunodeficiency #TumorResearch #Hematopoiesis #Immunology #HumanizedModels #BiotechResearch #HealthcareInnovation