Koneksa’s Post

📢 This week, our paper entitled ”Impacts on study design when implementing digital measures in Parkinson's disease-modifying therapy trials” was published online in Frontiers in Digital Health. In this publication we explore the effect that digital health technologies can have on clinical trial study design. We show that compared with quarterly in-clinic assessments, frequent at-home measures for example can reduce the sample size needed to detect a 30% reduction in disease progression from over 300 per study arm to 100 for evenly spaced at-home assessments. Specifically, we get to these results by estimating the test-retest reliability of a suite of at-home motor measures performed using a smartphone device. The estimates are used to simulate digital measures in disease modifying therapy clinical trials. We considered three schedules of assessments and fit linear mixed models to the simulated data to determine whether a treatment effect can be detected. Our results indicate that different derived at-home measures have varying reliability; many have ICCs as high as or higher than MDS-UPDRS part III total score. The results regarding superiority of at-home assessments for detecting change over time are robust to relaxing assumptions regarding the responsiveness to disease progression and variability in progression rates. Read our paper here 👉 https://lnkd.in/e3vPTcRA #digitalhealth #Parkinsons #clinicaltrials

Koneksa is excited to sponsor and attend The Michael J. Fox Foundation for Parkinson's Research PD Therapeutics Conference 2024! We’re proud to be part of this event, dedicated to pioneering and innovative research into Parkinson’s disease. We look forward to collaborating with the incredible minds and advocates leading the charge in this field. Together, we can create meaningful change and hope for those impacted by Parkinson’s. #Parkinsons #Research #Innovation #MJFFConference

Last week, Koneksa’s EVP Data Science Larsson Omberg, Principal Scientist Jennie Lavine and VP Neuroscience Hiromasa Mori Mori attended the 2024 International Parkinson and Movement Disorder Society (#MDS) conference in Philadelphia, where the main theme, “Movement Disorders in the Digital Age: Harnessing AI for Better Lives,” highlighted how digital health technologies are transforming clinical trials and patient care for Parkinson’s. 📖 Read more about their takeaways in our blog here 👉 https://lnkd.in/gVgSy79K #DigitalHealth #AIinHealthcare #MDS2024

Last Chance to Join Us on Oct 16 for Pizza & Insights on Digital Measurements in Parkinson’s Disease! 🍕 👉 RSVP here: https://lnkd.in/eTNwcN-Q Koneksa will be joined by PKG Health, Linus Health and Neuron23 for a seminar exploring the digital measurement technologies that are enabling innovative #Parkinson’s Disease clinical trials. This is an incredible opportunity to connect with leading experts, discover the precision and rich-data provided by #digital sensors and how they are already transforming clinical research. 📅 Date: Wednesday, October 16, 2024 ⏰ Time: 16:30-18:30 (Reception from 16:00) 📍 Location: Koneksa Headquarters at One World Trade Center 🍕 Enjoy pizza and drinks whilst taking in the New York City skyline! This session is open to professionals and researchers involved in Parkinson’s Disease clinical research and drug development. See you there! #Parkinsons #DigitalHealth #DigitalEndpoints #DrugDevelopment #ClinicalTrials

Join Us for a Seminar on Digital Measurements in Parkinson’s Disease on Oct 16 at Koneksa! 🧠 We are excited to announce an exclusive seminar at Koneksa’s headquarters exploring digital measurement technologies that are enabling innovative #Parkinson’s Disease clinical trials. This is an incredible opportunity to connect with leading experts, discover the precision and rich-data provided by #digital sensors and how they are already transforming clinical research. 📅 Date: Wednesday, October 16, 2024 ⏰ Time: 16:30-18:30 (Arrival from 16:00) 📍 Location: Koneksa Headquarters in NYC 🍕 Enjoy pizza and drinks whilst taking in the New York skyline! Key Highlights: - Discussion of the challenges associated with traditional PD clinical endpoints - Technology showcase by Koneksa, PKG Health and Linus Health - Insight from Neuron23 on evaluating and deploying digital measurements This session is open to professionals and researchers involved in Parkinson’s Disease clinical research and drug development. 👉 Register by contacting: neuroscience@koneksahealth.com Note attendees must register interest by October 8, 2024. Limited spaces are available. See you there! #Parkinsons #DigitalHealth #DigitalEndpoints #DrugDevelopment #ClinicalTrials

We're excited to share that Koneksa will be presenting at the upcoming International Congress of Parkinson’s Disease and Movement Disorders. Join us on Sunday, September 29, from 13:00-15:00 in Exhibit Hall A as we present our poster on "Reliability of Digital Measures in Parkinson’s Disease and Their Implications for Sample Size Calculations" (Abstract #1237). Our EVP, Data Science Larsson Omberg and Principal Scientist, Jennie Lavine will be onsite. Come explore how #digital #biomarkers are shaping the future of Parkinson's research. More information: 👇👇 https://lnkd.in/eApwb__C #MDSCongress #ParkinsonsResearch #DigitalHealth #ClinicalTrials

Last week, our VP of Neuroscience Hiromasa Mori rode a whopping 980 miles for Parkinson's UK to raise funds and awareness of Parkinson's Disease. Koneksa is incredibly proud of Hiro's achievement and we're honored to be part of the search for a cure. You can donate to Parkinson's UK here 👉 https://lnkd.in/e6Dntsuk

Our CMO John Wagner, MD, PhD was on a panel on Streamlining Clinical Trials for Patients and Clinicians through Digital at LSX World Congress in Boston. Thanks and great meeting everyone at the event!