Krystal Biotech, Inc.’s Post

The Gene Pulser Xcell System is a flexible, modular electroporation system for transfecting every cell type from primary, suspension, and difficult-to-transfect cells, including T cells, to bacteria and fungi.

From MBoC Mapping Stress-Responsive Signaling Pathways Induced by Mitochondrial Proteostasis Perturbations Wiseman et al. employed gene sets that report on the activity of distinct stress-signaling pathways to monitor the activity of different stress pathways in published Perturb-seq datasets where cells were CRISPRi-depleted of individual mitochondrial proteins. https://lnkd.in/e2-XjvAK

Our new preprint: hemoglobin gene evolution in teleosts and cichlids: fish genomes have many Hb genes (up to 43) diversified from ancestral 7-8 Hb copies. The first step towards understanding #hemoglobin function in Barombi Mbo #cichlids for Dmytro Omelchenko and co-authors! Thanks to everyone involved! https://lnkd.in/eYduEfyc

Did you know? Our study is recruiting patients w/ #ATP1A3 gene variants: https://buff.ly/3EN20Wz We aim to better identify characteristics associated w/ #RDP, #AHC & #CAPOS. We also aim to explore whether variants in the ATP1A3 gene are linked w/ dystonias & #ParkinsonsDisease.

How a Human Starch Gene and a Gut Bacterium are Connected Now scientists have identified a connection between variations in the number of copies of a gene, AMY1, which codes for an enzyme called amylase, and certain bacteria in the gut and mouth. The amylase enzyme acts in the saliva to break down starches. When people have many copies of the AMY1 gene, they tended to have a certain gut and mouth bacteria profile. https://lnkd.in/d_ETR8cT

Identifying factors responsible for the virulence of disease-causing bacteria is often complicated by the existence of multiple genes that perform similar functions. Experimental methods to disrupt a single gene may not produce detectable effects, hindering further analyses. Learn about how a method, developed by NICHD’s Machner Lab to simultaneously disrupt multiple genes identified gene combinations critical for bacterial virulence. https://go.nih.gov/zieZM7J. National Institutes of Health (NIH): Intramural Research Program (IRP) #NICHDimpact

Did you know? Our study is recruiting patients w/ #ATP1A3 gene variants: https://buff.ly/3EN20Wz We aim to better identify characteristics associated w/ #RDP, #AHC & #CAPOS. We also aim to explore whether variants in the ATP1A3 gene are linked w/ dystonias & #ParkinsonsDisease.

"Targeted mutations in the GW2.1 gene modulate grain traits and induce yield loss in barley" with Agrisera antibodies to HSP90-1. To article: https://lnkd.in/d_r2myDg #Cropyield #Genomeediting #Hordeumvulgare

One dose CRISPR therapy cuts cholesterol by up to 55% The first human trial of base editing delivered strong results along with some safety concerns. "VERVE-101, is designed to deactivate a gene in the liver that controls the production of PCSK9, a protein that regulates the amount of LDL in the blood. VERVE-101 permanently deactivates the PCSK9 gene in the liver by using CRISPR to change just one letter in its DNA. This technique is called “base editing,” and Verve’s trial is the first to test it in humans." https://lnkd.in/ePvEAv6M

How to find if genes on the same chromosome or not? Linked genes are genes that are likely to be inherited together because they are physically close to one another on the same chromosome. During meiosis, chromosomes are recombined, resulting in gene swaps between homologous chromosomes. Youtube video: https://lnkd.in/dXm5RSk2 #nikolaysgeneticslessons