Kuros Biosciences’ Post

Did you know stem cells live in different tissues and organs throughout your body—including your liver, muscles, and skin? Learn about stem cells and their unique abilities in our new Biomedical Beat blog post—link in comments. #StemCells #BasicResearch

🧫 Trivia Question: What is the primary challenge in engineering functional tissue constructs for regenerative medicine? A. Insufficient integration with the host tissue B. Difficulty in recreating the complex vascular networks C. Limited availability of suitable stem cell sources D. High susceptibility to immune rejection #RegenerativeMedicine #TissueEngineering #MedTechTrivia #BiomedicalResearch Sciqst, Precise References in Medicine. www.sciqst.com

#TuesdayReads Ruxandra Dafinca et al.'s paper, uncovering how mitochondrial dysfunction and axonal transport deficiencies drive motor neuron degeneration in Amyotrophic Lateral Sclerosis (ALS), has made the cover of Brain Communications! The image represents a human motor neuron differentiated from the induced pluripotent stem cells of a patient with #ALS. The neuron was transduced with a virus that expresses green fluorescent protein and we used this system to show that expressing a dynactin-1-GFP rescues axonal transport defects associated with motor neuron degeneration in ALS. To take the image, the group used the confocal microscope from Micron Bioimaging facility Zeiss LSM. 👉 https://lnkd.in/gAVmZPDQ

IT COULD BE THE PATCH! Bringing some science to you. What patch? The LifeWave X39 patch. It employs phototherapy to stimulate the production of GHK-Cu, a peptide known to activate stem cells, thereby supporting the body's natural healing processes. Want to feel better? The patch could be what you've been waiting for. #x39patch #lifewave #thisisit #phototherapy #TechTuesday #LifeWaveX39 #StemCellActivation

Developing an extracellular vesicles engineering platform to enhance stroke treatment outcomes: in this article, Xiaojing(Jenny) Shi at McGovern Institute for Brain Research, tang yaohui at Shanghai Jiao Tong University and collaborators described the development of a dopamine-based surface functionalisation platform that enables the simultaneous conjugation of targeting peptides and multi-modal imaging probes to extracellular vesicles. Using this approach, they modified M2 microglia-derived EVs (M2-EVs) with the neuronal targeting peptide RVG29 and imaging tracers, facilitating targeted delivery to the brains of stroke-affected mice. This modification also enabled dynamic visualisation of the targeting process at both whole-body and cellular levels https://lnkd.in/ezG8zphd They found that intra-arterial injection achieved the highest efficiency in delivering engineered EVs to the stroke-affected brain, significantly reducing neuronal apoptosis and improving therapeutic outcomes. Their platform offers a straightforward and versatile tool for multifunctional EV engineering, advancing both the evaluation and therapeutic potential of EV-based treatments with promising prospects for clinical applications. An article co-authored by Lu Zhang, Shengju Wu, Chunfu Zhang, Muyassar Mamtilahun, Yongfang Li, Zhijun Zhang, Changjing Zuo, Fengzhen Cui, Wanlu Li and Guo-Yuan Yang #extracellularvesicles #exosomes #stroke #targeteddelivery #bioengineering #Vesiculab

🌟 Excited to share the Editor’s Choice Paper, Volume 10 Issue 4: Electrical Stimulation in Cartilage Tissue Engineering. 🥼 This paper is authored by Raminta Vaiciuleviciute, Ilona Uzieliene, Paulius Bernotas, Vitalij Novickij, Aidas Alaburda and Eiva Bernotiene. 💡 This review focuses on the application of ES for chondrocyte and mesenchymal stem cell chondrogenesis for cartilage tissue regeneration. Welcome to view this paper here👉 : https://lnkd.in/eJAWssPQ. #cartilage #osteoarthritis #chondrogenesis #electrical_stimulation #mesenchymal_stem_cells

💡Fascinating Discovery: Memories Beyond the Brain! 🔷Recent research has unveiled a groundbreaking revelation – kidney and nerve cells might have the ability to store memories, much like our brain cells! 🧠💡 🔷This intriguing finding opens up new doors to understanding how cellular memory functions across different organs in the human body. Could this be a game-changer for regenerative medicine, organ transplantation, or even personalized treatments? 🧬 Here's why this discovery matters: 1️⃣ Organ Communication Redefined: The possibility that non-neural cells can retain "memories" could explain how organs adapt to repeated stress or environmental stimuli. 2️⃣ Advancing Medical Therapies: Understanding this mechanism could lead to breakthroughs in chronic disease management, particularly for kidney and nerve-related conditions. 3️⃣ Interdisciplinary Impact: From neuroscience to biochemistry, this finding bridges diverse fields and invites collaborative innovation. #CellularMemory #BiomedicalResearch #InnovationInScience #RegenerativeMedicine #ScientificBreakthroughs

Measuring the redox state of cells can be done with the autofluorescence of NAD(P)H. Using the ratio of 405nm emission to 488nm emission can be done but with problematic background. Lifetime imaging solves this but at the cost and complexity associated with FLIM. "Optical redox imaging to screen synthetic hydrogels for stem cell-derived cardiomyocyte differentiation and maturation" https://lnkd.in/g4Wv_H5S

How Are Regenerative Medicine & Hyperbaric Oxygen Therapy Revolutionizing the Future of Healing? Regenerative medicine is an innovative field focused on restoring or replacing damaged tissues and organs through various advanced techniques, including stem cell therapy, tissue engineering, and molecular biology. These methods aim to significantly alter treatment options for a variety of medical conditions. Hyperbaric oxygen therapy (HBOT) is one such promising approach, which has drawn attention for its potential to aid in tissue healing, slow the aging process, and help mitigate the effects of radiation-induced injuries. Read full scientific article: https://lnkd.in/eZSvaiBi Schedule Consultation with AHA International Sales Expert for more information: email: ask@aha-hyperbarics.com tel: +43 664 398 98 14 #StemCellTherapy #HBOT #RegenerativeMedicine #HealingInnovation

Cerebral organoids reciprocally connected with axons Previous studies have tried to create brain circuits under laboratory conditions, which have been advancing the field. Researchers have recently found a way to create more physiological connections between lab-grown “neural organoids,” an experimental model tissue in which human stem cells are grown into three-dimensional developmental brain-mimicking structures. The team did this by linking the organoids via axonal bundles, which is similar to how regions are connected in the living human brain. The cerebral organoids that were connected with axonal bundles showed more complex activity than single organoids or those connected using previous techniques. In addition, when the research team stimulated the axonal bundles using a technique known as optogenetics, the organoid activity was altered accordingly and the organoids were affected by these changes for some time, in a process known as plasticity. #ScienceMIssion #ScienceNewsHighlights https://lnkd.in/gvYPt3_b