Labiotech.eu’s Post

Promotion: LAB-A-PORTER x OriGene. Use Promo Codes To Redeem Your Offer Today! To support your research needs on recombinant proteins, OriGene and LAB-A-PORTER are thrilled to announce a special promotion for selected recombinant proteins! From now until 31 March 2024, for purchase of MVPro recombinant proteins from OriGene, you can receive 20% off. Limited offer. Grab the chance to stock up on some recombinant proteins! Use promo code: MVPRO20 to redeem your offer today! T&C applies. All products listed on this site and sold through LAB-A-PORTER Limited are for research use only (RUO). Not for human use. Not for therapeutic or diagnostic use. Learn more: https://lnkd.in/gbaewUMy

We are excited to be a part of 23rd Annual PepTalk Event from 16-19 January, 2024 to be held at San Diego, CA. Meet us at booth 503 to learn more about our protein science portfolio. Whether you are focused on lead discovery, production of targets for high throughput screenings, or characterization of unique gene products or antibodies, our proprietary one-stop transient expression system will help optimize the expression and purification of your products. All purified biologic products can be characterized in our well-equipped analytical labs. We offer protein expression in multiple mammalian expression systems to meet every client’s need. ◉ Transient expression in CHO-S HEK-293, Expi CHO and Expi HEK ◉ Scale up of stable cell line and cell pool for purification ◉ Scale up of hybridoma for purification To know more visit https://lnkd.in/gaSJehVM or write to us at bd@aragen.com to set-up meeting with our experts.   #PepTalkEvent #ProteinScience #Biologics #SanDiego #PepTalk2024 #AragenBio #ProteinExpression #TransientExpression #CHOcells #HEK293 #LeadDiscovery #Hybridoma #AnalyticalLabs #BiotechEvent #MeetUsAtBooth503

For early January, here’s an interesting paper where the yield and activity of a difficult to express enzyme is improved, in CHO cells, using a systems biology and metabolic engineering approach. As the authors suggest, the type of workflow they describe could be used to improve production of other biotherapeutics. #biopharmaceuticals #biotherapeutics #biotechnology #systemsbiology #omics #celllinedevelopment https://lnkd.in/d_2Qp7ek

Preparation Techniques of Polypeptide - Genetic Engineering Recombination. The technology for producing #peptides by this method has become mature and has the advantages of not being limited by production raw materials and strong expression directionality. Gene recombination methods are often used to synthesize peptides with relatively long peptide chains, especially peptides composed of hundreds of amino acids. The #genetic recombination method can recombine the gene sequence that regulates polypeptide synthesis into the genetic material of microorganisms, etc., and translate and express the genetic material in the recipient organism. The yield and purity of the polypeptides obtained by this method are greatly improved, and it is currently one of the effective ways to obtain certain specific biologically active peptides in large quantities. However, it is limited to the synthesis of macromolecular peptides, and it is difficult to express short peptide chains. In addition, in recent years, consumers in Europe and the United States have generally opposed foods and health foods that have undergone #genetic #bioengineering. #peptide #enzyme #geneticengineering #biological #biology #biopharmaceuticals #pharmaceutical https://lnkd.in/gGmsgEUD

Understanding Recombinant Enzymes and Their Significance. Recombinant #enzymes are derived from genetically modified organisms (GMOs) and possess the ability to cut splice join, and replicate DNA molecules with remarkable precision. By harnessing these enzymes, scientists can manipulate genetic material with unprecedented accuracy, amplifying their impact on various industries. From medical research to agriculture, recombinant enzymes have paved the way for groundbreaking advancements. #enzymes #biology #biological #biosciences #geneticengineering #bioengineering #biopharmaceutical #biomedical https://lnkd.in/gcBNWznN

In conclusion, recombinant #enzymes have emerged as pivotal catalysts of change in the field of biomedicine. With their immense potential and diverse applications, these enzymes have paved the way for groundbreaking advancements in therapeutics, diagnostics, and beyond. Through ongoing research and refinement the impact of recombinant enzymes in biomedical advancements is only expected to grow, ultimately leading to the development of more effective and accessible treatments for various diseases and medical conditions. #enzyme #bioengineering #biotechnology #biotechnologies #geneticengineering #biology #protein #genetic #biomedicalengineering #biomedical #biopharma #biopharmaceutical https://lnkd.in/gcBNWznN

Recombinant protein expression system - yeast expression system. According to the type of host cell, gene expression systems can be divided into prokaryotic expression systems, yeast expression systems, mammalian expression systems, and insect expression systems. Yeast is a eukaryotic microorganism whose cells have the ability to express foreign proteins and can reach a very high cell density state. Expressing foreign proteins in yeast can undergo post-translational modifications, such as phosphorylation and glycosylation. Since yeast host cells combine the excellent properties of bacterial and higher-order organism host cell expression systems, they are a good choice when foreign proteins cannot be successfully expressed in E. coli. Yeast strains used for foreign protein expression include Saccharomyces cerevisiae, Schizosaccharomyces pombe, Pichia pastoris, and Kluyveromyces lactis. The recombinant #trypsin, recombinant #lysyl endopeptidase, #Kex2 protease, #enterokinase, etc produced by Gene-Biocon are expressed by yeast. #cell #biology #biological #Biotechnology #bioengineering #geneticengineering #expression https://lnkd.in/gcBNWznN

The Business Research Company presents updated insights on the Difficult-to-Express Proteins Market: Market Momentum: Growth from $4.11B in 2023 to $4.63B in 2024, with a notable CAGR of 12.6%. Key Drivers: Increased demand for protein therapeutics, biopharmaceutical advancements, and technological constraints drive growth. Future Projections: Expected to reach $7.09B by 2028, driven by novel expression systems, gene editing, and AI integration. Key Trends: Innovative protein folding technologies, synthetic biology expansion, and targeted protein modification are anticipated. #difficulttoexpressproteins #markettrends #biopharmaceuticals #researchinsights #tbrc View more: https://lnkd.in/gcbFr-kw

The enzymes that Gene-Biocon studies and produces. You can find Recombinant Trypsin, Recombinant Lysyl #Endopeptidase, #Carboxypeptidase, #Enterokinase, #Kex2 protease and #Penicillinase from Gene-Biocon plant. Those are genetic engineering enzymes produced by our scientists. We produce enzymes from microorganisms. There are various #microorganisms. Almost all enzymes present in plants and animals can be obtained from microorganisms, and the most suitable strains can be obtained through isolation and screening. Microorganisms have strong adaptability which can generate new and highly productive enzyme-produced bacterial strains through various means of genetic variation. #biology #biologicals #bioengineering #enzyme #biopharmaceutical https://lnkd.in/gcBNWznN

Read this case study to understand how Aragen’s expert team of scientists helped its client obtain more than 80 mg of a mammalian secretory protein, whose expression in its soluble precursor form is considered challenging in recombinant protein expression systems. Aragen’s team redesigned the workflow to create a cost-effective, scalable process to achieve successful expression of the untagged protein in E. coli expression system and facilitate its subsequent in vivo maturation. The team optimized expression parameters to enhance yield of the recombinant protein’s mature form. We further refined and optimized the initial trial protocol provided by the client to meet standard quality and quantity requirements for the final product. Subsequently, our team redesigned the purification protocol to attain standard specifications in a scalable format with reduced turnaround time. This case study highlights Aragen's expertise, instrumental in reshaping the client's strategy and achieving a critical milestone. To read the whole case study click here https://lnkd.in/gHcgKmMa or write to us at info@arage.com #invivo #invitro #drugdiscovery #drugdevelopment #casestudy #lifesciences #endtoendsolutions #protein