WuXi AppTec, Laboratory Testing Division’s Post

Antibody-drug conjugates (ADCs) lead the way in innovative biotherapeutics. However, understanding the complex landscape of their ADME (absorption, distribution, metabolism, and excretion) properties during discovery and development stages is challenging. 👉 Join us on March 20th from 11:15 to 11:45 AM EST for a free webinar with the @American Association of Pharmaceutical Scientists (AAPS)|@aapscomms. During the webinar, we will be sharing insights and strategies to accelerate ADC development. Topics include: ✅ Payload release mechanisms ✅ Identification of catabolites in various in vitro systems ✅ Detection of drug–antibody ratios (DAR) ✅ The implementation of an integrated bioanalysis platform catering to both small and large molecules Free registration at AAPS: https://hubs.li/Q02p5QQ40 #aaps #adc #drugdiscovery #drugdesign #bioanalytical #dmpk #adme

Recap of Biologics 2024:  We had a great time discussing and learning about new innovations and technologies in peptide therapeutics.  Some highlights: Vera D'Aloisio participated in the Panel Discussion: Sustainability In Tides Chemistry: An Integrated Approach Michael Pennington presented “Peptide Synthesis Strategies for Production of Commercial GLP-1 Agonists". -with Georgina Balcells, Mikael Moissant AmbioPharm has additional industry events in March where we will be speaking and available to showcase our peptide manufacturing and development services. 🗓 Upcoming March Conferences: DCAT Week | March 18-21 | NYC, NY USA TIDES Asia | March 19-21 | Kyoto, Japan https://lnkd.in/eH48ZARU #OGBiologics #Biologics24 #cgmp #peptides #cdmo #drugdevelopment #peptidesynthesis #peptidetherapeutics #biologicsuk #sustainability

𝐃𝐢𝐟𝐟𝐞𝐫𝐞𝐧𝐭𝐢𝐚𝐥𝐥𝐲 𝐞𝐱𝐩𝐫𝐞𝐬𝐬𝐞𝐝. 𝐃𝐢𝐬𝐞𝐚𝐬𝐞-𝐦𝐨𝐝𝐢𝐟𝐲𝐢𝐧𝐠. 𝐓𝐫𝐚𝐜𝐭𝐚𝐛𝐥𝐞 𝐟𝐨𝐫 𝐭𝐡𝐞𝐫𝐚𝐩𝐞𝐮𝐭𝐢𝐜 𝐦𝐨𝐝𝐮𝐥𝐚𝐭𝐢𝐨𝐧. Join our live #webinar on September 18 to learn how you can identify protein targets with these characteristics using mass spectrometry-based #proteomics and #AI-based target validation – for ADCs, #radioligands, cell engagers, protein degraders, and other innovative drug modalities. Register today!: https://lnkd.in/gUGxd22a Presented by Mo Jain, MD PhD Hosted by American Association of Pharmaceutical Scientists (AAPS) | @aapscomms #targetidentificaton #targetvalidation #proteintarget #targetdiscovery

Age-related Macular Degeneration (AMD) Researchers/Scientists Highlighting some of the capabilities and competencies of our Phenocell team in France. Identify new pharmaceutical active ingredients with our selection of innovative high-throughput bioassays using iPSC-derived retinal pigment epithelial (RPE) cells. Axol’s dry AMD model is based on the use of iPSC-derived RPE cells from multiple donors including cells differentiated from healthy donors, and cells from AMD patients with risk alleles. We have a range of high-throughput bioassays including: ·      growth factor secretion ·       outer retinal barrier resistance ·      phagocytosis ·      immunolabelling ·      oxidative stress ·      cell viability While every project is unique, we utilize established workflows to ensure projects are conducted efficiently with a kick-off meeting, open communication and full data sharing. Learn more: https://lnkd.in/ewHmX5_Y or get in contact with us at operations@axolbio.com #drugdiscovery #eyedisease #biotech #maculardegeneration

The #diagnostics of #MentalDisorders 🧠 need a fundamental renewal❗ The current session IN01 at #ECNP2024 in Milan 🇮🇹 focuses on a new diagnostic framework, based on the underlying biology, to help patients more effectively!  🏥🩺❤🩹 Martien Kas European College of Neuropsychopharmacology (ECNP)  EFPIA - European Federation of Pharmaceutical Industries and Associations  #PRISM2

The conference report about EUFEPS open forum on ICH M13A is now available! During the meeting the most relevant aspects of the ICH M13A draft have been discussed in order to contribute scientifically to the decision process of guideline finalisation. Major aspects have been the choice of study population (females and/or males), request for fasted and/or fed studies, consequences of differences in drug product content, handling of aberrant plasma profiles and additional requirements in case of pH-dependant solubility. We are happy that Ralph-Steven Wedemeyer, our expert on biopharmaceutics, contributed to the program, the conference as well as to the report as one of the co-authors. #Bioequivalence #EarlyPhase #Biopharmaceutics https://lnkd.in/eg8mJe_G

An optimal #protein target is one that is 1) mechanistically involved in disease pathogenesis, 2) uniquely or differentially expressed in diseased cells, and 3) tractable, with properties that allow it to be modulated by the drug. In this #webinar, hosted by American Association of Pharmaceutical Scientists (AAPS) | @aapscomms, we will discuss how mass spectrometry-based discovery #proteomics combined with #AI-based target validation can be used to comprehensively characterize the expanded breadth of potential protein targets to identify the best target for a given therapy. Register now to join us and speaker Mo Jain, MD PhD for the live discussion on September 18th: https://lnkd.in/gUGxd22a #targetdiscovery #targetidentification #targetvalidation

📰 A recent issue of International Pharmaceutical Industry (IPI) Journal featured Proveris Laboratories in an article titled ‘Emerging Trends in Nasal Spray Development: Tools for Future Success.’ The article reviews the benefits of pairing in vitro development testing with in vitro human-realistic deposition testing―enhancing nasal product development, reducing the risk and time to market. ⭐ Highlighted is the Proveris Nasal Cast, an accurate model of realistic complex geometries and barriers that are important to account for when targeting specific regions like the Olfactory region and the NALT region. 🔬 Proveris Laboratories pairs traditional testing with demographic specific human actuation parameters, and human realistic nasal cast testing, to elevate development. ⬇ Download the article: https://lnkd.in/dpm3cVZ 🤝 Contact us for expert assistance: https://lnkd.in/eu-MTGKq #ProverisLaboratories #LaboratoryTestServices #OINDP #Nasal #DrugDelivery #NasalCasts #HumanRealisticTesting

I am happy to share that my review article "New Halogen-Containing Drugs Approved by FDA in 2021: An Overview on Their Syntheses and Pharmaceutical Use" has been awarded the second place prize of MDPI Molecules 2022 Best Paper Award. The winners were chosen by a selection committee chaired by the Editor-in-Chief, Prof. Dr. Thomas J. Schmidt. Link to the paper: https://lnkd.in/d9VZsgAA Many thanks to the research group led by prof. Claudio Santi at the department of pharmaceutical sciences, University of Perugia, Italy. --Read, enjoy, cite-- #drugs #halogen #fluorine #chlorine #buildingblock #purification #covalent #inhibitors #smallispowerful #smallmolecules #molecules #chemicallibrary #aromatic #aliphatic #pharma #chemistry #drugdiscovery #science #hit #lead #structure #activity #drughunters #drugdevelopment #healthcare #blockbuster #sales #medicinalchemistry #chemicalspace #FDA #approved #discovery #synthesis #multistep #disease #treatment #viralinfections #cancer #cardiovasculardisease #multiplesclerosis #migraine #inflammatorydiseases #tivozanib #sotorasib #melphalanflufenamide #asciminib #infigratinib #umbralisib #piflufolastat #belzutifan #cabotegravir #maribavir #ponesimod #atogepant #avacopan #vericiguat #nirmatrelvir #universityofperugia #unipg

📍A new #webinar will be organised by IPS - Industrial pharmacy section of FIP on 16th July 2024, 3pm CET, with the topic: "Advancements in Inhalable Nano-Drug Delivery Systems for Targeted Lung Therapy''. Our speaker will be Jyothi Menon, PhD, Associate Professor - Biomedical, Pharmaceutical Sciences and Chemical Engineering. Read more details and *register* your attendance below 👇 https://lnkd.in/efwZZs3Q  After participating in this webinar, attendees will be able to : 1. Describe the advantages of pulmonary drug delivery 2. Outline the fundamental challenges to delivering inhalable therapies to the lungs 3. Identify key considerations while designing drug-loaded nanoparticles for pulmonary drug delivery applications International Pharmaceutical Federation (FIP) #fipdigitalevents #fip #pharmacy