Latigo Biotherapeutics, Inc.’s Post

#Researchers: MMP-13 is a key protein in the matrix metalloproteinase (MMP) family, however, the absence of sufficiently selective inhibitors has hindered studies into its function. Recently, the design of a selective MMP-13 inhibitor at Boehringer Ingelheim, and its free distribution through #opnMe, have resulted in exciting discoveries in osteoarthritis and aortic aneurysm.   Register for our seminar to hear the full story of this scientific journey and listen to a panel of experts as they highlight the mechanistic roles of MMP-13:   https://lnkd.in/eRXqNBWN

#Researchers: MMP-13 is a key protein in the matrix metalloproteinase (MMP) family, however, the absence of sufficiently selective inhibitors has hindered studies into its function. Recently, the design of a selective MMP-13 inhibitor at Boehringer Ingelheim, and its free distribution through #opnMe, have resulted in exciting discoveries in osteoarthritis and aortic aneurysm.   Register for our seminar to hear the full story of this scientific journey and listen to a panel of experts as they highlight the mechanistic roles of MMP-13: https://lnkd.in/ecXjuF2k #openscience #boehringer

Quantifying the concentration of BSA in various applications is essential from a safety and efficacy perspective. Our white paper about BSA quantification with ELISA focuses on Bethyl’s Bovine Albumin ELISA Kit (E11-113) which can quantify BSA in various sample types, including serum, milk, plasma, colostrum, and cell culture media. Download this white paper to learn about: - The Significance of BSA in Biomedical Research - Quantification of BSA with Sandwich ELISA - Resources & Tips for Reproducible BSA ELISA https://ow.ly/9YJb50Rmy9x #CellCulture #WhitePaper #ELISA #BSAQuantification #SandwichELISA #BiomarkerAnalysis #Biomarker

In this 2022 paper "In silico identification of a β2-adrenoceptor allosteric site that selectively augments canonical β2AR-Gs signaling and function", SILCS was used to identify a novel allosteric site on the β2-adrenoceptor. This allows for selective enhancement of β2AR-Gs signaling, offering potential for targeted therapeutic interventions with fewer side effects. This study shows the applicability of SILCS to membrane proteins, as protein flexibility is taken into account during the simulations." #compchem #SILCS #membraneproteins

According to Thomas J. Ettrich, MD, Hochschule Neu-Ulm, and coauthors, "NIFE is the first prospective trial demonstrating efficacy of [nanoliposomal irinotecan with fluorouracil and leucovorin] in the first-line therapy setting… and this regimen merits further validation in a larger phase III trial." Learn more: https://lnkd.in/g2QZfxHW

The lung Ciliary Beat Frequeuncy (CBF) analysis in vitro assay helps assess the effect of drugs and chemicals on the function of cilia in the small airway epithelium. It predicts mucociliary clearance, evaluates drug efficacy and safety, dosing and compound kinetics. We recently caught up with Dr. Megan Jo Webster, PhD, Head of Lung Platform, to find out more about the development of CBF and the capabilities of the software to assess the effect of drugs and chemicals on the function of the ciliated cells within the lung small airways. Learn more 👉 https://lnkd.in/e9CEZRUC #Newcells #Lung #InVitro

Quantifying the concentration of BSA in various applications is essential from a safety and efficacy perspective. Our new white paper about BSA quantification with ELISA focuses on Bethyl’s Bovine Albumin ELISA Kit (E11-113) which can quantify BSA in various sample types, including serum, milk, plasma, colostrum, and cell culture media. Download this white paper to learn about: - The Significance of BSA in Biomedical Research - Quantification of BSA with Sandwich ELISA - Resources & Tips for Reproducible BSA ELISA https://ow.ly/9YJb50Rmy9x #CellCulture #WhitePaper #ELISA #BSAQuantification #SandwichELISA #BiomarkerAnalysis #Biomarker

Monocyte-activation test (MAT) was added to the Ph. Eur. in 2010, providing an in-vitro alternative to the Rabbit Pyrogen Test (RPT) that is capable of detecting both endotoxin and non-endotoxin pyrogens (Eur. Ph. 2.6.30). Nevertheless, the RPT has remained the gold standard for pyrogen detenction, regardless the low sensitivity, the qualitative nature and the intense animal consumption. As consequence, the European Pharmacopoeia Commission has developed a pyrogenicity strategy document that aimed to move towards the exclusive use of in vitro tests for the control of pyrogenicity. This will lead to the complete removal of the in-vivo test (RPT) from the Ph. Eur., which is planned for July 2026 and several changes in the European Pharmacopoeia. The new version of Eur. Ph. 2.6.30 is due to be official by July 2024 in European Pharmacopoeia 11.5. 📧 To have more information you can contact us at: consultancyitaly@bpt.eurofinseu.com

The CD63 Basophil Panel-1 assay activates basophils to quantify immune engagement and measure CD63, a marker of basophil activation. Read our scientific poster to see how our sensitive flow cytometry method assesses drug effects on basophils, helping optimize dosing and demonstrate efficacy in multi-centric clinical trials: https://lnkd.in/gfJZqn9z #FlowCytometry #Basophils

Attending #MSACL2024 in Monterey?! Make sure you stop by booth #21 to learn how SCIEX's LC-MS/MS solutions can help you advance your work in #clinical research and diagnostics. And make sure to check out our posters in the Exhibit Hall (Serra) showcasing the latest clinical applications. #ClinicalAnalysis #InnovationMatters #EducationMatters SCIEX is presenting 3 posters on the following topics: -High-resolution mass spectrometry peptide quantitation for biomarker verification with limited method development (Poster #10b) -Quantitative and qualitative analysis of steroids with simplified sample preparation (Poster #4a) -Development of highly sensitive analytical techniques for the detection of galactosylsphingosine (GalSPH) and glucosylsphingosine (GluSPH) in cerebral spinal fluid (Poster #4b) Advance your clinical knowledge with our posters from MSACL 2024! https://bit.ly/4a4Axx0