Legend Biotech’s Post

Quick read and insightful look into how CAR-T is transforming the treatment of cancer.

Investigation of long term effects for any type of new treatments, especially involving #ATMPs is critical, #cellandgenetherapies are complex, relatively new and come with many challenges on the way, #FDA actions are totally understandable, it’s necessary to keep learning and to make any type of therapies even safer and more standardised for future generations

Happy Monday all! Check out this open access Frontiers in Immunotherapy article by Maria Letizia Giardino Torchia and Gordon Moody where they develop a tool to characterize adoptive cell immunotherapies. "The acronym DIAL stands for Distribution, Infiltration, Accumulation, and Longevity, compartmentalizing the systemic attributes of gene-modified cellular therapy and providing a platform for optimization with the ultimate goal of improving therapeutic efficacy. This review will discuss both existent and emerging examples of DIAL characterization in mouse models, as well as opportunities for future development and optimization." #drugdiscovery #drugdevelopment #immunotherapy #cancerresearch #immunooncology #scientificresearch #cartcelltherapy #sciencecommunication

Dr. Divya S. Mishra, a Board-Certified Oncologist, explores the exciting potential of #Redoxhomeostasis in #cancertreatment. New research from Tata Medical Centre is investigating #nutraceutical combinations to improve outcomes and manage treatment toxicity. This focus on cellular foundation holds immense promise for cancer patients worldwide. Insightful Article: https://lnkd.in/gJfguXFT #clinicaltrials #clinicalresearch #cancerresearch

Exciting news for the autoimmune space! Cell therapies are showing great potential in the race for a cure, with many players in the game. Looking forward to following the progress of these cell therapies and the impact that they will have on patients world wide. Linked is a great article that describes the current state: https://lnkd.in/eU-8xSfu

#AI is changing the game in #medicine! From crafting new drugs for idiopathic pulmonary fibrosis to predicting treatment responses in head and neck cancer patients, #AI is accelerating #treatment #discovery and improving #patientcare and outcomes. How do you think AI will continue to shape the #future of healthcare? Share your thoughts! #AIinMedicine #TreatmentAdvancements #nvidia #insilicomedicine #Lunit https://lnkd.in/gjMDzQxe

Engineering a Programmed Death-Ligand 1-Targeting Monobody Via Directed Evolution for SynNotch-Gated Cell Therapy https://lnkd.in/g2TyeCQX

Are cell therapies ready for prime time? This article explores ways to make cell therapies more widely used. Thanks Neil Sheppard D.Phil & Jeanne Loring for your insights!

Check out AACR 2023 poster #2548 to see a great example of using our BioIVT PBMCs in combination with 3D cell culture to aid in anti-cancer therapy development, with the poster showing that: 1. Direct activation of T cells produced a significant increase in cytotoxicity compared to general activation using no target cells, whereas a diminishing effect was evident if the target cells were co-cultured with fibroblasts during the activation process. 2. The 3D cell model was proven to maintain superior cell health throughout long kinetic runs compared to 2D cell models. 3. Cytotoxicity may be quantified using propidium iodide or brightfield (label-free) methods

Unlike drugs that treat symptoms or slow disease progression, cell therapies could reverse the course of disease. What is keeping these treatments from our hospitals? Read more about cell therapy development and manufacture, regulatory barriers, transplant rejection and the likely candidates you'll see patients get access to in my summary of a recent expert panel discussion below. #CellTherapy #StemCellResearch #StemCellTherapy