Leibniz Institute for Prevention Research and Epidemiology - BIPS’ Post

🚀 Exciting Research in Perinatal Asphyxia: Salivary Gland Lactate Dehydrogenase as a Novel Diagnostic Test! 🚀 Perinatal asphyxia is a critical condition affecting newborns, especially in developing countries. Early and accurate diagnosis is crucial for improving neurodevelopmental outcomes and providing timely interventions. Recent research highlights a promising advancement in this area: Salivary Gland Lactate Dehydrogenase (LDH) is emerging as a novel diagnostic tool. This innovative test could revolutionize how we anticipate neurodevelopmental outcomes in infants who experience perinatal asphyxia. 🔬 Why Salivary Gland LDH? 1. Non-invasive: Utilizing saliva makes the testing process less invasive and more accessible. 2. Early Detection: This test could facilitate earlier diagnosis and intervention, improving the chances of better developmental outcomes. Cost-Effective: In resource-limited settings, this method provides a cost-effective alternative to current diagnostic techniques. In developing countries, where resources are often limited, this advancement could make a significant impact by enabling more timely and accurate assessments of newborns at risk. As we continue to explore and validate these findings, the potential benefits for neonatology and global health are immense. Let's stay informed and engaged in the strides being made in this critical field. #HealthcareInnovation #Neonatology #PerinatalAsphyxia #MedicalResearch #GlobalHealth #DiagnosticAdvancements

Antenatal Neuroprotective Strategies: Insights and Applications (Part 1) This week in our journal club, we had the privilege of discussing with Dr. Julia Buchmayer & Prof. Katrin Klebermaß-Schrehof a pivotal study on antenatal (and postnatal) neuroprotective strategies for preterm infants, led by an esteemed group of clinicians and researchers (eleanor molloy et al., 2023). Antenatal corticosteroids, such as dexamethasone, are administered to pregnant women at risk of preterm delivery to accelerate fetal organ maturity. These steroids enhance lung maturation by promoting surfactant production, stabilize the brain's blood vessels to reduce the risk of hemorrhage, and mitigate inflammation-related organ damage. Their use has been linked to significant benefits including reduced neonatal mortality and respiratory distress, though they must be used carefully due to potential risks. Magnesium sulfate, primarily used for its neuroprotective properties, helps regulate neuronal calcium flow and reduce inflammation, potentially preventing brain damage from oxygen deprivation and promoting vasodilation to improve cerebral blood flow. While it significantly lowers the risk of cerebral palsy, its effectiveness in reducing other deficits remains under discussion, and it does not notably decrease neonatal mortality. As we advance our understanding and refine these interventions, our goal remains to not only boost survival rates but also enhance the quality of life for these vulnerable infants. We are, therefore, committed to continuous research and cautious optimism in our pursuit of effective neonatal care strategies. #Neonatology #Neuroprotection #Preterm #Brain #outcomes #Neurodevelopment

https://lnkd.in/g59Ku3Hq                                   Article title: Can Exposure to Volatile Anesthetics be a Tipping Point for AD Susceptible Populations?   Author(s): Ingrid R Niesman   Journal: Annals of Alzheimer's and Dementia Care   Journal ISSN: 2692-448X Abstract: The relationship between surgery induced Postoperative Cognitive Dysfunction (POCD) and the development of Alzheimer’s disease (AD) later has been a debatable question. Volatile anesthetics represent a potential environmental factor that can change the CNS both acutely and long-term. By interacting with membrane cholesterol to alter signaling in neurons or alter the normally quiescent microglial phenotype, volatile anesthetics are implicated in the development of POCD. The tipping point for triggering AD cyclic pathology may rest with individual AD genetic risk factors combined with the known molecular consequences of anesthetic exposure. This review covers genome wide association studies (GWAS) identified AD risk factors, actions of volatile anesthetics in the development of AD phenotypes and presents some newly discovered pre or post-anesthetic POCD attenuating therapies. #Isoflurane #GWAS #Neuroinflammation #Berberine #Minocycline #Deferoxamine #POCD #AlzheimersBiomarkers #AlzheimersDisease #AlzheimersDiseaseTreatment #AlzheimersDiseaseAmyloid #OnsetAlzheimers #AlzheimersTherapy #AlzheimersNeuroinflammation #AlzheimersDiabetes #FamilialAlzheimers #MicrogliaAlzheimers #DietAlzheimers #MemantineAlzheimers #AlzheimersDementia #AlzheimersDiseaseTau #AlzheimersDiseaseDiagnosis #AlternativeTreatmentsForAlzheimers #AlzheimersDiseaseRisk #ModelAlzheimersDisease #AlzheimersDiseasePathology #AlzheimersDiseaseDiabetes #AlzheimersDiseasePrevention #StressAlzheimersDisease #AlzheimersSigns #FrontotemporalDementia #VascularDementia #DementiaTherapy #LewyBodyDementia #DementiaCognitive #DementiaMusic #DementiaOccupational #DementiaParkinson #PhysicalDementia #DementiaTreatmentAndCare #DementiaDiagnosis #PrevalenceDementia #DementiaRiskAndPrevention #DementiaSymptoms #DementiaDepression #AdvancedDementia #SemanticDementia #RiskFactors #Age #FamilyHistory #Genetics #Heredity #GenesLinkedToAlzheimers #BrainHealth #HighBloodPressure #HighCholesterol #DamageToBrainCells #Hippocampus #CardiovascularRiskFactors #CoreMentalFunctions #Memory #CommunicationAndLanguage #AbilityToFocus #ReasoningAndJudgment #VisualPerception #DementiaCare #NonDrugTherapies #DementiaCaregiver #DementiaCaregiverBurden #DementiaCareMapping #DementiaCareNursing #DementiaCaregiverEducation #DementiaCareManagement #DementiaCaregiverIntervention #DementiaCaregiverDepression #EarlyOnsetDementiaCaregiver

Breaking ground in paediatric rare disease research! Wesley Research Institute is home to a groundbreaking trial using triheptanoin, a dietary fat, to treat Ataxia-Telangiectasia (A-T), a rare degenerative neurological disorder. This trial has shown promising results, with observed improvements in neurology scales and cellular biomarkers indicating the treatment’s effectiveness. A-T combines progressive cerebral palsy-like symptoms, immune function problems similar to cystic fibrosis, and an increased risk of cancer. Currently, there is no cure for A-T, but the collaborative efforts at the Wesley Research Institute are providing new hope for affected families through innovative treatment options. Professor David Coman, a renowned paediatrician specialising in metabolic medicine and genetics, has dedicated his career to caring for children with rare degenerative disorders. As a key figure at Queensland Children’s Hospital and the Wesley Research Institute, Professor Coman’s work has considerably advanced the understanding and treatment of rare diseases. Read more about this innovative clinical trial https://lnkd.in/gmAbVPtU #raredisease #clinicaltrials #research #rarediseaseresearch #showyourrare  

📃Scientific paper: Pathophysiology of primary hypertension in children and adolescents Abstract: The progress in research on the physiology of the cardiovascular system made in the last 100 years allowed for the development of the pathogenesis not only of secondary forms of hypertension but also of primary hypertension. The main determinants of blood pressure are described by the relationship between stroke volume, heart rate, peripheral resistance, and arterial stiffness. The theories developed by Guyton and Folkow describe the importance of the volume factor and total peripheral resistance. However, none of them fully presents the pathogenesis of essential hypertension. The multifactorial model of primary hypertension pathogenesis developed by Irving Page in the 1940s, called Page's mosaic, covers most of the pathophysiological phenomena observed in essential hypertension. The most important pathophysiological phenomena included in Page's mosaic form a network of interconnected “nodes”. New discoveries both from experimental and clinical studies made in recent decades have allowed the original Page mosaic to be modified and the addition of new pathophysiological nodes. Most of the clinical studies confirming the validity of the multifactorial pathogenesis of primary hypertension concern adults. However, hypertension develops in childhood and is even perinatally programmed. Therefore, the next nodes in Page’s mosaic should be age and perinatal factors. This article presents data from pediatric clinical trials describing the most important pathophysiological ... Continued on ES/IODE ➡️ https://etcse.fr/bfHdW ------- If you find this interesting, feel free to follow, comment and share. We need your help to enhance our visibility, so that our platform continues to serve you.

Standardized (but not individualized) exercise protocols are controversial in chronic fatigue disorders. If one has dysfunctional mitochondria (the cell’s power plant) it can be overwhelmed and one has post-exertional malaise (PEM). This loss of recovery capacity is possibly best pragmatically measured with nocturnal HRV as we do with athletes. Tracking nocturnal HRV will make the invisible recovery capacity problem visible. “Night-time (HRV) HF power at baseline was the most effective predictor that explained 27% of the variance in VO2max improvement with the training program used.” Kajawski 2021 #autonomicrehabilitation (Gharbo 2020) #chronicfatigue #physiatry

☑️ *READ ABSTRACT BELOW:* Keywords: CHD; Fetal echocardiography; maternal–infant bonding; prenatal diagnosis. Background: Infants with prenatally diagnosed Congenital Heart Disease are at high risk for adverse outcomes owing to multiple physiologic and psychosocial factors. Lack of immediate physical postnatal contact because of rapid initiation of medical therapy impairs maternal-infant bonding. On the basis of expected physiology, maternal-infant bonding may be safe for select cardiac diagnoses. Methods: This is a single-centre study to assess safety of maternal-infant bonding in prenatal CHD. Results: In total, 157 fetuses with prenatally diagnosed CHD were reviewed. On the basis of cardiac diagnosis, 91 fetuses (58%) were prenatally approved for bonding and successfully bonded, 38 fetuses (24%) were prenatally approved but deemed not suitable for bonding at delivery, and 28 (18%) were not prenatally approved to bond. There were no complications attributable to bonding. Those who successfully bonded were larger in weight (3.26 versus 2.6 kg, p<0.001) and at later gestation (39 versus 38 weeks, p<0.001). Those unsuccessful at bonding were more likely to have been delivered via Caesarean section (74 versus 49%, p=0.011) and have additional non-cardiac diagnoses (53 versus 29%, p=0.014). There was no significant difference regarding the need for cardiac intervention before hospital discharge. Infants who bonded had shorter hospital (7 versus 26 days, p=0.02) and ICU lengths of stay (5 versus 23 days, p=0.002) and higher survival (98 versus 76%, p<0.001). Conclusion: Fetal echocardiography combined with a structured bonding programme can permit mothers and infants with select types of CHD to successfully bond before ICU admission and intervention. Barker PCA, Cardiol Young. 2018 Nov;28(11):1306-1315. doi: 10.1017/S104795111800121X. Epub 2018 Aug 6. PMID: 30079851; PMCID: PMC6197928. #Gesundheit #Bildung #Fuehrung #Coaching #Mindset #Motivation #Gehirn #Neuroscience #Psychologie #Persoenlichkeitsentwicklung #Kindheit #KeyNoteSpeaker #Humangenetik #Biochemie #Neuroleadership #Ernaehrung #Transformation #Stress #Demografie #Gender #Age #interkulturelleKompetenz #Epigenetik #Veraenderung #EmotionaleIntelligenz #Change #Gesellschaft #Organisationsentwicklung #Philosophie #Beratung # Quantum

Background: Congenital hypothyroidism (CH) is one of the most prevalent endocrine disorders in children. According to the literature, there is a high prevalence of other anomalies and syndromes in infants diagnosed with CH. Objectives: This study finds the prevalence of concurrent anomalies and the prevalence of each one. Methods: This was a systematic review study based on the preferred reporting items for systematic reviews and meta-analysis (PRISMA). The research question was the comparison of children with and without CH in terms of having extra-thyroidal congenital anomalies. A systematic literature search through PubMed, Science Direct, Scopus, and the Web of Science databases was done using the following key words: Congenital hypothyroidism, birth defects, congenital anomalies. Results: From the 655 initially retrieved articles, 24 articles remained, and 4 additional references were found by reviewing the references of the final articles. Finally, 28 articles were selected. The prevalence of extra-thyroidal anomalies ranged from 5% to 50% in girls and from 4% to 80% in boys. Meanwhile, 20% of the permanent CH patients and 13% of the patients with transient CH had extra-thyroidal congenital malformations. Cardiac anomalies were more prevalent in girls (female to male ratio=1.6 [0.7 to 5.5]), and urogenital anomalies were more reported in boys. Most of the studies did not report the association between non-thyroidal anomalies and thyroid stimulating hormone, gender, etiology of CH, and transient and permanent CH. Conclusions: Congenital anomalies are more common in CH patients compared with the general population, even in the absence of congenital syndromes or chromosomal abnormalities. The most common anomalies are cardiac, craniofacial, urogenital, and nervous system. #CongenitalHypothyroidism #BirthDefects, #CongenitalAnomalies

📢 Our research group is at the European Endometriosis Congress #EEC2024 in Bucharest, Romania this week! We will be presenting 2 oral communications and 5 posters: ✅ Zélia Breton will have 3 presentations: ➡️ 1 oral communication on diagnostic delay of #endometriosis in the ComPaRe-Endométriose cohort ("Best selected oral communications" session, 2pm today in the Forum room) ➡️ 1 poster on #anxiety and #depression among women with endometriosis in the ComPaRe-Endométriose cohort (Poster P009) ➡️ And she will present a poster of her work on a pilot study of the Lyv digital programme to improve endometriosis patients' quality of life (Poster P008) ✅ Dr. Nadjib M. Mokraoui will present a poster about his work on comorbidities profiles among women with endometriosis in the ComPaRe-Endométriose cohort (Poster P108) ✅ Dr. Hélène Amazouz will present 2 posters: ➡️ An analysis of treatment patterns among women with endometriosis in the ComPaRe-Endométriose cohort (Poster P002) ➡️ A study of early life exposures in relation to endometriosis risk in the Nutrinet-santé cohort (Poster P001) ✅ Hélèna Schoefs will present a poster on complementary and alternative medicine among women with endometriosis in the ComPaRe-Endométriose cohort (Poster P056) ✅ And I will be speaking about how to counsel patients with regards to the risk of malignant transformation of #endometriosis ("Lightning Talks: Quickfire answers to burning questions" session, 2:35pm tomorrow in the Forum room) Please come and check out our work, we will be happy to chat with you about our interesting results! 📢 Also, please DO NOT MISS Dr. Jean Rosenbaum's poster that explains the French National Research Program on #Endometriosis and #Infertility (#PEPR Women's health, couples' health) that we are very lucky to have in France, and which will create many opportunities for collaboration and recruitment of early-career researchers worldwide! (Poster P054) European Endometriosis League World Endometriosis Research Foundation World Endometriosis Society endometriosis.org CESP - Centre de recherche en Epidémiologie et Santé des Populations Université Paris-Saclay Graduate School Santé Publique Paris-Saclay ComPaRe, la Communauté de Patients pour la Recherche

Thankful for the chance to collaborate on this paper recently published in the Lancet on #family #financialtoxicity of #pediatric #cancer in the #Philippines #SoutheastAsia led by Dr. Rod Carlo Columbres, together with Dr. Edward Christopher "Chris" Dee, MD, Dr. Erin Feliciano, MD, MBA, Dr. Michelle Ann Eala, MD, Fumiko Ladd Chino! . Cancer is a leading cause of death among children in the Philippines, a low-middle-income country of over 110 million people. In this Comment, we describe how financial toxicity affects families of pediatric patients with cancer in the Philippines. We explore direct costs of care, indirect costs such as transportation and lodging, and psychosocial sequelae, in the Filipino medical system and sociocultural contexts. We present examples of successful interventions in the Philippines and in similarly resourced settings, with the goal of galvanizing further research, clinical interventions, and policy-level changes, aimed at mitigating family financial toxicity for pediatric patients with cancer in the Philippines and globally. . Link to full paper: https://lnkd.in/g5VDW3AC . University of St. La Salle