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A new paper makes recommendations for dose selection in developmental and reproductive toxicity studies to avoid unnecessary animal suffering, reduce animal use and maintain the highest standards of human health protection: https://lnkd.in/eRzHWJAR Dr Fiona Sewell, NC3Rs Head of Toxicology and co-author of the paper said: "DART studies in animals are uniquely vulnerable to high dose-induced toxicity, which can yield findings irrelevant to human exposures and cause unnecessary animal suffering. This paper provides researchers with guidance on a science-driven approach to inform dose selection in these studies, to reduce and refine animal use and ensure meaningful, human-relevant data is generated.” 

Check out our latest article on a mechanism-based assessment of endocrine disrupting properties of #PFOS, based on AOPs and NAMs! 🎉 This project was A LOT of work and we identified several aspects that are important for the development of Next Generation Risk Assessment (#NGRA) of endocrine disruptors (EDs). In this paper, we compare a standard ED assessment against a mechanism-based assessment that did not utilize any in vivo data. Both assessments investigate thyroid disruption and developmental neurotoxicity caused by PFOS exposure. We utilize a thyroid-relevant Adverse Outcome Pathway (AOP) network to integrate data from New Approach Methodologies (NAMs) and to postulate a Mode-of-Action. Open access article available here: https://lnkd.in/dtxVsQK4 Thank you to all co-authors for your contributions to this great work: Marek Pípal, Jana Weiss, and Anna Beronius. #newapproachmethods #adverseoutcomepathways #karolinskainstitutet #chemicals #PFAS

Accelerate your project with fast turnaround In Vivo PK Screening with Admescope a Symeres company! Time is of the essence in drug discovery. Our fast-turnaround In Vivo PK Screening Service delivers critical pharmacokinetic data promptly, aiding swift decision-making. When in need of a more tailored approach, gain comprehensive insights through full PK profiles, analyzing parent compounds and metabolites, along with urine and feces excretion data from our state-of-the-art labs.   🚀 Beyond Traditional Molecules: We're not limited to small molecules! Our expertise covers peptides, mAbs, ADCs, oligonucleotides, and radiolabeled compounds can also be used.   🌍 Ethical Excellence: Rest assured, our experiments take place in an AAALAC accredited animal unit, highlighting our commitment to ethical research and its impact on human and animal health.   Contact our team today to discuss how we can support you! https://lnkd.in/dTaBD6aG #Admescope #Symeres #invivodmpk #drugdevelopment #drugdiscovery #admetox #pharmacokinetics

Evaluation of rat and rabbit embryofetal development studies with pharmaceuticals: the added value of a second species Puck Roos et al. Crit Rev Toxicol. 2024 Oct. https://lnkd.in/egBm27GE The toxicological studies of new drugs require 2 species to investigate the effects during the development of the foetus. In a significant proportion of the cases, the 2nd species in not needed. And in some rare case, the toxic effects can be seen only in this second species. Understanding species-specues mechanisms of action or effects of matériel toxicity is of most importance to study toxicity and prevent the toxic effectsnin humans. Including and mostly for all scientists who cannot use animals! Great review. #toxicity #NGRA #nonanimalstudies

Although we do not recommend eating #stickers, young kids have a mind of their own. 👶   One minute they’re sticking them on coloring books. You blink and suddenly their arms are covered in a sleeve of dinosaur stickers. 🦖   This is why it’s critical to choose #labels that have gone through extensive toxicology tests. We call them: #Child-Safe stickers. 🛡️   Want to learn more? Schedule time with one of our experts: https://lnkd.in/eNB7QSg7

New paper alert! Our group recently published a peer-reviewed paper titled "A review of the mesotheliogenic potency of cleavage fragments found in talc" in the journal Toxicology and Industrial Health. In the paper, we reviewed the current state of the science regarding the factors influencing mesotheliogenic potency of cleavage fragments, with emphasis on those that may co-occur in talc deposits, including dimensional and structural characteristics, animal toxicology, and the most well-studied cohort exposed to talc-associated cleavage fragments. Based on our review, multiple lines of scientific evidence demonstrate that inhaled cleavage fragments associated with talc do not pose a mesothelioma hazard. https://lnkd.in/gg6Gc86g For more information, reach out to lead author Eric Miller at eric.miller@benchmark-risk.com. The author team also includes Evan Beckett, MPH, CIH, Drew Cheatham, MS, Chris Comerford, Dr. Ryan Lewis, MS, PhD, CIH, Callan Krevanko, Neha Mandava, and Dr. Jennifer Pierce. #talc #riskassessment

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Eager to utilize NGS-based assay to replace traditional animal testing, but not GMP-ready? We're here to solve your problem. With our off-shelf #GMP readiness, you will start hit the ground running! #DigitalizingBiopharma #GenedataSelector #drugdevelopment #Bioinformatics #Biosafety

Check out a recent publication from my colleagues!

Looking to validate #NGS-based biosafety assays in a GMP environment? Genedata is your partner! Our blog provides practical guidance on in-house validation of your NGS assays, aligned with regulatory standards. Be part of the global shift from animal testing to NGS, a transition endorsed by regulatory guidelines. Check out our blog for more information: https://buff.ly/3zzjZQB #DigitalizingBiopharma #GenedataSelector #drugdevelopment #Bioinformatics #biosafety