Liam Pingree’s Post

Shown by us 10 years ago .. Upregulation of Chaperone proteins and consequent removal of beta amyloid in AD mice by 1072nm https://lnkd.in/exyc-cdq

Shown by us 10 years ago .. Upregulation of Chaperone proteins and consequent removal of beta amyloid in AD mice by 1072nm https://lnkd.in/exyc-cdq

THE BRAIN-DRAIN I Was encouraged to see the published studies over the past year, to attest to PBMs ability to increase lymphatics of the brain. We have seen many studies to show it’s advantages in neurological health and cognition. I have long promoted the real benefits of thorough lymph drainage and vagus work, and so too to promote the enormous benefits of ACCURATE PBM (it biphasic so accuracy is crucial). To be able to trust a therapy like PBM, that has so many benefits, to increase cleansing and detoxification of the brain is a game changer in wellness. Our specialised and unique protocols of care put PBM as a pivotal element of every facility we install. To us, PBM is as important to humans as Oxygen itself: You need both to trigger ATP (PBM being the right light). However, knowing when, how, why, in what order to use it and to incorporate it into a real care plan, is what makes all the difference and delivers accelerated results and outcomes for ultimate, reliable effects. #glymphatics #lymph #mentalhealth #PBM #integratedtherapy #wellness #ATP #alzheimers #dementia #braindrain #betaamyloid

#Alzheimer’s-Linked Neuronal Waste Expelled in #Coordinated Waves during Sleep:- •During #tranquil sleep the brain continues to demonstrate #bustling activity, and brain cells produce bursts of #electrical pulses that cumulate into #rhythmic waves—a sign of heightened brain cell function. •But the question remains why is the brain active when we are resting? •a study in mice,has now found that #brain waves help flush waste out of the brain during sleep. •The results indicated that individual #nerve cells coordinate to produce #rhythmic waves that propel fluid through #dense brain tissue, washing the tissue in the process. •The findings, the researchers suggested, could point to potential future #therapeutics or #preventive strategies against some #neurological #disorders. •These neurons are #miniature pumps, Synchronized neural activity powers #fluid flow and removal of #debris from the brain. •If we can build on this process, there is the possibility of delaying or even preventing #neurological diseases, including #Alzheimer’s and #Parkinson’s disease, in which excess waste—such as #metabolic waste and #junk proteins—accumulate in the brain and lead to #neurodegeneration. •The accumulation of metabolic waste is a leading cause of numerous #neurological disorders, yet we still have only limited knowledge of how the #brain performs #self-cleansing.” •Cleaning the #dense brain is no simple task. #Cerebrospinal fluid (#CSF) surrounding the brain enters and weaves through #intricate #cellular webs, collecting toxic waste as it travels. •Studying the brains of #sleeping mice, the researchers have now found that neurons drive cleaning efforts by firing electrical signals in a coordinated fashion to generate #rhythmic waves in the brain. •Firing of neurons in a highly #desynchronized fashion #maximizes the information complexity for diverse #cognitive tasks during wakefulness. •In contrast,during sleep, #neural networks synchronize individual action potentials to create #large-amplitude, #rhythmic and #self-perpetuating ionic waves in the interstitial fluid of the brain. “In essence, neurons are the most ideal cell type that coordinate the dynamics of #paravascular flow, brain #interstitial fluid and the blood–brain barrier to optimize #metabolic waste clearance." •#neurons coordinate their actions to generate large #amplitude, #rhythmic #ionic #oscillations in the #ISF during sleep (or #ketamine #anaesthesia). These high-energy ionic waves facilitate the perfusion of fresh CSF through the #parenchyma and the removal of metabolic waste products. In essence, neurons that fire together #shower’ #together.” •The research team silenced specific brain regions so that neurons in those regions didn’t create rhythmic waves. Without these waves, fresh cerebrospinal fluid could not flow through the silenced brain regions and trapped waste couldn’t leave the brain tissue. #neurons #csf #alzheimers #Neurodegenerativediseases

One Man Journal Club : Day 17 Adaptive Deep Brain Stimulation(DBS) This study tested a dual algorithm for adaptive DBS to account for sleep effects on biomarkers in Parkinson's patients. 4 Parkinson's patients had electrodes implanted in subcortical and cortical areas. One detector used cortical alpha and theta power to track sleep state with a single threshold. Another detector tracked Parkinsonian motor signs using subcortical biomarkers relative to two thresholds. Detector parameters were optimized using patient training data across wake/sleep and medication cycles. Performance was tested using algorithm state logs downloaded daily from patients at home over 47 days. The sleep detector achieved high concordance (mean 88%) with patient reported sleep state. It successfully switched to sleep mode during sleep across 47 days of testing. The motor sign detector adjusted stimulation based on medication fluctuations when patients were awake. Discriminating sleep is crucial for chronic embedded adaptive DBS, as biomarkers are influenced by sleep. This study demonstrates a crucial development in the field of adaptive deep brain stimulation for neurological and psychiatric indications. The dual detector design elegantly overcomes this issue by allowing independent tracking of sleep and disease states on different timescales appropriate for each. Enabling adaptive DBS systems to respond intelligently to sleep could improve outcomes and quality of life for patients. #neurosurgery #deepbrainstimulation #adaptivelearning #parkinsons #mentalhealth

An exciting new study reveals the promise of light therapy for those with Alzheimer’s Disease. Light therapy is a non-pharmacological treatment that targets the brain’s sleep modulator. In this study, the use of light therapy significantly improved sleep efficacy and stabilised circadian rhythms along with markedly reducing psycho-behavioural symptoms in their sample of Alzheimer’s patients. They included 598 individuals across 7 countries, highlighting the broad applicability of this treatment option to a wider population. If complemented by further trials, validating the safety and efficacy of this treatment, light therapy could be a promising treatment option for Alzheimer’s disease. Read more at the link below. _______ #Alzheimers #AlzheimersDisease #LightTherapy #Sleep #SleepHealth #CircadianRhythm #ClinicalTrial #Neurology #AlzheimersResearch #BrainHealth #Dementia #AgingWell #HealthyAging

📢 Review Paper Sharing-Vol. 22 No. 5 💕 Title: Derailment of Sleep Homeostatic Plasticity Affects the Most Plastic Brain Systems and Carries the Risk of Epilepsy 🤵 Authors: Peter Halász*, Igor Timofeev, Anna Szűcs 🔔 Full Text: https://lnkd.in/guY-c88D 🔑 Keywords: sleep homeostatic plasticity epileptic derailment of functional brain networks system epilepsy 😎Welcome to your reading! #Parkinsons #ParkinsonsDisease #Neurology #BrainHealth #MovementDisorders #Dopamine #NeurodegenerativeDiseases #Healthcare #Research #Awareness #Treatment #SupportGroups #PatientCare #Therapeutics #MentalHealth #Neuroscience #CureParkinsons #BrainMapping #Neurobiology #BrainInjury #NeuroscienceNews #NeuroImaging

📢 Review Paper Sharing-Vol. 23 No. 8 💕 Title: Recent Insights into Hippocampal Dysfunction and Neuroplasticity in Sleep Disorders: An Update from Preclinical Studies 🤵 Authors: @Poornima D. E. Weerasinghe-Mudiyanselage, Changjong Moon* 🔔 Full Text: https://lnkd.in/gFH3DFQX 🔑 Keywords: animal model cognition hippocampus sleep disorder synaptic plasticity 😎Welcome to your reading! #Parkinsons #ParkinsonsDisease #Neurology #BrainHealth #MovementDisorders #Dopamine #NeurodegenerativeDiseases #Healthcare #Research #Awareness #Treatment #SupportGroups #PatientCare #Therapeutics #MentalHealth #Neuroscience #CureParkinsons #BrainMapping #Neurobiology #BrainInjury #NeuroscienceNews #NeuroImaging

Neurosom's research partner, the Brain Electrophysiology Lab (BEL), has received $2.2 million in Phase II funding from the National Institutes of Aging to conduct an FDA-monitored clinical trial to determine if Neurosom's Electric Sleep Therapy can improve deep sleep and memory consolidation in seniors with Mild Cognitive Impairment (MCI).  In the Phase I feasibility study, Neurosom scientists, together with colleagues at Wake Forest University (led by Dr. Ruth Benca) and the Portland Veterans Administration Research Foundation (led by Dr. Miranda Lim), demonstrated the ability to train seniors diagnosed with MCI to use the Neurosom Sleep WISP system in their homes to collect EEG (brain waves) and automatically deliver the electrical synchronization therapy to enhance deep sleep. This feasibility study was reviewed by the NIA program officer and found to be successful, thereby warranting the funding for the Phase II (pivotal) clinical trial. Neurosom scientists are planning an investor webinar in the near future to provide updates on progress in the preparation and launch of the clinical trial.  Neurosom remains committed to testing its Electric Sleep Therapy in adults with insomnia, and plans to fund an FDA clinical trial with capital raised over the RedCrow platform.  For investors, the NIA decision to provide non-dilutive funding for the MCI clinical trial provides important validation of the Phase I feasibility study results and advances the incremental de-risking of the investment opportunity. www.neurosom.net #sleep #sleeptherapy #sleep2024

Takeda's TAK-861 demonstrates promise in enhancing wakefulness, as indicated by a phase 1 trial in healthy men. This development may pave the way for a novel approach to treat sleep-related conditions like #narcolepsy. #Neurology #Research Read: https://lnkd.in/efse2VbE