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Type of Constipation : Primary Constipation Secondary Constipation One of the leading cause of Primary Constipation : Irritable Bowel Syndrome (IBS) - Constipation. Constipation alternates Diarrhea that can lead to Irritable Bowel Syndrome (IBS). Causes of Secondary Constipation : Pregnancy Side effects of Medications Endocrine disorders Neurological disorders Vascular collagen & Muscle disorders Suffering from Malignant Tumors like Ovarian Cancer or Colorectal Cancer Mechanical disorders Metabolic disorders

Could a drug used to support pregnancy silently increase cancer risk in the next generation ❓ Unfortunately yes! 😓 Hydroxyprogesterone caproate, known as Primolut Depot, a synthetic hormone used to prevent miscarriage and preterm labour Recent studies about Primolut Depot showed the potential increased risk of cancer in offsprings , suggesting a higher likelihood of colorectal and prostate cancers in adults whose mothers used the drug while pregnant Links: https://lnkd.in/dxezjmy3 https://lnkd.in/dJgmCeu9 https://lnkd.in/dK73eYD2 #clinicalpharmacy #clinicalpharmacist #pharmacotherapy #bcps #pharmacy #pharmacist

You (as a physician )have to know that: =Heparin can result in thrombocytopenia by two main mechanisms as described in the comments =A positive direct Coombs test is seen in up to 10% of patients who receive alpha-methyldopa,an antihypertensive that is sometimes used in pregnancy. In these patients, IgG antibody is directed against the Rh complex of red cells. Hemolysis may be severe but improves within several weeks after cessation of the medication. =Ticagrelor, a platelet P2Y12 receptor inhibitor, cause bleeding, dyspnea (~15% of patients), and ventricular pauses, which are typically asymptomatic. Dyspnea, when present, usually occurs soon after initiating therapy and is self-limited. The mechanism is unknown. =Procainamide may cause a syndrome resembling systemic lupus erythematosus (SLE) consist of polyarthralgias, pleuritis, and photosensitive rashes, but unlike conventional SLE, nephritis and central nervous system complications are very rare, note that antinuclear antibody (ANA) are positive. Discontinuation of procainamide typically results in improvement of symptoms within a few days to weeks. However, ANA levels may remain elevated for years.

Fertility Preservation and Assisted Reproduction in Patients With Breast Cancer Interrupting Adjuvant Endocrine Therapy to Attempt Pregnancy Journal of Clinical Oncology TAKE-HOME MESSAGE In this international, single-arm, prospective study, patients with early hormone receptor–positive breast cancer who desired future pregnancy underwent a temporary interruption of adjuvant endocrine therapy to attempt pregnancy. Among 497 evaluable patients, 74% reported at least one pregnancy. Higher pregnancy rates were observed in women with embryo/oocyte cryopreservation at breast cancer diagnosis followed by embryo transfer after endocrine therapy interruption. Short-term risks of recurrence were not increased. Women of childbearing age with hormone receptor–positive breast cancer should be evaluated by a fertility specialist prior to systemic therapy.

For our new followers who may not know it yet, the purpose of the BioExpert Network (BEN to our friends) is to review the research proposals of #biotechnology start-ups that come to Capital Cell looking for #funding. As the first step in our strict vetting process, only those companies that get a positive evaluation from the BEN move forward with a #funding campaign. One of the companies who successfully completed the BEN review process and did a funding campaign with Capital Cell back in 2020 is OXOLIFE, who have now announced great results in their Phase II #clinicaltrials.

Nipocalimab Trial Highlights Promise for Treating Rare Blood Disorders in Pregnancy 🧪👶 Recent clinical trials suggest that nipocalimab could revolutionize the treatment of haemolytic disease of the foetus and newborn (HDFN) 🩸, a rare but serious blood disorder. Data from the Phase II UNITY study demonstrate that nipocalimab may benefit foetuses, newborns, and expectant mothers by delaying or preventing anemia and reducing the need for intrauterine blood transfusions in high-risk pregnancies 🤰. Insights from the Phase II Study: The study included pregnant women who had previously experienced foetal loss or required early intrauterine transfusions due to HDFN. After administering intravenous nipocalimab between 14 and 35 weeks of gestation, 54% of participants achieved a live birth at or after 32 weeks without the necessity for transfusions 👶. Additionally, some newborns did not require post-birth transfusions, and none developed foetal hydrops, a severe complication of HDFN 💉. Potential and Future of Nipocalimab: Johnson & Johnson confirmed that nipocalimab is currently the sole therapy in clinical development specifically for HDFN 🧬. Dr. Kenneth Moise Jr., the lead investigator and a professor at Dell Medical School at The University of Texas at Austin, emphasized nipocalimab's potential to treat various alloimmune conditions affecting foetuses, such as foetal/neonatal alloimmune thrombocytopenia and immune-mediated congenital heart block 🧠. Dr. Moise Jr. added that if further research supports nipocalimab's use in treating HDFN, it could significantly improve the safety and ease of managing such pregnancies 🩺. The promising results from the Phase II trial were published in the New England Journal of Medicine 📄, paving the way for a larger Phase III study. If approved, nipocalimab would represent the first non-surgical treatment option for high-risk pregnancies affected by HDFN 🔬. In related news, the National Institute for Clinical Excellence (NICE) recently recommended a new drug for haemolytic anemia patients, marking progress in the field of blood disorder treatments 💊. . . . #viral #trending #explore #india #texas

The Importance of Beta-HCG Marker in Diagnostics: Beta-Human Chorionic Gonadotropin (beta-HCG) is a crucial marker used in various diagnostic applications. Our Fluorescence Immunoassay Analyzer offers precise and reliable beta-HCG testing, which is essential for: 1.) Pregnancy Detection: Early and accurate detection of pregnancy. 2.) Cancer Monitoring: Identifying and monitoring certain cancers, such as trophoblastic tumors and testicular cancer. 3.) Ectopic Pregnancy: Early detection of ectopic pregnancies, ensuring timely medical intervention. By incorporating beta-HCG testing, healthcare professionals can provide better patient care through accurate and timely diagnostics. For business inquiries or to learn more about our product, please contact us: 📞 0207863866/0207863223 📧 info@bifourmedical.co.ke #BetaHCG #HealthcareInnovation #DiagnosticTools #FluorescenceImmunoassay #LaboratoryExcellence #MedicalTechnology #PatientCare #EarlyDetection #CancerMonitoring

📢Newly Cited Paper Sharing: The role of complement component C1q in angiogenesis 👥 Authors: Mariagiulia Spazzapan, Silvia Pegoraro, Chiara Agostinis, Roberta Bulla 🔑 Keywords: #Angiogenesis, #C1q, #endothelialcells, #angiogenicfactors 🎯 "The complement component C1q plays a role as a pro-angiogenic factor in different contexts, acting in a complement-independent way. For example, this molecule is able to foster the remodeling of the spiral arteries for a physiological pregnancy and to promote the wound healing process. It is also involved in angiogenesis after post-stroke ischemia. Furthermore, it has a role in supporting the tumor vessel growth. Given its role in promoting angiogenesis both under physiological and pathological situations, other studies are needed to understand its potential therapeutic implications." 🔗 Read the full article: https://lnkd.in/drhnBC4U

Approximately seven per cent of pregnant women in North America consume cannabis because it's perceived as a safe option to help manage nausea and anxiety. While tetrahydrocannabinol (THC), the psycho-active ingredient in cannabis, has been found to be dangerous to the fetus and offspring, up until now there has been little literature focusing on cannabidiol (CBD), the major non-psycho-active component. But a new study from Schulich School of Medicine & Dentistry's Hardy Lab, led by professor Dan Hardy and PhD Candidate Kendrick Lee, found exposure to CBD during pregnancy led to male offspring exhibiting early deficits in cardiac function. "The effect of CBD on fetal development and offspring had never been studied like this before, so we mimicked the dose range found in human umbilical cord tissues. This study, which uncovered links to post-birth glucose intolerance, was the first to show that CBD, not just THC, is not safe for offspring exposed during pregnancy," Hardy said. Read more: https://brnw.ch/21wH9ec