I love this kind of medical discovery: the microcosmos. It is obvious now that there are many organelles and cell functions of the human body that we don't know exist yet. We often wonder about the macro cosmos and don't pay much attention to the awe that exists in the microcosmos. Many things are to be discovered yet. I am excited about this news.
52k | TMS | Cell Therapy | Healthcare | Neuromodulation | Biotech | Business Development at Magstim
🌎 The World of Migrasomes 🌎
The migrasome is a newly discovered organelle produced by migrating cells. As cells migrate, long and thin retraction fibers are left in their wake. On these fibers, we discovered the production of a pomegranate-like structure, which we named migrasomes.
The production of migrasomes is highly correlated with the migration of cells. Currently, it has been demonstrated the migrasomes exhibit three modes of action: release of signaling molecules through rupturing or leaking, carriers of damaged mitochondria, and lateral transfer of mRNA or proteins.
Credit to The National Institutes of Health for the information and Lilian Chen for the great video.
#Science#Neuroscience#Healthcare#Biology
🎥 #Webinar Highlights 🎥
Dr. Michal Millrod discusses the validation process for differentiating neurons from healthy control and Alzheimer’s Disease cell lines using immunocytochemistry (ICC). The focus of these tests is to confirm that neurons from both types of cell lines express common neuronal markers. For further investigation into the differences related to Alzheimer's Disease and healthy control lines, check out the full webinar using the link below:
Link: https://lnkd.in/eRgVZeem#Webinar#ElixirgenScientific#WebinarHighlights#Biotechnology#Neuroscience
We’re excited to share that our recent research paper, "Activation of the 5-HT1A Receptor by Eltoprazine Restores Mitochondrial and Motor Deficits in a Drosophila Model of Fragile X Syndrome," has been accepted for publication in the International Journal of Molecular Sciences! 🎉
This breakthrough study reveals the potential of targeting the 5-HT1A-mitochondrial axis as a promising therapeutic strategy for Fragile X Syndrome, offering new avenues for addressing intellectual and motor impairments.
A heartfelt thank you to our incredible team, Anna Vannelli and Vittoria Mariano, for their relentless efforts, and to all the members of the Bagni Lab for their invaluable support. A special shoutout to our mentor, Claudia Bagni, for her unwavering guidance and the opportunity to be part of this impactful research. FBM UNIL - Faculté de biologie et de médecine de l'Université de Lausanne 😉
This work is particularly significant as it is featured in a special issue dedicated to the memory of Professor Suzanne Eaton (1959-2019), whose legacy continues to inspire our scientific endeavors.
Stay tuned for more exciting updates! #FragileXSyndrome#Neuroscience#Mitochondria#Serotonin#Research#ScientificBreakthrough#Genetics#FXSTherapy#InMemoryOfSuzanneEaton#MolecularScience#InnovationInScience#Drosophila#Brain#Eltoprazine
Learn more: https://lnkd.in/dr_t8wJ5
📣 I am excited to share that my co-first author publication from my main project during my previous postdoc at The University of Tennessee Health Science Center is now available online in eLife!
🔬We have demonstrated the critical role of Lmx1a as a master regulator gene for the development of the cortical hem, an embryonic signaling center that acts as an organizer for the hippocampus, especially the hippocampal dentate gyrus, one of the few brain regions in which the adult neurogenesis occurs. The RNAseq findings allowed us to identify and characterize the Lmx1a-dependent network of genes that regulate multiple processes throughout brain development ranging from the cortical hem cell-fate induction to migration and differentiation of neural progenitors.
🙌 Huge gratitude to my former supervisor Dr. Viktor Chizhikov, and to the exceptional team who contributed to this research, and a special thanks to Dr. Igor Iskusnykh from my former lab. This work wouldn’t be possible without a support a collaboration of talented colleagues from St. Jude Children's Research Hospital.
Check out the full paper below for more information:
https://lnkd.in/ePJTQb_n#research#elife#publication#corticalhem#lmx1a#hippocampus#dentategyrus#neuroscience#postdoc#neurobiology
Some years ago, I was intently studying time-lapse movies of fluorescently labelled co-cultured cells that transferred contents between each other. I had seen that large amounts of material were transferred, especially from fibroblasts to cancer cells, but could not easily see how it was happennning.
The recordings were ‘con-focal stacks’, so I could focus up and down the cells to see at what level events occurred. Doing so, I noticed cell debires was clinging to the culture surface in a net-like pattern, and for a day or two I thought that perhaps the transfers I was seeking might be just the slow accumulation of these fragments as cells migrated about. But look how I might, I couldn’t see any clear uptake of these net-distributed particles.
It was then that I first stumbled across a dramatic and unambiguous episode of what I later came to call ‘Cell-Projection Pumping’ (CPP), which we subsequently demonstrated accounted for the transfers I had been studying and also for the changes in cancer cell behaviour we had seen before.
I put the ‘net of debris’ aside, and focussed on what I was looking for, but now see how on that occasion, I had failed to follow an interesting scientific observation - what is now called ‘the migrasome’.
It is in some manner ironic, because I am quite certain that many other workers have noticed incidental episodes of CPP, but have like I did for the migrasome, not really ‘seen it’ because their interest lay elsewhere.
I wonder how many other interesting discoveries are briefly noticed and then ignored, waiting for someone else to pick them up and chase?
52k | TMS | Cell Therapy | Healthcare | Neuromodulation | Biotech | Business Development at Magstim
🌎 The World of Migrasomes 🌎
The migrasome is a newly discovered organelle produced by migrating cells. As cells migrate, long and thin retraction fibers are left in their wake. On these fibers, we discovered the production of a pomegranate-like structure, which we named migrasomes.
The production of migrasomes is highly correlated with the migration of cells. Currently, it has been demonstrated the migrasomes exhibit three modes of action: release of signaling molecules through rupturing or leaking, carriers of damaged mitochondria, and lateral transfer of mRNA or proteins.
Credit to The National Institutes of Health for the information and Lilian Chen for the great video.
#Science#Neuroscience#Healthcare#Biology
I love this kind of medical discovery: the microcosmos. It is obvious now that there are many organelles and cell functions of the human body that we don't know exist yet. We often wonder about the macro cosmos and don't pay much attention to the awe that exists in the microcosmos. Many things are to be discovered yet. I am excited about this news.
52k | TMS | Cell Therapy | Healthcare | Neuromodulation | Biotech | Business Development at Magstim
🌎 The World of Migrasomes 🌎
The migrasome is a newly discovered organelle produced by migrating cells. As cells migrate, long and thin retraction fibers are left in their wake. On these fibers, we discovered the production of a pomegranate-like structure, which we named migrasomes.
The production of migrasomes is highly correlated with the migration of cells. Currently, it has been demonstrated the migrasomes exhibit three modes of action: release of signaling molecules through rupturing or leaking, carriers of damaged mitochondria, and lateral transfer of mRNA or proteins.
Credit to The National Institutes of Health for the information and Lilian Chen for the great video.
#Science#Neuroscience#Healthcare#Biology
Bio-protocol's latest issue is now live! https://lnkd.in/gYXdeH-M
Dive in and discover various insightful protocols on #cellbiology, #microbiology, #neuroscience, and #stemcells
On the cover: Quantitative bioimaging of host and parasite nascent proteomes during Plasmodium berghei liver stage development.
The nascent proteome of P. berghei-infected HepG2 cells (pseudo-colored red) visualized using o-propargyl puromycin conjugated to alexaFluor555 following 4-hr treatment with a parasite selective translation inhibitor (shown on the right) and DMSO control (shown on the left). Single channel images of parasite cytoplasmic marker (PbHsp70, shown in green) and Hoechst labeled DNA (shown in blue) are used for image segmentation and masking to define the parasite objects and HepG2 nuclei objects, where the fluorescence intensity of the labeled HepG2 and Plasmodium nascent proteomes are quantified.
Find more details about this protocol by James McLellan, Andreu G., and Kirsten Hanson at The University of Texas at San Antonio: https://lnkd.in/gxkw9qk6
Do you have a protocol that can contribute to scientific clarity and reproducibility ?
Visit us at https://lnkd.in/dt_igxRi and explore publishing with Bio-protocol at https://lnkd.in/gR3QGYz6!
#openaccess#reproducibility#lifesciences#research
