Liliane Brunner Halbach’s Post

🔬 Stanford University School of Medicine-led Study Unveils Autoimmune Disease Risk in Women 👩🔬 Lead Author: Dr. Howard Chang, MD, PhD 🧪 A groundbreaking study from Stanford Medicine, led by renowned dermatologist and geneticist Dr. Howard Chang, has made a significant breakthrough in understanding why women are more susceptible to autoimmune diseases. This research has unraveled the molecular mechanisms behind this gender disparity, providing a new perspective on autoimmune conditions. 🧬 The study focuses on the X chromosome in female cells. In every female cell, one X chromosome is disabled to maintain appropriate protein levels. However, this process creates unfamiliar molecular structures that can trigger the immune system to produce antibodies against a woman's own tissues. 🔎 This phenomenon has a profound impact on autoimmune disorders like rheumatoid arthritis, multiple sclerosis, and scleroderma, which show a higher incidence in women. For instance, the female-to-male ratio for lupus is 9 to 1, and for Sjogren’s syndrome, it's 19 to 1. 🧑🔬 The team's findings suggest that the production of Xist - a long noncoding RNA molecule involved in X-chromosome inactivation - leads to the formation of complexes that can elicit a strong immune response. This discovery is vital in understanding the high rate of autoimmunity in women compared to men. https://lnkd.in/daWBXiJH #AutoimmuneDisease #WomenInMedicine #Genetics #MedicalResearch #CME #PhysicianInsightshttps

🔬 Unraveling the Gender Gap in Autoimmune Diseases 🌟 Pioneering Study by Stanford Medicine - 1.0 CME We're excited to share a groundbreaking study led by Stanford Medicine that shines a light on the longstanding mystery of why autoimmune disorders predominantly affect women. The study, adeptly conducted by Howard Chang, MD, PhD, and his team, reveals that a molecule produced by the X chromosome can result in a woman's immune system turning against her own tissues. 🧬 Study Insights: The research links the disparity in autoimmune diseases between women and men to the fundamental differences in X chromosomes. Genetic mechanisms, including the inactivation of one X chromosome in females, create molecular structures that may trigger autoimmunity. 📊 Implications: The discovery could lead to better predictive measures for autoimmune disorders, offering a chance to intervene before the diseases fully develop. This marks a significant step in understanding and potentially curbing the higher prevalence of conditions like lupus, multiple sclerosis, and rheumatoid arthritis among women. 🚀 The study not only provides invaluable insights into the biological underpinnings of autoimmune diseases but also emphasizes the necessity of including female genetic expression in medical research. https://ow.ly/1aUE50QxqQm #AutoimmuneDiseases #StanfordMedicine #Genetics #WomenInMedicine #HealthcareResearch

☑️ *READ ASTRACT BELOW:* Keywords: Pulmonary large cell neuroendocrine carcinoma; machine learning; primary tumor; prognosis; resection; survival. Background: The post-surgical prognosis for Pulmonary Large Cell Neuroendocrine Carcinoma (PLCNEC) patients remains largely unexplored. Developing a precise prognostic model is vital to assist clinicians in patient counseling and creating effective treatment strategies. Research design and methods: This retrospective study utilized the Surveillance, Epidemiology, and End Results database from 2000 to 2018 to identify key prognostic features for Overall Survival (OS) in PLCNEC using Boruta analysis. Predictive models employing XGBoost, Random Forest, Decision Trees, Elastic Net, and Support Vector Machine were constructed and evaluated based on Area Under the Receiver Operating Characteristic Curve (AUC), calibration plots, Brier scores, and Decision Curve Analysis (DCA). Results: Analysis of 604 patients revealed eight significant predictors of OS. The Random Forest model outperformed others, with AUC values of 0.765 and 0.756 for 3 and 5-year survival predictions in the training set, and 0.739 and 0.706 in the validation set, respectively. Its superior validation cohort performance was confirmed by its AUC, calibration, and DCA metrics. Conclusions: This study introduces a novel machine learning-based prognostic model with a supportive web-based platform, offering valuable tools for healthcare professionals. These advancements facilitate more personalized clinical decision-making for PLCNEC patients following primary tumor resection. Liang M, Expert Rev Anticancer Ther. 2024 Oct;24(10):1041-1053. doi: 10.1080/14737140.2024.2401446. Epub 2024 Sep 9. PMID: 39242355. #Gesundheit #Bildung #Fuehrung #Coaching #Mindset #Motivation #Gehirn #Neuroscience #Psychologie #Persoenlichkeitsentwicklung #Kindheit #KeyNoteSpeaker #Humangenetik #Biochemie #Neuroleadership #Ernaehrung #Transformation #Stress #Demografie #Gender #Age #interkulturelleKompetenz #Epigenetik #Veraenderung #EmotionaleIntelligenz #Change #Gesellschaft #Organisationsentwicklung #Philosophie #Beratung # Quantum

🧬 Even our genes are gender biased! A recent groundbreaking study conducted by Stanford University has shed light on why "women" are at a higher risk of autoimmune diseases. Autoimmune diseases, such as rheumatoid arthritis, multiple sclerosis, and lupus, affect millions of people worldwide, and the majority of those affected are women. But why is this the case? The Stanford study discovered that genetic factors play a crucial role in this gender disparity. It revealed that certain genes on the X-chromosome, which women have two of, are associated with an increased susceptibility to autoimmune diseases. Here are some key takeaways from the study: - Women's immune system genes have a higher sensitivity to triggers that can lead to autoimmune responses. - The X-chromosome carries a significant number of genes related to immune system regulation. - Women may also have an imbalance in the ratio of certain immune cells due to genetic differences. This groundbreaking research suggests that the biological differences between genders are not limited to reproductive organs but extend to our immune systems as well. Awareness about these gender disparities is essential in early detection, prevention, and personalized treatment of autoimmune diseases. By understanding the genetic factors that contribute to increased susceptibility in women, medical professionals can tailor treatments accordingly. Let's spread the word and raise awareness about this important study! Share this post to empower women and encourage further research. Together, we can make a difference! #Women'sHealth #AutoimmuneDiseases #GeneticResearch #StanfordStudy #womenhealth

📍 Study Offers New Clues to Why Most People with Autoimmune Diseases Are Women Stanford University School of Medicine-led study shows why women are at greater risk of autoimmune disease Excerpt: As many as 50 million Americans have one of more than 100 known autoimmune diseases, making it the third most prevalent disease category, surpassed only by cancer and heart disease. This category of disease has also long held a mystery: Why are most people with a chronic autoimmune condition—as many as four out of every five—women? This sex-biased trend includes autoimmune diseases such as rheumatoid arthritis, multiple sclerosis, scleroderma, lupus, Sjögren’s syndrome, and many others. Now, exciting findings from a study supported in part by #NIH provide a clue to why this may be the case, with potentially important implications for the early detection, treatment, and prevention of autoimmune diseases. The new evidence, reported in the journal Cell, suggests that more women develop autoimmune diseases than men due in part to the most fundamental difference between the #biological #sexes: that females have two X chromosomes, while males have an X and a Y. More specifically, it has to do with molecules called Xist (pronounced “exist”), which are encoded on the X chromosome and transcribed into long non-coding stretches of RNA, only when there are two X chromosomes. Throughout the mammalian kingdom, biological sex is determined by the presence, in every female cell, of two X chromosomes. Male cells pack just one X chromosome, paired with a much shorter one designated the Y chromosome. Those long #Xist #molecules wind themselves around sections of just one of a female’s two X chromosomes, shutting down the extra X chromosome in a process known as X-chromosome inactivation. It’s an essential process to ensure those cells won’t produce too many proteins encoded on X chromosomes, which would be a deadly mistake. It’s also something that males, with a single X chromosome and much smaller Y chromosome carrying almost no working genes, don’t have to worry about. The researchers also examined blood samples from 100 people with autoimmune conditions and found they had antibodies to many of their own Xist complexes. Some of those antibodies also appeared specific to a certain autoimmune disorder, suggesting that they might be useful for tests that could detect autoimmunity or particular autoimmune conditions even before symptoms arise. There are still many questions to explore in future research, including why men sometimes do get autoimmune conditions, and what other key triggers drive the development of autoimmunity. But this fundamentally important discovery points to potentially new ways to think about the causes for the autoimmune conditions that affect so many people in communities here and around the world. Read➡️ https://lnkd.in/ewQwdrRJ #sexdifferences #womenhealth #biologicalsex #xchromosome #autoimmunedisease #XIST #RNAbindingprotein #autoantibody

Immune cells carry a long-lasting 'memory' of early-life pain In recent years, a growing body of research has shown that the human body can “remember” the pain of newborn injuries—including life-saving surgeries—all the way into adolescence. These early experiences appear to change how a child’s pain response system develops at a genetic level, resulting in more intense reactions to pain later in life. Such changes also appear to occur more often among females. Now research pinpoints how and where the genetic changes that create such long-lasting pain memory occur. According to their study, published in the journal Cell Reports, the key changes are occurring in developing macrophage cells—one of the major elements of the immune system. The experiments show that male mice experiencing similar early-life injury show the same epigenetic changes but did not sustain the same long-term pain memory as females. Further testing also showed that changes, occurring in a gene called p75NTR, can be found in human macrophage cells. In female mice, the pain memory effects were detected for more than 100 days after the initial injury. Incisions caused stem cells in the bone marrow to generate macrophages that were “primed” to respond more intensely to injuries, which in turn increases pain. In humans, a similar timeframe would be roughly 10-15 years. #ScienceMission #sciencenewshighlights https://lnkd.in/gjMbXjCr

💡⭕️ New preprint 🔬🧬: "Local patterns of genetic sharing challenge the boundaries between neuropsychiatric and insulin resistance-related conditions." We're pleased to announce our recent study now published as a preprint on medRxiv. This research explored the genetic relationships between 🍬 insulin resistance-related conditions and a range of 🧠 neuropsychiatric disorders at the level of individual genomic regions 🧬, while investigating likely causal shared genetic factors and biological mechanisms at play. Key aspects of our study: - Through Local Analysis of [co]Variant Association (LAVA), we identified 109 unique genomic regions with significant local genetic correlations, challenging traditional disease categorization and boundaries. - Significant genetic correlations were also found within the Major Histocompatibility Complex (MHC) region, known for its immunological functions, indicating its involvement in the genetic overlap between the studied conditions. - The study reveals local genetic correlations for conditions like Alzheimer’s disease, bipolar disorder, and Tourette’s syndrome with insulin resistance-related conditions, although previous studies did not find any global genetic correlation. - Our findings also highlight pathways and potential therapeutic targets that could lead to novel treatment strategies for insulin resistance-neuropsychiatric multimorbidity. 🔗 Read the full manuscript for a comprehensive understanding of our research and its implications: https://lnkd.in/dyUBb-6p 📖 The importance of this work: Our findings encourage a more integrated and holistic approach to understanding and treating metabolic and neuropsychiatric comorbidities, reflecting the complex interplay between genetic factors across traditionally separate disease domains. #PsychiatricGenomics #MetabolicHealth #Genomics #PrecisionMedicine #InsulinResistance #mood #psychosis Radboudumc Janita Bralten European College of Neuropsychopharmacology (ECNP) concentris research management GmbH A chord plot showing local genetic correlations between insulin resistance-related conditions and neuropsychiatric disorders ⬇️

💎💎💎Whatsapp!! 💎💎💎Multiple Sclerosis & Myelin Sheath #Myelin #Sheath Damage Mediated by Epigenetic #Remedy in #Multiple #Sclerosis Despite being one of the most common and well-known #neurodegenerative #diseases, multiple sclerosis ( #MS) remains difficult to treat. However, new research from scientists at Cincinnati Children’s Hospital Medical Center and elsewhere points to a #potential #therapeutic approach that appears to overcome difficulties faced by other attempts. Their work is described in a new Cell paper titled, “#Small_molecule_induced epigenetic rejuvenation promotes SREBP condensation and overcomes barriers to #CNS myelin regeneration.” According to the paper, the researchers treated mouse models of multiple sclerosis and myelin #organoids with an inhibitor molecule called epigenetic-silencing-inhibitor-1 (ESI1) that appears to improve both myelin production and poor #cognitive function associated with MS and similar #demyelinating diseases. It works at the epigenetic level to essentially restart myelin production by #oligodendrocytes present in the MS lesions... ➡ 💎 You can find more pieces of work by clicking here. https://lnkd.in/eSG67K5G https://lnkd.in/dB3s88ei #Myelin #Sheath #Epigenetic #Remedy #Multiple #Sclerosis #neurodegenerative #diseases #multiple_sclerosis ( #MS)

🎉 Congratulations to A/Prof Gina Ravenscroft, our own Dr Sarah Beecroft and the team behind this research breakthrough published in Nature Communications. 🧬 This study, a collaboration between Harry Perkins Institute of Medical Research, the University of Pavia, Pawsey Supercomputing Research Centre, and other global institutions, with support from Bioplatforms Australia, the Australian Cancer Research Foundation, and the Centre for Advanced Cancer Genomics, has uncovered a link between CCG repeat expansions in the ABCD3 gene and Oculopharyngodistal myopathy (OPDM) in Europeans. 🧠 OPDM is a rare inherited muscle disease whose symptoms include drooping eyelids, dysphagia, and distal muscle weakening. This research found that individuals with OPDM had between 118 and 694 CCG repeats in the ABCD3 gene, compared to 7 repeats in unaffected family members. This discovery significantly advances our understanding of OPDM and highlights the impact of genetic changes on muscle function. #Genetics #Research #OPDM #Supercomputing #PawseyCentre #ScientificDiscovery #SaturdayScience #NCRISimpact

Weekly Update: Stay up-to-date on the latest research & articles! 1) Newly found genetic variant defends against Alzheimer's disease : Scientists studying the brain have discovered a genetic variation that provides protection against Alzheimer's disease in individuals with a heightened susceptibility, potentially opening doors to novel methods for shielding people from this condition. Reference : https://lnkd.in/ge3w_tUc 2) Safety of a potential new treatment to manage complications from sickle cell disease : A recent study proposes that a medication used for pulmonary arterial hypertension may also help manage hypertension and organ damage in sickle cell disease. In a trial with 130 patients, the drug riociguat was found safe, improved blood pressure, and showed potential for enhancing heart function. Reference : https://lnkd.in/gW89E33a 3) Research could unlock more precise prognoses and targeted treatments for children with cancer : Researchers have identified new variations in neuroblastoma, leading to more precise prognosis and targeted therapies for this childhood cancer. They discovered three distinct subcategories, each with unique genetic traits, prognostic outlooks, and traits, providing insights into tailored treatments. Reference : https://lnkd.in/gdjy7Naa 4) Connecting lab-grown brain cells provides insight into how our own brains work : Scientists have devised a method to link lab-grown neural 'organoids' using axonal bundles, mimicking connections found in the human brain. This advancement enables more accurate representation of brain networks in laboratory settings, enhancing research on network-related brain disorders. Reference : https://lnkd.in/g_Aiw4qP 5) New study highlights the benefit of touch on mental and physical health : Through an extensive analysis, scientists have revealed the ways in which agreed-upon physical contact can enhance both the physical and mental health of an individual. Reference : https://lnkd.in/dM_AEJCp 6) New drug prevents flu-related inflammation and lung damage : Research indicates that a newly developed medication can curb excessive inflammation while enabling the immune system to effectively combat the virus, even when administered later during the infection. Reference : https://lnkd.in/gr_jn5_m Follow us for more! #research #update #weekly #articles #reasearchpublication #science #bioinformatics #biotechnology #lifescience