Lindsey Kemp’s Post

Impact of CRISPR in drug discovery "CRISPR-based screens of cell lines, and phenotypic readouts such as cell growth, can facilitate the discovery of genetic interactions that could be therapeutic targets. Machine learning of these datasets and other information can be used to model drug effects on tumor microenvironments and better predict effects on patients." This technology can be applied to any disease, particularly for those with clear cellular phenotypes, such as lysosomal storage diseases. This Perspective article, focused on cancer drug discovery, was published in Science: https://lnkd.in/eR55ENje. #genetics #genomics #precisionmedicine #genomicmedicine #cancer #brain #neurology #neurodegeneration #neuroscience #neuroinflammation #lysosomalstoragedisease #drugdiscovery #drugdevelopment #ai #omics #biotechnology #pharma #innovation #research #science #sciencecommunication

🧬 Drive Innovation in Signal Transduction Research with Aladdin’s Phospho Antibodies 🔬 Protein phosphorylation plays a critical role in regulating cellular activities, making it a focal point for research in areas such as cancer, neurobiology, and immunology. Aladdin’s Phospho Antibodies are specifically designed to offer high specificity and sensitivity, enabling researchers to accurately detect and study phosphorylated proteins. Partner with Aladdin to advance your research and achieve reliable, reproducible results that can propel your discoveries to new heights. 🔗Aladdin Scientific: https://lnkd.in/gMUQN2Qa #PhosphoAntibodies #CellSignaling #Proteomics #ScientificResearch #BiomedicalInnovation #SignalTransduction #AladdinScientific

🧬 Drive Innovation in Signal Transduction Research with Aladdin’s Phospho Antibodies 🔬 Protein phosphorylation plays a critical role in regulating cellular activities, making it a focal point for research in areas such as cancer, neurobiology, and immunology. Aladdin’s Phospho Antibodies are specifically designed to offer high specificity and sensitivity, enabling researchers to accurately detect and study phosphorylated proteins. Partner with Aladdin to advance your research and achieve reliable, reproducible results that can propel your discoveries to new heights. 🔗Aladdin Scientific: https://lnkd.in/ginDytyx #PhosphoAntibodies #CellSignaling #Proteomics #ScientificResearch #BiomedicalInnovation #SignalTransduction #AladdinScientific Aladdin scientific： https://lnkd.in/gWCqgVvb

☑️ *READ ASTRACT BELOW:* Keywords: Cell therapy; Midbrain organoids; Parkinson's disease; iPSC Parkinson's disease (PD) is a neurodegenerative disease characterized by the degeneration of dopaminergic (DA) neurons in the substantia nigra and loss of DA transmission in the striatum, thus making cell transplantation an effective treatment strategy. Here, we develop a cellular therapy based on induced pluripotent stem cell (iPSC)-derived midbrain organoids. By transplanting midbrain organoid cells into the striatum region of a 6-OHDA-lesioned PD mouse model, we found that the transplanted cells survived and highly efficiently differentiated into DA neurons. Further, using a dopamine sensor, we observed that the differentiated human DA neurons could efficiently release dopamine and were integrated into the neural network of the PD mice. Moreover, starting from four weeks after transplantation, the motor function of the transplanted mice could be significantly improved. Therefore, cell therapy based on iPSC-derived midbrain organoids can be a potential strategy for the clinical treatment of PD. Fu CL, Heliyon. 2024 Jan 9;10(2):e24234. doi: 10.1016/j.heliyon.2024.e24234. PMID: 38293351; PMCID: PMC10826648. #Gesundheit #Bildung #Fuehrung #Coaching #Mindset #Motivation #Gehirn #Neuroscience #Psychologie #Persoenlichkeitsentwicklung #Kindheit #KeyNoteSpeaker #Humangenetik #Biochemie #Neuroleadership #Ernaehrung #Transformation #Stress #Demografie #Gender #Age #interkulturelleKompetenz #Epigenetik #Veraenderung #EmotionaleIntelligenz #Change #Gesellschaft #Organisationsentwicklung #Philosophie #Beratung # Quantum

Potential applications of patient-derived organoids (PDOs). PDOs can be derived from surgically resected tumor tissue or tumor biopsy and organoids can also be derived from the normal tissue surrounding the tumor. Gene-editing and screening methods allows the introduction of oncogenic mutations and thus have the potential for studying the tumorigenesis process. Identification of gene–drug associations through genomic profiling permits precision oncology through drug and immunotherapeutic screens. PDOs can be expanded and cryopreserved to establish living organoid biobanks for basic and clinical research purposes https://lnkd.in/e_9YRweb #Gesundheit #Bildung #Fuehrung #Coaching #Mindset #Motivation #Gehirn #Neuroscience #Psychologie #Persoenlichkeitsentwicklung #Kindheit #KeyNoteSpeaker #Humangenetik #Biochemie #Neuroleadership #Ernaehrung #Transformation #Stress #Demografie #Gender #Age #interkulturelleKompetenz #Epigenetik #Veraenderung #EmotionaleIntelligenz #Change #Gesellschaft #Organisationsentwicklung #Philosophie #Beratung # Quantum

🚀 !Incredible Clinical Trial for Frontotemporal Dementia Begins in the U.S.! 🚀 AviadoBio's ASPIRE-FTD Phase 1/2 Clinical Trial is now open at The Ohio State University Wexner Medical Center! ASPIRE-FTD recruits participants to evaluate AVB-101, a gene therapy designed to stop FTD progression caused by GRN mutations. The study is also ongoing in Europe, and aims to restore progranulin levels! The therapy is delivered to the thalamus via a minimally invasive procedure. Why This Matters: 🧠 FTD impacts those under 65, causing personality changes, behavioral issues, and loss of language and mobility. With no current treatments, this trial offers a new course of therapy. 🧠"People with FTD-GRN have no disease-modifying treatments, and the impact is profound for patients and families," said Dr. James Elder, neurosurgeon at The Ohio State University Wexner Medical Center #GeneTherapy #FTD #NeurodegenerativeDisorders #ClinicalTrials #MedicalResearch #Neurology #Neurosurgery #OhioState #AviadoBio #InnovationInMedicine #GRNMutations #AVB101 #EarlyOnsetDementia #MedicalBreakthroughs Image: Fig. 1a | Intrathalamic gene therapy delivery in sheep. MRI image of sheep skull demonstrating simulated bilateral intrathalamic infusion (blue) into the brain. https://lnkd.in/ebgB5Vz3

I realised I haven't yet shared the biggest achievement of my PhD so far: my first first-author #publication, out in Elsevier's 𝘉𝘳𝘢𝘪𝘯, 𝘉𝘦𝘩𝘢𝘷𝘪𝘰𝘳, 𝘢𝘯𝘥 𝘐𝘮𝘮𝘶𝘯𝘪𝘵𝘺! 👩🔬 https://lnkd.in/dW7_D9DN Key takeaways: 🔬 iPSC-derived neurons from Parkinson's disease patients with duplication of the alpha-synuclein gene show an increased sensitivity to cytoskeletal and functional damage induced by pro-inflammatory cytokines, particularly by IL-17A 🔬 Inhibiting alpha-synuclein oligomerisation rescues the IL-17A-mediated functional pathologies A huge thanks to all collaborators and funding agencies for making this happen! #neuroscience #ParkinsonsDisease #AlphaSynuclein #neuroinflammation #cytokines #research FAU Erlangen-Nürnberg | Universitätsklinikum Erlangen

☑️ *READ DESCRIPTION BELOW:* In vivo modeling of CNS tumors. Human induced pluripotent stem cells (hiPSCs) or embryonic stem cells (hESCs) can be used to generate mutant progenitor cells harboring mutations associated with cancer of the nervous system by CRISPR engineering. These mutant progenitor cells can then be injected into the brain or sciatic nerve of immunocompromised rodents for brain tumor or peripheral nerve tumor modeling studies, respectively Furnari FB, Dis Model Mech. 2024 Feb 1;17(2):dmm050533. doi: 10.1242/dmm.050533. Epub 2024 Feb 14. PMID: 38353122; PMCID: PMC10886724. #Gesundheit #Bildung #Fuehrung #Coaching #Mindset #Motivation #Gehirn #Neuroscience #Psychologie #Persoenlichkeitsentwicklung #Kindheit #KeyNoteSpeaker #Humangenetik #Biochemie #Neuroleadership #Ernaehrung #Transformation #Stress #Demografie #Gender #Age #interkulturelleKompetenz #Epigenetik #Veraenderung #EmotionaleIntelligenz #Change #Gesellschaft #Organisationsentwicklung #Philosophie #Beratung # Quantum

☑️ *READ DESCRIPTION BELOW:* a From human cancer tissue, tumor cells can be isolated and placed in culture to yield spheroids. b Embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) are two common stem cell types used as the cellular source for organoid production. Both ESCs and iPSCs can form a variety of organoid models when given the right signaling cues and extracellular matrix (ECM) https://lnkd.in/emzBEt6h #Gesundheit #Bildung #Fuehrung #Coaching #Mindset #Motivation #Gehirn #Neuroscience #Psychologie #Persoenlichkeitsentwicklung #Kindheit #KeyNoteSpeaker #Humangenetik #Biochemie #Neuroleadership #Ernaehrung #Transformation #Stress #Demografie #Gender #Age #interkulturelleKompetenz #Epigenetik #Veraenderung #EmotionaleIntelligenz #Change #Gesellschaft #Organisationsentwicklung #Philosophie #Beratung # Quantum

𝗠𝗮𝗽𝗽𝗶𝗻𝗴 𝗕𝗿𝗮𝗶𝗻 𝗗𝗲𝘃𝗲𝗹𝗼𝗽𝗺𝗲𝗻𝘁 𝗮𝗻𝗱 𝗙𝘂𝗻𝗰𝘁𝗶𝗼𝗻 𝗧𝗵𝗿𝗼𝘂𝗴𝗵 𝗦𝗶𝗻𝗴𝗹𝗲-𝗖𝗲𝗹𝗹 𝗦𝗲𝗾𝘂𝗲𝗻𝗰𝗶𝗻𝗴 𝗜𝗻𝘀𝗶𝗴𝗵𝘁𝘀 🔬 Exploring Brain Development and Disease Links Through Gene Splicing events 🧠 New study where the brains the brain's RNA isoforms have been mapped, revealing unique gene expression patterns in both mouse and human brains. Their study shows that RNA isoforms, which vary significantly between brain regions, cell types, and over developmental stages, play a critical role in defining cell identity and function. This groundbreaking research, which utilised advanced single-cell sequencing techniques, pave the way for new insights into neurological diseases and brain development. #BrainResearch #Genetics #Neuroscience #SingleCellSequencing #Innovation Source: https://lnkd.in/ecmDKx3k