Louise S. Dalbøge’s Post

View profile for Louise S. Dalbøge, graphic

CSO at Gubra

Can you go from idea to drug candidate in one year? At Gubra, we constantly pursue novel approaches to advance and enable smarter and faster peptide drug discovery. Therefore, we were eager to get started when presented with this exciting challenge “can you make a drug candidate that ticks all the boxes, i.e. potent in vivo efficacy, a long half-life and excellent physicochemical properties. Do it within a year!” With this aim, we exploited our innovative ML-based peptide drug discovery platform ‘streaMLine’ and demonstrated how the platform effectively facilitates accelerated development of novel peptide-based therapeutics. Did we succeed? Yes! And it has been a fun ride! Definitely some ups and downs along the way and many lengthy discussions with the project team. A total of 2688 peptides were synthesized, screened, and analyzed using the ML-guided approach to map out a solution space for generating GLP-1R agonists derived from the secretin backbone. We are happy to present the inner workings of our streaMLine drug discovery platform in the Journal of Medicinal Chemistry Kudos to the amazing team, (Jens Christian Nielsen,Claudia U. Hjørringgaard,Mads Mørup Nygaard, Anita Wester, Lisbeth Elster, Trine Porsgaard, Randi Bonke Mikkelsen, Silas Anselm Rasmussen, Andreas Nygaard Madsen, Morten Schlein, Niels Vrang, Kristoffer Rigbolt). Thanks for making this project a success. If you are into some light summer reading, you can find the full story here: (https://lnkd.in/dsAm7UHE) #drugdiscovery #pushingboundaries #speed #quality

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Impressive achievement in just one year!

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Marcus Bauser

Senior Director / Head Discovery Sciences LEO Pharma

3mo

Congrats, this will be my afternoon read!

Ella Marushchenko

Art director @ Ella Maru Studio Inc. | We create figures, cover images and animation for scientists!

3mo

Going from idea to drug candidate in a year is impressive, Louise S. Dalbøge! What specific ML algorithms were most effective in the peptide selection process for GLP-1R agonists?

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Chris Caster

Executive Director, Program Management at Avenzo Therapeutics

3mo

Great job. Keep it going. We once went from gene to approval in under 2 years.

Hello dear colleague! It was very nice to see your message. I have some interesting peptides on hand that are used to treat serious diseases. I would like to modify them, is there any way I can use your program?

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Westley Cruces

Co-Founder & Chief Science Officer at Colorado Chromatography Labs and an Applied Chemist with a Focus on Medicinal Chemistry and Therapeutics

3mo

Wow that's impressive. I am excited to read this and learn more.

Raju Ninave

PG Research Scholar (Pharmaceutical Chemistry) at The MSU Baroda.

3mo

Drug discovery within a year is quite phenomenal.

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You have 6 months next time

Mary Pitman

Staff Research Scientist, AI Sim @ SandboxAQ

3mo

Congrats, looking forward to reading!

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Surendra Kumar

PhD Student at Central University of Rajasthan, Bandarsindri, Kishangarh, Ajmer

3mo

Congratulations Ma'am

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