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Are you facing a formulation challenge when working with “Stressful API’s” and need to decide which type of chemical bonds to consider for gelling properties and develop robust topical formulations? Here is your last chance to register and discuss with SEPPIC team during this live webinar and advance on your excipient selection knowledge in connection to polymer chemistry. Register on the link to connect with our experts and learn more: https://lnkd.in/gZBeFiRy ✔ Influence of polymer chemistry on topical formulations ✔Criticality of polymers and impact on formulations developments ✔ Selecting the right polymers for challenging topical formulations  ✔ Exploring versatility and functionality of polymers and their role to formulate different products #pharmaceuticalindustry #pharmaceutical #webinar #topical #pharma #formulation #drugdelivery #dermopharma

🔎 Using automated flow chemistry for synthesis of pharmaceuticals 🔎 Organic synthesis remains a key component of the discovery and production of pharmaceutical molecules. Traditional approaches incorporate sequential batch-processes in multi-step synthetic routes to obtain the target products, but require substantial user input and time investment. Automated synthetic procedures represent an attractive option for improving the efficiency, quality, and safety of these processes – as machines can often work faster and more accurately than humans are able to. Continuous-flow chemistry can be effectively employed within an automated setup, and the combination has emerged as a safe and efficient alternative for the synthesis of pharmaceuticals. This review by Zhang and coworkers discusses the latest developments in the automated flow synthesis of pharmaceutical compounds (encompassing large biopharmaceuticals molecules, small drug molecules, and carbohydrates), and also the use of in-line analysis techniques, high-throughout synthesis and machine learning processes that have been employed. Read the review to find out more! 🗒 Recent developments of automated flow chemistry in pharmaceutical compounds synthesis 🌐 https://lnkd.in/eUBzkBv3 ✍ Jiashu Wu, Xingxing Yang, Yourong Pan, Tao Zuo, Zuozhou Ning, Chengxi Li, and Zhiguo Zhang Follow us for more updates from the Journal of Flow Chemistry 📰 #flowchemistry #JFC #flowchemistrysociety #pharma #synthesis #automation

https://bit.ly/46j0yGr - Read the Article here LC/MS/MS Method Development and Validation for the Estimation of Lasmiditan in Bulk and Pharmaceutical Formulation ITM UNIVERSITY, GWALIOR #Acetonitrile #Formicacid #Lasmiditan #LC_MS_MS #chemistry #biochemistry #nanomaterial #analyticalchemistry #chemicalengineering #Phytochemicals #ChemicalSciences #ChemicalTechnology

𝗔 𝗺𝗼𝗱𝗶𝗳𝗶𝗲𝗱 𝗺𝗲𝗰𝗵𝗮𝗻𝗶𝘀𝘁𝗶𝗰 𝗮𝗽𝗽𝗿𝗼𝗮𝗰𝗵 𝗳𝗼𝗿 𝗽𝗿𝗲𝗱𝗶𝗰𝘁𝗶𝗻𝗴 𝗿𝗶𝗯𝗯𝗼𝗻 𝘀𝗼𝗹𝗶𝗱 𝗳𝗿𝗮𝗰𝘁𝗶𝗼𝗻 𝗮𝘁 𝗱𝗶𝗳𝗳𝗲𝗿𝗲𝗻𝘁 𝗿𝗼𝗹𝗹𝗲𝗿 𝗰𝗼𝗺𝗽𝗮𝗰𝘁𝗶𝗼𝗻 𝘀𝗽𝗲𝗲𝗱𝘀 This research investigates the modeling of the pharmaceutical roller compaction process, focusing on the application of the Johanson model and the impact of varying roll speeds from 1 to 15 RPM on predictive accuracy of ribbon solid fraction. The classical Johanson’s model was integrated with a dwell time parameter leading to an expression of a floating correction factor as a function of roll speed. Through systematic analysis of the effect of different roll speeds on the solid fraction of ribbons composed of microcrystalline cellulose, lactose, and their blends, corrective adjustment to the Johanson model was found to depend on both roll speed and formulation composition. Interestingly, the correction factor demonstrated excellent correlation with the blend’s mechanical properties, namely yield stress (Py) and elastic modulus (E0), representative of the deformability of the powder. Validated by a multicomponent drug formulation with ±0.6–1.6% differences, the findings underscore the utility of this modified mechanistic approach for precise prediction of ribbon solid fraction when Py or E0 is known for a given blend. Hence, this work advances the field by offering early insights for more accurate and controllable roller compaction operations during late-stage pharmaceutical manufacturing. Continue here: https://lnkd.in/ejYEipju Publication by Jingzhe Li, Yin-Chao Tseng, Shubhajit Paul #excipients #rollercompaction IFF JRS PHARMA MEGGLE Excipients BASF Pharma Solutions

Single Use Assemblies Market: Major Revenue Growth is Predicted in the Near Future Download FREE PDF Brochure to Find More Details@ https://lnkd.in/gGzJr3dx The market for single-use assemblies is expected to grow due in large part to the growing number of startups and SMEs using these assemblies, their quick implementation and low risk of cross-contamination, the expanding markets for #biologics and #biosimilars, the cost savings associated with using them, and technological advancements in single-use assemblies. However, the main obstacles impeding the growth of this market are challenges with leakage and integrity, regulatory concerns about single-use assemblies, and extractability and leachability with reference to disposable components. #pharma #pharmacerutical #pharmaceuticals #biopharma #pharmanews The single-use assemblies market is expected to develop at a compound annual growth rate (CAGR) of 15.6% from 2023 to 2028, from an anticipated $2.5 billion in revenue in 2023 to $5.2 billion in 2028. Leading Companies: Thermo Fisher Scientific Sartorius Danaher Corporation Merck KGaA, Darmstadt, Germany Avantor Saint-Gobain Repligen Corporation Corning Incorporated Entegris Meissner NewAge Industries, Inc. Antylia Scientific Lonza ROMYNOX SaniSure KEOFITT Dover Corporation Foxx Life Sciences TSE Industries among others.... Recent Developments of Single Use Assemblies Industry # In February 2022, Sartorius Stedim Biotech (France) acquired the chromatography division of Novasep (France). The portfolio acquired comprises #chromatography systems primarily suited for smaller #biomolecules. # In August 2022, Thermo Fisher Scientific opened a new single-use technology site in Tennessee, which has 400,000 square feet of floor space. It became the company’s largest SUT site in its growing network.

As a formulation development scientist you should have good understanding on below topics: 1. Polymorphism & solubility of API (https://lnkd.in/gWa73x5n...) 2. Biopharmaceutics Classification (https://lnkd.in/gDQzUtSM) 3. Choice of excipients (https://lnkd.in/ghVDWJWh) 4. API-Excipient compatibility study (https://lnkd.in/gdK3UtjZ) 5. RLD/RS characterization/Reverse engineering (https://lnkd.in/g_KJZQEz) 6. FDA dissolution method database (https://lnkd.in/gbrxCr3z) 7. FDA inactive ingredient database (https://lnkd.in/gYuZCUme) 8. Dissolution profile (https://lnkd.in/gdWRkbJb) 9. Stress/Force degradation study (https://lnkd.in/gH3ABkCy) 10. Stability study (https://lnkd.in/g8YiEspU) 11. Shelf- life Calculation (https://lnkd.in/gaD6HShs) 12. Impurites & Residual solvents (https://lnkd.in/gW9G7FC2 & https://lnkd.in/gY2JqYQq) 13. QbD tools & DoE (https://lnkd.in/gUs3ibAM & https://lnkd.in/gDwZRKah) 14. Process optimization and validation (https://lnkd.in/gQQBwFR8 & https://lnkd.in/gM-Ryq2h) 15. BE study and strategy (https://lnkd.in/gAHiky69) 16. SUPAC Guidance (https://lnkd.in/gykgDip7 & https://lnkd.in/g2Ky5RgB) 17. ANDA (https://lnkd.in/gJXbX7Pc) 18. Patent & Exclusivity (https://lnkd.in/gVq5mwJW) 19. 21 CFR Part 211 (https://lnkd.in/g__hRPjz) 20. Tablet problem & remedies (https://lnkd.in/gVNGWZzn)

As a formulation development scientist should have gone through the following: 1. Polymorphism & solubility of API (https://lnkd.in/gWa73x5n...) 2. Biopharmaceutics Classification (https://lnkd.in/gDQzUtSM) 3. Choice of excipients (https://lnkd.in/ghVDWJWh) 4. API-Excipient compatibility study (https://lnkd.in/gdK3UtjZ) 5. RLD/RS characterization/Reverse engineering (https://lnkd.in/g_KJZQEz) 6. FDA dissolution method database (https://lnkd.in/gbrxCr3z) 7. FDA inactive ingredient database (https://lnkd.in/gYuZCUme) 8. Dissolution profile (https://lnkd.in/gdWRkbJb) 9. Stress/Force degradation study (https://lnkd.in/gH3ABkCy) 10. Stability study (https://lnkd.in/g8YiEspU) 11. Shelf- life Calculation (https://lnkd.in/gaD6HShs) 12. Impurites & Residual solvents (https://lnkd.in/gW9G7FC2 & https://lnkd.in/gY2JqYQq) 13. QbD tools & DoE (https://lnkd.in/gUs3ibAM & https://lnkd.in/gDwZRKah) 14. Process optimization and validation (https://lnkd.in/gQQBwFR8 & https://lnkd.in/gM-Ryq2h) 15. BE study and strategy (https://lnkd.in/gAHiky69) 16. SUPAC Guidance (https://lnkd.in/gykgDip7 & https://lnkd.in/g2Ky5RgB) 17. ANDA (https://lnkd.in/gJXbX7Pc) 18. Patent & Exclusivity (https://lnkd.in/gVq5mwJW) 19. 21 CFR Part 211 (https://lnkd.in/g__hRPjz) 20. Tablet problem & remedies (https://lnkd.in/gVNGWZzn)

What´s today? Today and tomorrow (May 2 -3, 2024) the “6th Flow Chemistry and Continuous Processing Conference” organized by Scientific Update Ltd takes place in Boston USA. Our contribution on site is the "Semi-Batch and Scalable Continuous Synthesis of Grignard Reagents" with our recently graduated colleague Eva Deitmann.   About 10 percent of the 50 most important active pharmaceutical ingredients have one or more Grignard reactions in their synthesis pathway. Eva Deitmann will focus on industrially relevant research in the field of reactive intermediates and present our scalable, flexible and patented technology in Boston, which uses a permanent magnesium excess and microstructured reactors to synthesize the reactive intermediates reliably and in better quality.   Information about the conference 👉 https://lnkd.in/ePspr8GZ   Information about our industrial relevant research and development in the reactive intermediates 👉 https://lnkd.in/eFwkS6-7   #flowchemistry | #chemistry | #Fraunhofer | #research | #reactiveintermediates | #synthesis | #organicchemistry | #organometallics

Please feel free to look at this webinar where Prof. Daryl Williams talks about partical cohesion/adhesion and wettability of powders and formulations. Interesting stuff for Food technology and/or Pharmaceutical development, but the technique can be used in Coatings/Biomaterials! #particlescience #foodtechnology #formulation #coatings #biomaterials

Amorphous Solid Dispersion -- An Ideal Formulation Approach to Improve Developability of Poorly Soluble Molecules, Upcoming Webinar Hosted by Xtalks — MediaContacts.co — #pin this #free #webinar #learn how amorphous #solid dispersion revolutionizes #drug solubility, addressing aqueous solubility #challenges for enhanced bioavailability and pharmaceutical #development Attendees will #understand how amorphous solid dispersion differs from #traditional methods, enhancing bioavailability across various #drugs Attendees will #explore how amorphous solid dispersion improves drug solubility upon dissolution, boosting dissolution #rates The #featured #speaker will discuss amorphous solid dispersion applications for #poorly soluble drugs, supported by #case #studies and comprehensive #solutions from #screening to #GMP supplies. TORONTO, #Jan #4 #2024 #Discover an informative webinar uncovering the transformative impact of amorphous solid dispersion on drug solubility. Aqueous solubility results in low bioavailability and developability issues. Various approaches such as salt formation, solubilization using a co-solvent, complexation with cyclodextrin and particle size reduction have limitations for their wide applicability for all molecules. Amorphous solid dispersion is one of the most promising approaches that not only helps overcome the limitations of these other approaches but also helps enhance the bioavailability and enable compounds to toxicity studies. The solid dispersion approach has unique advantages in terms of its applicability for a wide range of molecules, safety of vehicles and scalability. The solid dispersion approach has unique advantages in terms of its applicability for a wide range of molecules, safety of vehicles and scalability. Solid dispersion refers to the dispersion of one or more active ingredients in a hydrophilic inert carrier matrix at the molecular level. It is prepared by the melt