Lucas Meyer Cosmetics - by Clariant’s Post

🚨 NEW INGREDIENT DROP 🚨 And it's one of my favorite kinds of ingredients - a new biomimetic peptide! If you'd like to address pro-aging skin concerns in a new, interesting way, then check out LMC's newest launch, Progeline FF, which helps delay senescence aka cell aging ⏰ Fun fact - Progeline FF is vegan, China compliant, and produced using a new green chemistry peptide synthesis process. Comment below/DM me if you'd like samples and more information. #peptides #beauty #personalcare #ingredients #theingredientsguy #cosmetics #cosmeticchemistry #sustainability #proaging #antiaging

🚨 Is Gen X the forgotten generation in beauty?   Not anymore! Meet Progeline™ FF, a groundbreaking biomimetic peptide designed to target aging at the cellular level. Crafted through a PFAS-free and green chemistry-based process, Progeline™ FF enhances cellular resilience and delays cell senescence, resulting in firmer, lifted and redesigned V-shaped face.   Ready to discover how to unlock your cellular beauty?   Learn more in the links below 👇   #GenX #CellularBeauty #Longevity #GreenerSynthesis

Aging-related muscle wasting is linked to changes in RNA processing, specifically alternative polyadenylation (APA) at the 3'-UTR of transcripts. The nuclear RNA binding protein PABPN1, known to suppress APA, experiences reduced levels during aging. In Oculopharyngeal Muscular Dystrophy (OPMD), caused by an expanded PABPN1, APA-shift is observed in muscle transcripts. However, this shift seems associated with decreased PABN1 levels rather than presence of the expanded protein.Muscle weakness in OPMD may result from a loss of PABPN1 function, leading to APA-shift in muscle-related transcripts. For further reading, click: https://lnkd.in/gEEy2mCF

Peroxisome proliferator-activated receptor gamma coactivator 1 (PGC-1) is a family of transcriptional coactivators that play a crucial role in regulating cellular energy metabolism, particularly in mitochondrial biogenesis and oxidative metabolism. The most studied member of this family is PGC-1α, which is primarily expressed in tissues with high energy demands, such as the heart, skeletal muscle, and brain (Zhang et al., 2023). PGC-1α functions by coactivating various transcription factors, including nuclear respiratory factors (NRF-1 and NRF-2), which are essential for the transcription of genes involved in mitochondrial function and biogenesis (Gleyzer et al., 2005; Read more:

APP C-terminal domain under-appreciated in the pathogenesis of Alzheimer's Disease ? (Continuation of my earlier post.) Updated schematics of https://lnkd.in/e4zX2_zv also highlighting triple neuronal injury mechanism (excitotoxicity enhanced; nuclear reprogramming toward pro-neurodegeneration; diminished energy supply via mitochondrial malfunction) of the C-terminus of APP, the parent protein of A-beta peptides which ultimately form aggregated amyloid.

Enhancing extracellular vesicle cargo loading by modulating the microRNA biogenesis pathway: in their latest article, Alex Eli Pottash, Steven Jay at the University of Maryland and collaborators hypothesised that miRNA loading into EVs could be enhanced by reducing competing interactions during the miRNA biogenesis process. Using miR-146a-5p as a model, they tested the effects of modulating transcription, nuclear export, and enzymatic cleavage steps on EV miRNA loading efficiency https://lnkd.in/eBD9UDaH Using HEK293T cells, they demonstrated that various modifications in the EV biogenesis pathway affected miRNA localisation to EVs. An article co-authored by Daniel Levy, Emily Powsner, Nick Pirolli, Leo K., Talia Solomon, Raith Nowak, Jacob Wang and Stephanie Kronstadt #extracellularvesicles #exosomes #therapeutics #fluorescence #Vesiculab

Yesterday, having joined us from The University of Texas Health Science Center at Houston (UTHealth Houston), Dr. Kang Ho Kim shared with us the fascinating journey of his research through nuclear receptors, bile acids, and more! He discussed nuclear receptors #CAR and #PXR displaying hepatoprotection, later transitioning to the relationship between cholic acid and ORM2 lending to an anti-#obesity phenotype and communication with #adipose tissue. Great stories, Dr. Kim! #hepatology #metabolites #metabolomics #NIDDK #DDRCC #TMC #DDC #obesity #BileAcids

💡 CRIG 'young investigator proof-of-concept projects’: Dorien Clarisse of the De Bosscher lab is one of the laureates of the 15th call! 👏 Congrats to Dr. Dorien Clarisse, who is delving into the complex interplay of nuclear receptors in multiple myeloma cells. Dorien explores the efficacy of bivalent ligands targeting the glucocorticoid receptor (GR) and mineralocorticoid receptor (MR) heterodimers. Promising advancements in overcoming therapy resistance and side effects associated with long-term glucocorticoid treatment in myeloma are on the horizon. Stay tuned for insights into the molecular mechanisms driving enhanced anti-myeloma potency and the potential of these novel ligands compared to conventional therapies. #MultipleMyeloma #MedicalResearch #NuclearReceptors

According to a new market research report published by Global Market Estimates, the global medical radioisotopes market is projected to grow at a CAGR of 4.8% from 2024 to 2029. The primary factors propelling the market growth are the increasing use of nuclear medicine imaging agents in diagnostic procedures and the rising adoption of radioisotope therapy. Browse 147 Market Data Tables and 115 Figures spread through 163 Pages and in-depth TOC on “Global Medical Radioisotopes Market - Forecast to 2029’’ https://lnkd.in/dgGmfx7K #GlobalMedicalRadioisotopesMarket #GlobalMarketEstimates #GME

From their abstract: Ferroptosis, a distinctive form of programmed cell death, has been implicated in numerous pathological conditions, and its inhibition is considered a promising therapeutic strategy. Currently, there is a scarcity of efficient antagonists for directly regulating intracellular ferrous iron. Ferritinophagy, an essential process for supplying intracellular labile iron, relies on nuclear receptor coactivator 4 (NCOA4), a selective autophagy receptor for the ferritin iron storage complex, thus playing a pivotal role in ferritinophagy. In this study, we reported a novel von Hippel–Lindau-based NCOA4 degrader, V3, as a potent ferroptosis inhibitor with an intracellular ferrous iron inhibition mechanism.