Lupus Research Alliance ’s Post

🔬🌐 Hugues Contamin, CEO of CYNBIOSE, and Erwan Bezard, CEO of Motac Neuroscience Ltd, recently contributed to an article featured in the journal Le Monde, emphasizing the geostrategic importance of access to primates for scientific and medical research. In this interview, Hugues Contamin and Erwan Bezard share a common vision regarding the need to establish a national strategy promoting access to this resource essential for European scientific sovereignty.  Without such strategy, research companies like CYNBIOSE and Motac Neuroscience Ltd have secured their long-term supplies through direct agreements with breeding centers. This enables them to offer a unique preclinical service for the asessment of biodistribution, efficacy and toxicity of innovative therapies targeting the #CNS, especially #genetherapies and #ASOs. You can find the full article here 👉 https://bit.ly/49bKat1

I am delighted to announce the publication of my first research article. 🎉 Our paper, published in Biological Research (Q1), explores the protective effects of certain Tacrine derivatives on liver cells, offering new insights into liver fibrosis treatment. In this study, we successfully transformed a known hepatotoxic agent into a hepatoprotective one, shedding light on the role of autophagy in liver fibrosis. A special thanks to the Science, Technology & Innovation Funding Authority - STDF and the Egyptian Knowledge Bank for their support, enabling us to publish this article in an open-access journal under their agreement with Springer Nature Group. For an in-depth look at our findings, you can read the full paper here: https://lnkd.in/dwMVPHwd

Looking to incorporate intestinal #organoids into your research? For our new E-book ▶ https://bit.ly/3UDYvdC we’ve curated our established protocols to help you get started, from isolating tissue and establishing organoid culture, through to more advanced assays such as toxicity testing and gene editing. #organoids #intestinalorganoids #organoidculture #toxicitytesting #drugtoxicity

Call for Papers It is with great pleasure that we extend our warmest welcome to the Advances in Molecular Diagnostics and Precision. Scheduled on [August 12–13], 2024 in Rome, Italy (HYBRID EVENT) By registering early, you can be sure of a spot saved for you. Website: [https://lnkd.in/g8J5j37k] 3rd Round Abstract Submission Ends: July 05th, 2024 Mid-Term Registration Ends: 30th May, 2024 We invite scholars, researchers, and practitioners to submit abstracts for paper presentations, panel discussions, and interactive workshops. Submissions should address one or more of the conference tracks and engage with innovative approaches, theoretical frameworks, and empirical findings in Molecular Diagnostics and Precision Medicine. #rome #italy #events #molecularbiology #moleculardiagnostics #proteomics #dna #rna #rnatherapeutics #mutations #microfluidics #genetictesting #genomics #genomicmedicine #pcr #pharmacogenetics #protein #genetics #precisionmedicine #pharmacogenomics #artificialintelligence #clinicaltrials #researchers #therapeutics #pathology #biomedical #mdx #bioinformatics #massspectrometry #nutrigenomics #pcr #mutation #pathogens #biomedicalresearch #digitalpathology #sciinovgroup #MDPM2024

Call for Papers It is with great pleasure that we extend our warmest welcome to the Advances in Molecular Diagnostics and Precision. Scheduled on [August 12–13], 2024 in Rome, Italy (HYBRID EVENT) By registering early, you can be sure of a spot saved for you. Website: [https://lnkd.in/g8J5j37k] 2nd Round Abstract Submission Ends: May10th 2024  Mid-Term Registration Ends: April 25th, 2024 We invite scholars, researchers, and practitioners to submit abstracts for paper presentations, panel discussions, and interactive workshops. Submissions should address one or more of the conference tracks and engage with innovative approaches, theoretical frameworks, and empirical findings in Molecular Diagnostics and Precision Medicine. #rome #italy #events #molecularbiology #moleculardiagnostics #proteomics #dna #rna #rnatherapeutics #mutations #microfluidics #genetictesting #genomics #genomicmedicine #pcr #pharmacogenetics #protein #genetics #precisionmedicine #pharmacogenomics #artificialintelligence #clinicaltrials #researchers #therapeutics #pathology #biomedical #mdx #bioinformatics #massspectrometry #nutrigenomics #pcr #mutation #pathogens #biomedicalresearch #digitalpathology #sciinovgroup #MDPM2024

News from BGV (BioGeneration Ventures) portfolio company, AZAFAROS B.V. Azafaros prepares to unveil data from the PRONTO study at the 20th annual WORLDSymposium™, focusing on GM1 and GM2 gangliosidoses. With four posters showcasing baseline data from the natural history study, Azafaros is shedding light on the intricacies of these rare diseases. The company is set to reveal the study design for the Phase 2 RAINBOW study, exploring the potential of their lead product, nizubaglustat, in patients with GM2 gangliosidosis and Niemann-Pick disease type C (NPC). Additionally, the results of the Phase 1 first-in-human study, examining the safety of nizubaglustat in healthy volunteers, have been recently published in the prestigious Molecular Genetics and Metabolism journal. Read more by clicking the link below. #Azafaros #RareDiseases #WORLDSymposium #MedicalInnovation #BGVPortfolioCompany #lifesciences #biotech

Einstein Image: Hepatocytes Hepatocytes—the predominant cell type in the liver—are polarized epithelial cells: Their basolateral domains face blood vessels and absorb substances from the blood, while their apical domains form the linings of the bile canalicular network—the tiny channels into which hepatocytes secrete bile, a detergent-like substance that breaks down fats in the small intestine. Francisco Lazaro-Dieguez, Ph.D., staff scientist in the laboratory of Anne Muesch, Ph.D., studies the molecular mechanisms involved in maintaining the bile canaliculi; the maintenance of these channels is compromised in important liver diseases including non-alcoholic fatty liver disease and hepatitis. Dr. Lazaro-Dieguez made this image, which shows isolated rat hepatocytes manipulated to form canalicular networks similar to those in vivo. Hepatocyte nuclei are shown in green. To visualize the bile canaliculi, the tight-junction protein zonula occludens-1 (yellow) and actin filaments (red) were stained. The multiprotein tight junctions help keep hepatocytes polarized by forming barriers separating their apical and basolateral domains. The image was one of the winners of the photo contest sponsored by ibidi, a biotechnology company, and is the March “Image of the Month” in the 2024 ibidi calendar. Dr. Muesch is a professor of developmental & molecular biology at Einstein. #molecularbiology #hepatocytes #epithelialcells #liver #research #science #imaging #biomedicalresearch

FRANCOISE BETTENCOURT MEYERS L'OREAL HEIRESS c/o: ODEON RESTAURANT & CAFE. TRIBECA NY WHAT'S ON THE TABLE UPSTAIRS.? I HOPE A NY HAMPTON BEACH HOUSE.! LATE JOSE' CHEF & LOUIE BILL & MELINDA GATES FOUNDATION GATESFOUNDATION.org TENRI CULTURAL INSTITUTE tenri.org https://lnkd.in/e55sRd8b https://lnkd.in/eB98Jnv9 WonderMind.com: CRYPTO-FINANCE & REYGITONIUM-G MR. MS. TEEFEY & SELENA GOMEZ-RARE-SUPERSTAR. TCI GALLERY SPRING 2024 THEMES. CRYPTOCURRENCY & REYGITONIUM-G TO WHOM IT MAY CONCERN: I ABSOLUTELY SEE NOTHING WRONG WITH CRYPTOCURRENCY: REYGITONIUM-G I CAN UNDERSTAND WHY THE INFANT DEMOCRATIC-CAPITALISTIC MINDS OF TODAY BLAME USA GOVERNMENT. THEN IS ANY GOVERNMENT TO BE BLAMED FOR HOMELESS PROBLEMS PLAGUING THE WORLD.? NO. GOD KNOWS HEADACHES USA GOVERNMENT HAVE WITH THE FOREIGN AFFAIRS. THE NEW WORLD PRACTICALLY SHOCK TO WITNESS. PEOPLE ONLY WORKING TOGETHER FOR A COMMON GOAL. "IN THE PURSUIT OF HAPPINESS." DOESN'T THAT ALSO INCLUDE THE HOMELESS. THE HOMELESS ARE OUT THERE. ARE YOU.? HOMELESS.. OPPORTUNITY MISUNDERSTOOD. The modern economic system is a market economy, which is a capitalist economy where people, not the government--NOT THE GOVERNMENT--own most businesses. In a capitalist economy, prices allocate capital and labor between competing uses, and capital assets can be privately owned and controlled. https://lnkd.in/eB98Jnv9 EXAMPLE, IF YOU NEED TO RAISE MONEY FOR ANY REASON OR MORE SO LETS SAY THE "HOMELESS" PROBLEM WHICH IS BELIEVED TO BE TIME & MONEY CONSUMING BUT IN ONE DIRECTION TOWARD THE HOMELESS. HOWEVER CRYPTOCURRENCY CAN POSSIBLE ALLOWS AN EXPENDITURE OF CURRENCY TO BENEFIT ALL WHO USES THE CRYPTO & REGARDLESS OF HOW IT'S CONSUMED. THEREFORE IF A CRYPTO HOMELESS CURRENCY REYGITONIUM-G EXISTED IT'S MORE HIGHLY LIKELY THAT THE HOMELESS PROBLEM CAN BE VANQUISHED BECAUSE CURRENCY-FINANCES IT'S ALWAYS AVAILABLE TO BE TAPPED INTO FOR HOMELESS RESOLUTIONS. REYGITONIUM-G: EACH COUNTRY GOVERNMENT INITIAL $1-DOLLAR INVESTMENT PORTFOLIO OF 8-BILLION EARTH CITIZENS. THEREAFTER GLOBALLY ANYBODY CAN INVEST IN THE CRYPTOCURRENCY REYGITONIUM-G. OR CONTINUE HIDING THE HOMELESS WHEN A POLITICAL LEADER VISITS AMERICA. CLOSING COMMENT: THE DAMNEDEST CRAZIEST FUNNIEST EMBARRASSING ABOUT THE HOMELESS CHAOS IS ANY EXCUSE AS TO WHY HOMELESS EXIST. HENCEFORTH CONSIDER USA TRILLIONS IN DEBT & 6,120 HOSPITALS SCATTERED AROUND THE USA & MANY COUNTRIES ASKING FOR FOREIGN AID IN THE TRILLIONS & YOU TALKING EXCUSES. MEANWHILE WE WANT TO SETTLE HUMANITY ON OTHER PLANETS. THANK YOU FOR READING.

{فَأَمَّا الزَّبَدُ فَيَذْهَبُ جُفَاءً ۖ وَأَمَّا مَا يَنفَعُ النَّاسَ فَيَمْكُثُ فِي الْأَرْضِ} Alhamdulillah always forever ♥️ I'm thrilled to share that our scientific book " Epinephrine : uses, Mechanism of action, and Adverse effects" has been published and I am honored to be one of the authors for two chapters. This book is the result of a great effort of research. In this book, we collected a lot of important information about epinephrine, its uses, its mechanism of action, and its potential harmful effects, such as suppressing the immune system and its relationship to Cancer and others . If you are interested in the field this book will be a good and valuable source for you. #epinephrine #biology #biochemistry #mechanismofaction #immunesystem #scientificbook #Healthcare #medicalbooks #MedicalResearch

Meet Dr. Pamela Moll, our Head of Kit Development at Lexogen, as part of this series where we delve into the scientific journeys of our team members! "I studied in Salzburg and worked on Vitamin D's effects on primary human keratinocytes, crucial for psoriasis. Vitamin D treatment showed promise then, leading me to explore differential gene expression. After earning my doctorate, I spent four years in Toronto focusing on nucleo-hormone receptors, working on establishing transgenic zebrafish lines for all 48 human nucleo-hormone receptors. The goals? Isolating the ligands for the so-called orphan receptors and track the activity of the different receptors during development in transgenic lines, like a lightbulb illuminating activity in tissues. "After Toronto, I decided to return to Austria. Then, I stumbled upon a job ad for Lexogen—a perfect fit for my CV. Three days after the interview, they offered me a position. Starting as a Research Scientist, I now lead Kit Development. As a Head of Kit Development - you have a goal in sight - and you want to develop reproducible, efficient and convenient tools to help other scientist reach their scientific goals. Our R&D team is incredible—they tackle all my odd requests with enthusiasm. With each project, we draw from the wealth of experience behind us. All of the experiments that you ever did - they leave an impact on you.” Curious to learn more about incredible women behind Lexogen? Check out our latest blog post and be inspired: -> https://lnkd.in/dGWNhGRs🔬 #WomenInScience #TeamLexogen