This paper presents an improved anion exchange analytical method . It delivers enhanced separation of full AAV capsids from other common product-related impurities such as aggregates, and empty, partially filled, high density, or damaged capsids. The improved anion exchange analytical method has been shown to be applicable for different AAV serotypes.
The improved AEX analytical method delivers enhanced separation of not only empty and full AAV capsids, but also other impurities, such as partially filled and heavy capsids, and aggregates. Just published in: Cell & Gene Therapy Insights 2024; 10(3), 503–511 DOI: 10.18609/cgti.2024.063