Focused to identify, develop and launch innovative solutions for severe medical conditions. ***posts, views and opinions are personal and are not related to my past and current employers, partners and clients***
Bellinzona & Bethesda - I am excited and honored to share and co-authour Profs. Paolo Paganetti and Maurizio Molinari labs’ new data published in Nature Scientific Reports (https://lnkd.in/eqWbSvvV), where a novel mechanism linking glucocerebrosidase (GCase), lysosomal dysfunction and Tau accumulation has been shown. The findings continue to support the need for new disease-modifying therapeutic approaches to address lysosomal dysfunction and GCase and for Parkinsons and other neurodegenerative conditions. This work has been partially financed by Innosuisse – Swiss Innovation Agency in collaboration with Gain Therapeutics. #allostery #lysosomes #clinicalresearch #drugdevelopment #drugdiscovery #neurodegeneration #ParkinsonsDisease #tau #autophagy #innosuisse #ganx #gaintherapeutics #stars #irb #eoc #bethesda #bellinzona #ticino
We’re excited to announce new data from our collaborators at the Institute for Research in Biomedicine and the NeuroCenter of Southern Switzerland of EOC. In a paper published in Nature Scientific Reports (https://lnkd.in/g-cXyyXN), the researchers showed novel mechanisms linking glucocerebrosidase (GCase) dysfunction, lysosomal dysfunction and Tau accumulation to neurodegenerative diseases. The findings provide further scientific validation of therapeutic approaches that address GCase and lysosomal dysfunction for Parkinson’s and other neurodegenerative conditions. At Gain, we’re tackling GCase and lysosomal dysfunction in neurodegenerative diseases with our clinical-stage candidate GT-02287, a novel GCase-targeting small molecule with disease-modifying potential for the treatment of GBA1 Parkinson’s disease. Learn more at https://lnkd.in/gB_FempR The research project has been partially financed by Innosuisse – Swiss Innovation Agency in collaboration with Gain Therapeutics. Authors: Piovesan et al. #allostery #lysosomes #clinicalresearch #drugdevelopment #drugdiscovery #neurodegeneration #ParkinsonsDisease #tau #autophagy #innosuisse
Life science Consultant / R&D Manager / Drug Discovery / C-level roles / Small molecules development / Biochemist / Cancer researcher
1yImpressed by the enormous potential of the newly published findings and by the fruitful collaboration between academic researchers and Pharma.