Manuele Rebsamen’s Post

In a fun collaboration with @Deepakarao, from Brigham and Women's, my superstar PhD student Calvin Law (with Vanessa and Cyan from the Rao lab) discovered mechanisms underlying CXCL13 production specifically and more broadly B-helper T cell differentiation in lupus. interestingly, one form of B-helper T cells, T peripheral helper cells, and Th22 cells exist on an epistatic axis. Tph cells are higher in the blood of lupus patients; CD96+ Th22 patients are lower. This axis is controlled by relative amounts of AHR and type I interferon and can be pharmacologically changed by blocking type I interferon or adding AHR agonists. Potentially an exciting "new" approach to treating antibody-driven autoimmune diseases. https://lnkd.in/g8xKbfwE

#NASH and #NAFLD are difficult to diagnose and treat…and these diseases are on the rise. In this paper out this week in Nature Scientific Reports, the SomaScan® Assay and SomaSignal™ tests were a powerful #proteomics duo in a clinical trial to test the effectiveness of clesacostat, a new drug aimed at treating these liver diseases. Read the paper here: https://lnkd.in/gG3n37CB

Check out the SomaScan platform with the SomaSignal Test models to predict >20 disease areas. #biomarkers #proteomics #drugdevelopment SomaLogic

#NASH and #NAFLD are difficult to diagnose and treat…and these diseases are on the rise. In this paper out this week in Nature Scientific Reports, the SomaScan® Assay and SomaSignal™ tests were a powerful #proteomics duo in a clinical trial to test the effectiveness of clesacostat, a new drug aimed at treating these liver diseases. Read the paper here: https://lnkd.in/gG3n37CB

#NASH and #NAFLD are difficult to diagnose and treat…and these diseases are on the rise. In this new paper in Nature Scientific Reports, the SomaScan® Assay and SomaSignal™ tests were a powerful #proteomics duo in a clinical trial to test the effectiveness of clesacostat, a new drug aimed at treating these liver diseases. Read the paper here: https://lnkd.in/gG3n37CB

NANOTALKS IS COMING!!!] Eps. #58 Hepatitis B virus infection continues to be a global health problem, affecting millions of people worldwide. Research efforts have been focused on developing new antiviral agents to combat hepatitis B virus infection. Emodin, a natural compound found in certain plants, has shown potential as an HBV replication inhibitor. By modifying specific functional groups of the emodin molecule, it can enhance its potency and selectivity towards HBV replication. Wondering how to Design and Synthesis of Emodin Derivatives as HBV Replication Inhibitors? Let's answer your curiosity at Nanotalks Eps. #58: Design and Synthesis of Emodin Derivatives as HBV Replication Inhibitors, with inspirational speaker and expert in the field of medicinal chemistry, Dr. Firdayani, M.Farm. The webinar will be held on: 📅 Thursday, April 25th 2024 ⏰16.00 - 17.30 WIB (UTC +7) via Zoom Virtual Meeting. There will be door prizes in the form of books on 300 nano scientists and discount vouchers for nano services for the lucky ones!! 🤑 Registration link: bit.ly/nanowebinar58 More info: 📧 research@nano.or.id

[NANOTALKS IS COMING!!!] Eps. #58 Hepatitis B virus infection continues to be a global health problem, affecting millions of people worldwide. Research efforts have been focused on developing new antiviral agents to combat hepatitis B virus infection. Emodin, a natural compound found in certain plants, has shown potential as an HBV replication inhibitor. By modifying specific functional groups of the emodin molecule, it can enhance its potency and selectivity towards HBV replication. Wondering how to Design and Synthesis of Emodin Derivatives as HBV Replication Inhibitors? Let's answer your curiosity at Nanotalks Eps. #58: Design and Synthesis of Emodin Derivatives as HBV Replication Inhibitors, with inspirational speaker and expert in the field of medicinal chemistry, Dr. Firdayani, M.Farm. The webinar will be held on: 📅 Friday, April 25th 2024 ⏰16.00 - 17.30 WIB (UTC +7) via Zoom Virtual Meeting. There will be door prizes in the form of books on 300 nano scientists and discount vouchers for nano services for the lucky ones!! 🤑 Registration link: bit.ly/nanowebinar58 More info: 📧 research@nano.or.id

Drug-induced skin swelling . Angioedema is a rare but potentially life-threatening adverse reaction to ACE inhibitors. Researchers have now conducted a genome-wide association study (GWAS) with more than 1,000 affected individuals. They identified a total of three risk loci in the genome. These included a new locus that had not previously been associated with the risk of ACE inhibitor-induced angioedema. #ScienceDailynews #InnovativeResearch #NextGenScience #ExploringFrontiers

The following publication could be a breakthrough in drug discovery field concerning autoimmune and inflammatory diseases. Scripps Research scientists present the structures of two nucleic acid-degrading enzymes—PLD3 and PLD4. Understanding these enzymes’ 3D structures is an important step towards designing therapies for lupus erythematosus, rheumatoid arthritis and Alzheimer’s’ disease. These enzymes are important for cleaning up the cellular environment, and they also set the threshold for what is considered an infection or not. PLD3 and PLD4, breakdown RNA or DNA into nucleotides. The structural analyses revealed that PLD3 and PLD4 are structurally similar and that they degrade nucleic acids via a two-step process. Exploring possible ways of inhibiting the enzymes’ hyperactivity may provide novel therapeutics for autoimmune diseases. #autoimmune #drugdiscovery #medicinalchemistry #pharmaceuticalchemistry #scripps

Please read our newest study where we showed that Fisetin mitigates DSS-induced colitis by targeting senescence and inflammation and restoring beneficial bacteria in the gut - potential potential nivel therapeutic intervention for IBDs. https://lnkd.in/eUj4jqkU