Martin Schaier’s Post

Systematic benchmarking of imaging spatial transcriptomics platforms in FFPE tissues https://lnkd.in/e_cbsmW6

In order to generate a highly multimodal imaging dataset, a group of researchers from The Jackson Laboratory share a protocol to prepare tissue slides for multiplexed imaging on the Phenocycler-Fusion platform and H&E staining following a Xenium run. See the link to the step-by-step guide 👇

Check out my interview with SelectScience® in case you missed the opportunity to stop by Nanolive's booth or Tech Talk at the ELRIG UK Drug Discovery Conference. I explain how Nanolive SA's unique imaging & analysis technology works, and how it can be used for novel drug discovery insights, in under 5 mins. #livecellimaging #drugdiscovery #metabolism #cellbiology

📍 Integration of mass cytometry and mass spectrometry imaging for spatially resolved single-cell metabolic profiling Nunes et al. developed a novel multimodal mass spectrometry imaging approach for the integrated analysis of metabolites and immunophenotypes in human tissues.   Key points 📌 Integrating matrix-assisted laser desorption/ionization-mass spectrometry imaging (MALDI-MSI) and imaging mass cytometry (IMC) 📌 A wet-lab protocol allowing the application of both technologies on the same tissue section 📌 A data integration strategy enabling the relative quantification of metabolites (measured by MALDI-MSI) at the single-cell level (defined by IMC). ➡ More details: https://lnkd.in/emuRX48j #LeidenUniversityMedicalCenter #spatialomics #spatialbiology #singlecellanalysis #singlecell

🥳#mdpitoxins Issue 7 is released! 43 interesting articles were published: https://lnkd.in/g9EyD4Dw The paper on the cover studied "Shining a Light on Venom-Peptide Receptors: #Venom Peptides as Targeted Agents for In Vivo Molecular Imaging". 📖 https://lnkd.in/gYzMkYK9

The Rutgers University Molecular Imaging Core (RUMIC) and the Advanced Preclinical Imaging Lab (APIL) are offering tours through the month April 2024. Each tour consists of a brief presentation, providing an overview of the use and capabilities of the Cores, followed by atwitter short demo for each imaging system. Examples of image processing and data analysis will be presented and the application of imaging technology to research will be discussed. Learn more ➡️ https://loom.ly/cHhyme4

Hey everyone, ever feel like spatial biology analysis is a guessing game? 🤔 Say goodbye to the "known target" hassle and hello to hypothesis-free fun with MicroscoopTM! Imagine targeting specific region of interest in your samples, letting MicroscoopTM do its magic for automated, image-guided proteomic adventures. 🌟 No biases, just pure discovery! It's a real #spatialproteomics. And the best part? We're not just talking about high resolution—we're talking individual cellular organelle-level detail! 😲 I'm also excited to share that I am one of the authors. Check out our application note to delve deeper into the details of our magical system.

💡 Application in the spotlight. In this study by Nock et al. of the Molecular Radiopharmacy Department of INRASTES, National Center for Scientific Research "Demokritos", preclinical SPECT-CT imaging is used to evaluate new anti-CCK2R theranostic agents. Total body SPECT-CT imaging was used as a non-invasive and quantitative screening tool to select candidates for further clinical evaluation.  🔗 Read more about this paper via the link in the comments!  #SPECT #PreclinicalImaging #Theranostics 

📢Our latest application note has just been released! Discover the power of precision with Microscoop™ – the forefront of image-guided proteomics! 🎯 Our platform is redefining protein isolation by zeroing in on specific regions within cells and tissue samples. No guesswork here – just robust, hypothesis-free protein identification powered by microscopic analysis. 🔬 With Microscoop™, experience the power of precise photo-biotinylation utilizing ultrafast femtosecond pulses for two-photon illumination, pinpointing targets at the scale of individual organelles. This technology opens doors to a detailed exploration of subcellular protein dynamics and relationships, providing critical insights into the intricate subcellular structures that drive biological discovery. Learn more about the broad application of Microscoop in our new #AppNote - https://lnkd.in/gtz6_q6B #Microscoop #Proteomics #ProteinDiscovery #LaserNanoPulldown #ScoopBiology

Unlock the potential of your cell proliferation research with ClickTech EdU cell proliferation advanced kits in flow cytometry, imaging, high throughput screening and microplate applications from baseclick. Achieve breakthrough results and accelerate your discoveries with confidence. Evaluate your science with precision and reliability. #cellbiologie #BrdU #DNA synthesis #flowcytometry #HTS #Imaging #Tcellproliferation https://lnkd.in/ezZTA3Y8