Massachusetts General Physicians Organization (MGPO)’s Post

Published in JAMA, July 3, 2024! Study links Ozempic to higher risk of eye condition that can cause vision loss! Risk of Nonarteritic Anterior Ischemic Optic Neuropathy in Patients Prescribed Semaglutide! 👉Conclusions and Relevance: 🧩This study’s findings suggest an association between semaglutide and NAION. 🧩As this was an observational study, future study is required to assess causality.

Research underway at Ontario's hospitals can help unlock the secrets of how treatments work and opportunities for advancement. Professor Daniel Drucker and his team at Sinai Health's Lunenfeld-Tanenbaum Research Institute have discovered a gut-brain-immune network that controls inflammation across the body and affects organ health. The research centres on the effects of glucagon-like peptide-1 (GLP-1) receptor agonists, or activators, which clinicians use to treat type 2 diabetes and which have recently proven highly effective for weight loss. “We know from clinical studies that GLP-1 does all this amazing stuff in people, but we don't fully know how it works," said Drucker. Drucker has received some of the world's most prestigious awards in the life sciences for his many findings on GLP-1, including the 2023 VinFuture Emerging Innovation Prize and the 2023 Wolf Prize in Medicine. As well, GLP-1-based diabetes drugs that emerged from Drucker's early research were named 2023 breakthrough of the year by the Science Magazine. Read more about this study: https://lnkd.in/g-sE6vVv #hospitalresearch #diabetes

#obesity #inflammation https://lnkd.in/gXArUWrf #Metaflammation in obesity and its therapeutic targeting Abstract Obesity-associated inflammation is a systemic process that affects all metabolic organs. Prominent among these is adipose tissue, where cells of the innate and adaptive immune system are markedly changed in obesity, implicating these cells in a range of processes linking immune memory to metabolic regulation. Furthermore, weight loss and weight cycling have unexpected effects on adipose tissue immune populations. Here, we review the current literature on the roles of various immune cells in lean and obese adipose tissue. Within this context, we discuss pharmacological and nonpharmacological approaches to obesity treatment and their impact on systemic inflammation.

📢 Review paper Sharing-Vol. 29 No. 6 💕 Title: Endothelial Cell Dysfunction: Onset, Progression, and Consequences 🤵 Authors: Hojjat Naderi-Meshkin,*, Wiwit Ananda Wahyu Setyaningsih 🔔 Full Text: https://lnkd.in/gj-pHsxp 🔑 Keywords: cardiovascular diseases metabolic disorders blood vessels disease modelling vascular dysfunction therapeutic interventions 😎Welcome to your reading! #Bioscience #biomedicalscience #biochem #medicalscience #ScienceCommunication #Biochemistry #StemCell #Virology #CancerResearch #immunology #Genetics #MolecularBiology #Microbiology #medicine #health #CellularHealth #CellCancer

https://lnkd.in/dRaUywRd PRECAME Study: Preventing cardiovascular effects with metformin in obese patients ( Corpori Sano Biotechnology & Walter LAB, Brasil 🇧🇷 2002 ): " Creating a scientific basis for an infinite possibility of future studies and research " " Specific therapy, to live healthily " " The era of insulin resistance modulators, ability to alter the cellular regulatory circuit " " A new therapeutic approach in cardiovascular, metabolic and oncological prevention " " Scientific research that studies the basis of the iceberg of cardiovascular disease " " Through innovative medicines for public health and committed to bringing better health and a better future for patients, translating science and regenerative medicine into medicines that change human lives, as the main objective " " PRECAME Study and Walter's Metabolic Theory, improving the perspective and quality of life of patients " #science #ciencia #health #innovation

🚨 New Review Alert! 🚨 Just published in Biomedicines MDPI📚✨ This article dives deep into the emerging role of Glucagon-like Peptide-1 Receptor Agonists in managing obesity-related heart failure with preserved ejection fraction (HFpEF) 💉💪❤️ https://lnkd.in/d8vinTkf A must-read for anyone interested in the latest advances in cardiovascular and metabolic health! 🌟 #MedicalResearch #CardioHealth #ObesityManagement #HFpEF

Researchers from City of Hope have made strides in predicting kidney failure in type 1 diabetes patients. Their study, recently published in Science Translational Medicine, represents a leap forward in early detection, prevention and progression of kidney disease in the vulnerable population. Rama Natarajan, Ph.D., deputy director of the Arthur Riggs Diabetes & Metabolism Research Institute at City of Hope and the National Business Products Industry Endowed Chair in Diabetes Research, and her team performed the first epigenome-wide association analysis in patients with diabetic kidney disease leading to the discovery novel associations between DNA methylation — a process that can alter the activity of a DNA segment — and the risk of developing kidney failure over time. Type 1 diabetes, affecting approximately 9 million people globally, is linked to a significantly increased risk of kidney disease, often progressing to kidney failure. As Dr. Natarajan emphasized, "It is critical to find mechanisms leading to kidney failure in diabetes, as well as biomarkers of early detection to facilitate prompt intervention." Read more: https://lnkd.in/ewheuiA9

Identifying circulating extracellular vesicle-carried PTP1B and PP2A phosphatases as key regulators of insulin resistance: in this article, Sakina Ali, M. Carmen Martínez at the University of Montpellier and collaborators explored how large and small EVs from insulin-resistant individuals could induce systemic, adipose tissue, and liver insulin resistance in healthy mice. Additionally, they examined the underlying mechanisms of EV-induced insulin resistance in cultured cells. https://lnkd.in/edfwKeYi Their data showed that blocking phosphatases in EVs from insulin-resistant individuals restores insulin signaling in adipocytes and hepatocytes, identifying EV-carried PTP1B and PP2A as promising therapeutic targets for combating insulin resistance in adipose tissue, liver, and obesity. An article co-authored by Xavier Vidal Gomez, Megan Piquet, Luisa Vergori, Gilles Simard, Séverine Dubois, Pierre-Henri Ducluzeau, Pascal Pomiès, Sarah Kamli-Salino, Mirela Delibegovic, PhD, FRSE, Samir Henni, Pr Frédéric Gagnadoux and Ramaroson Andriantsitohaina #extracellularvesicles #exosomes #insulin #adiposetissue #Vesiculab

post stroke cognitive recovery

🌟 Exciting Research Alert! 🌟 Did you know that microplastics and nanoplastics (MNPs) have been discovered in atheromas, the plaques in our carotid arteries, and are linked to cardiovascular events? 🫁🔬 Recent studies suggest that MNPs can trigger oxidative stress, inflammation, and cell death in our blood vessels, potentially affecting heart health and endothelial function. 🤯 Research on patients undergoing carotid endarterectomy revealed a significant association between the presence of MNPs in their plaque and a higher risk of heart attacks, strokes, or even death. 🚑💥 The detection of polyethylene and polyvinyl chloride in these plaques points to possible sources like food containers and water pipes. 🥤🛢️ These findings emphasize the urgent need for more research on the impact of plastics on both human health and the environment. 🌍🔍 For more details, check out the full article here: Microplastics and Nanoplastics in Atheromas and Cardiovascular Events - New England Journal of Medicine https://lnkd.in/eaUTbuJm. #Microplastics #Nanoplastics #CardiovascularHealth #ResearchUpdate #HealthAndEnvironmentAwareness 🌱🧠