In case you missed the news late last year, Tome Biosciences has been making waves in the biotech space with more than $200 million in investments from major VCs. While those numbers are impressive, what’s driving that interest is more exciting: the use of #CRISPR technology to insert new genes in a process called programmable genomic integration (PGI). This new approach modifies the CRISPR process – which up until now has been primarily used to edit existing genes – and combines it with enzymes that can insert entirely new genetic code into DNA. This could give doctors and scientists far more control over genetic therapies and open the door for new treatments and even cures for genetically driven diseases. The basis of the PGI research comes from this fascinating paper in Nature Biotechnology: https://lnkd.in/ekqRGnBn Figure 1 shows the schematic of the novel Cas fusion protein that is enabling this new technology. The team behind this work wrote a paper about it two years ago and I’m eager to see what the Tome team does with that foundation as they move towards a commercial launch. Perhaps #HPLC chromatography and #lcms mass spectrometry will play a role in characterizing and performing release testing on future drug substances and products. #LifeatWaters #WatersInnovation
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Pursuing Bsc Honours in Biotechnology | Final Year Student | Exploring the Frontiers of Biotech Innovation | Passionate about Innovating Healthcare | Biotech Enthusiast 🔬🧬
🔸𝘾𝙍𝙄𝙎𝙋𝙍-𝘾𝙖𝙨9 𝙏𝙚𝙘𝙝𝙣𝙤𝙡𝙤𝙜𝙮: ✳️CRISPR-Cas9 is a revolutionary gene-editing technology that allows precise modification of DNA in various organisms, including humans. CRISPR stands for Clustered Regularly Interspaced Short Palindromic Repeats, which are specific DNA sequences found in bacteria. Cas9, on the other hand, is an enzyme that acts like molecular scissors. ✳️The process begins by designing a synthetic RNA molecule, often called guide RNA (gRNA), which matches the target DNA sequence. This gRNA is then combined with the Cas9 enzyme to form a CRISPR-Cas9 complex. When introduced into a cell, this complex searches for the matching DNA sequence. Once found, Cas9 cuts the DNA at the targeted location. ✳️This cut triggers the cell's natural DNA repair mechanisms, leading to modifications such as gene insertions, deletions, or replacements. Scientists can harness this process to edit genes for various purposes, including studying gene function, treating genetic disorders, or creating genetically modified organisms. ✳️CRISPR-Cas9 has garnered widespread attention for its simplicity, efficiency, and versatility, making it a powerful tool in genetic research and potential therapeutic applications. However, ethical and safety considerations accompany its use, sparking ongoing discussions about responsible gene editing. Image source: https://pin.it/7qROk4p #biotechnology #biotechnologystudent #biotech #microbiology #biochemistry #science #research #sciencecommunity #lifescience #carrerinbiotech #futureofbiotech #geneediting #crisprcas9 #dikshitaramse
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Simple informative explanation for CRISPR-Cas9 technology
Pursuing Bsc Honours in Biotechnology | Final Year Student | Exploring the Frontiers of Biotech Innovation | Passionate about Innovating Healthcare | Biotech Enthusiast 🔬🧬
🔸𝘾𝙍𝙄𝙎𝙋𝙍-𝘾𝙖𝙨9 𝙏𝙚𝙘𝙝𝙣𝙤𝙡𝙤𝙜𝙮: ✳️CRISPR-Cas9 is a revolutionary gene-editing technology that allows precise modification of DNA in various organisms, including humans. CRISPR stands for Clustered Regularly Interspaced Short Palindromic Repeats, which are specific DNA sequences found in bacteria. Cas9, on the other hand, is an enzyme that acts like molecular scissors. ✳️The process begins by designing a synthetic RNA molecule, often called guide RNA (gRNA), which matches the target DNA sequence. This gRNA is then combined with the Cas9 enzyme to form a CRISPR-Cas9 complex. When introduced into a cell, this complex searches for the matching DNA sequence. Once found, Cas9 cuts the DNA at the targeted location. ✳️This cut triggers the cell's natural DNA repair mechanisms, leading to modifications such as gene insertions, deletions, or replacements. Scientists can harness this process to edit genes for various purposes, including studying gene function, treating genetic disorders, or creating genetically modified organisms. ✳️CRISPR-Cas9 has garnered widespread attention for its simplicity, efficiency, and versatility, making it a powerful tool in genetic research and potential therapeutic applications. However, ethical and safety considerations accompany its use, sparking ongoing discussions about responsible gene editing. Image source: https://pin.it/7qROk4p #biotechnology #biotechnologystudent #biotech #microbiology #biochemistry #science #research #sciencecommunity #lifescience #carrerinbiotech #futureofbiotech #geneediting #crisprcas9 #dikshitaramse
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Accelerate business growth through strategic LinkedIn advertising and Google advertising | Lead Generation Specialists
"Biotechnology continues to be a driving force in shaping the future of various industries, with a focus on innovation and sustainability. Recent trends in biotechnology include the rise of personalized medicine, gene editing technologies like CRISPR, and the development of bio-based materials for a more sustainable future. The integration of artificial intelligence and big data analytics is also revolutionizing the biotech industry, enabling faster drug discovery and more precise genetic engineering. As biotechnology continues to evolve, it is poised to address some of the most pressing challenges facing society today, from healthcare to environmental sustainability." #LinkedIn #Social #Biotechnology #Innovation #Success #Bioinformatics #Genes #CRISPR #Future
I make biological sciences approachable.
8moPGI can be a scary concept to an untrained individual. I like to approach the concept of genetic manipulation from the concept of a carrot. They used to be purple. Now they're orange. They taste the same.. Clustered regularly interspaced short palindromic repeats are no different. To me its just a big boy wording of "bacteria figured it out before us now we're trying to back-splain it."