Matthias Krumb’s Post

🔍💡 Step into the World of Drug Discovery with MolDrug! 🧪🔬 Ever wondered how promising compounds are chosen for further development? 🤔 It all starts with the hit to lead phase - a crucial step where potential winners emerge from vast compound libraries. 💊💥 At MolDrug, we're here to elevate this process with our range of services, including virtual screening, pharmacophore modeling, fragment-based screening, NMR-based interaction and screening, and QSAR bioactivity analysis. 🌟 Let's unlock the potential of your compounds together! #MolDrug #DrugDiscovery #HitToLead #PharmaInnovation #VirtualScreening #PharmacophoreModeling #NMR #QSAR 🚀🔬

Closing the loop on #macrocycles! This wonderful modality continues to evolve, defying the rules of permeability and pushing the boundaries of small molecule #drugdiscovery. From selective #PROTAC warheads, to exquisitely potent inhibitors, these marvellous molecules continue to surprise us with their versatility and properties. Tune into Gerhard Muller and learn about SpiroChem's macrocycle synthesis platform and the QUEST library possibilities! ✨

Unlocking the future of drug discovery! Harness the power of our in-house Cryo-EM at XralPi to revolutionize how you gather insights on target structures and facilitate drug discovery. Dive deeper into our capabilities by clicking the link below!

Alcami Corporation's Solid-State Characterization team has the expertise to design and execute crystal-form screening workflows and to comprehensively evaluate novel API forms. A solid-state study, including identification of new chiral modification of a long-known drug, guaifenesin, and detailed characterization and quantification were all part of a recent publication in “Crystal Growth and Design” titled: “Discovery, Characterization, and Solid-State Quantification of the Racemic Compound of Guaifenesin” Congratulations to Joanna Bis, Briana Graves, Frank Tarczynski, and Lukasz Wojtas on this publication! Read the article ➡️ https://gag.gl/oLTgQB #SolidStateCharacterization #Crystalformscreening #SolidStateQuantification #Discovery #casestudy #artinspiration #racemiccompound #smallmolecule #crystallization #CDMO #Alcami #research #APIscreening #published

Kicked off with discussions at the workshop day with topics including: 💡 Workshop A - Unveiling the Protein Universe: Structure-Based Drug Design with NMR, X-Ray Crystallography, & Cryo-EM 💡 Workshop B - Navigating Protein Samples for Each Structural Technique to Optimize Protein Production & Supercharge Structure Determination 💡 Workshop C - Diving Deep into Data: Cultivating Data Acquisition & Management for Structural-Based Drug Design #SBDDSummit #structurebaseddrugdesign #drugdesign #cryoem #xraycrystallography #nmr #structuralbiology

Alcami Corporation's Solid-State Characterization team has the expertise to design and execute crystal-form screening workflows and to comprehensively evaluate novel API forms. A solid-state study, including identification of new chiral modification of a long-known drug, guaifenesin, and detailed characterization and quantification were all part of a recent publication in “Crystal Growth and Design” titled: “Discovery, Characterization, and Solid-State Quantification of the Racemic Compound of Guaifenesin” Congratulations to Joanna Bis, Briana Graves, Frank Tarczynski, and Lukasz Wojtas on this publication! Read the article ➡️ https://hubs.li/Q02BxB4q0 #SolidStateCharacterization #Crystalformscreening #SolidStateQuantification #Discovery #casestudy #artinspiration #racemiccompound #smallmolecule #crystallization #CDMO #Alcami #research #APIscreening #published

🌟 We are thrilled to announce that our company is a proud sponsor of the 12th Peptoid Summit 🌟 💡 Peptoids have been making significant strides as potential therapeutics and self-assembling polymers for material development. With their unique structural properties and versatility of side chains, peptoids offer incredible potential in drug discovery and material sciences. 👨🔬 At Gyros Protein Technologies, we understand the importance of supporting scientific advancements, which is why we are committed to providing cutting-edge instrumentation that addresses the synthetic challenges posed by peptoids. ⭐ Our flexible software, induction heating technology, improved chemical compatibility, and inert experimental conditions enable the synthesis of challenging peptoids, leading to higher purity and efficiency. 👉 We proudly showcase how our instrumentation facilitates the parallel synthesis of high-purity peptoids and peptoid analogs, including the self-assembling diblock peptoid and the opioid receptor agonist peptoid-peptide hybrid. 🙌 We are eagerly looking forward to connecting with fellow innovators and researchers at the Peptoid Summit. #purepep #peptoid #synthesis

"Make or break questions for a drug discovery project often come down to, “does modulating this target do what we want?” and, “what else does modulating this target do?” In order to answer those questions quickly and make drug discovery decisions with confidence, an understanding of target engagement and corresponding on- and off-target effects on biology is critical. " https://lnkd.in/g3W2gTN5 #drugdiscovery #drugdelivery #decisiontools

I'm happy to share that our article titled 'Biolayer interferometry and its applications in drug discovery and development' was published in Trends in Analytical Chemistry! 😀 You can read it here: https://lnkd.in/dZUYWQfy

Nice overview of #labelfree BLI and #OctetBLI in particular for #drugdiscovery and development applications.