Mayo Clinic’s Post

Mayo Clinic announces a groundbreaking achievement in organ transplantation, offering hope to thousands who have lost their ability to speak, swallow and breathe on their own due to diminished function or loss of their larynx. A multidisciplinary team of doctors in Arizona performed the third known total larynx transplant in the U.S. The case also marks a medical milestone as the first known total larynx transplant performed as part of a clinical trial and the first on a patient with active cancer in the U.S. Read More: https://lnkd.in/dm-2Nbda “The surgery and patient’s progress have exceeded our expectations,” says David Lott M.D., chair of the Department of Otolaryngology (ENT) – Head and Neck Surgery/Audiology at Mayo Clinic in Arizona. “This is a tremendous accomplishment in launching what we believe is the future for laryngeal transplantation.” Six surgeons at Mayo Clinic conducted the 21-hour transplant, which included the larynx, pharynx, upper trachea, upper esophagus, thyroid and parathyroid glands, blood vessels, and nerves. #mededgemea #mayo #larynxtransplant #medicalmiracle #VoiceRestoration #SurgicalBreakthrough #TransplantSuccess #innovativesurgery #MedicalInnovation #VoiceRecovery #HealthcareAdvancements #surgicalachievement

SURGICAL ALTERNATIVE OF BIOPSY IN CAVERNOUS SINUS The etiology of cavernous sinus (CS) lesions remains difficult to determine due to the wide range of pathological processes and despite the development of neuroimaging techniques. Microsurgery is not yet appropriate to biopsy CS lesions for diagnostic purposes; computed tomography-guided fine-needle aspiration, which is mostly negative for malignancy, has rarely been attempted. I present to you a new application of endoscopic endonasal surgery for the biopsy of lesions that arise or invade the CS. Primary DBLCL in the cavernous sinus is extremely rare in clinical practice, early diagnosis is crucial to standardize neuro-oncological treatment and improve the prognosis of patients. We analyzed the case of a patient with diffuse large cell B lymphoma (germinal center maturation) that occurred in the cavernous sinus and orbit. Due to the poor prognosis of cavernous sinus lymphomas, whether primary or secondary, early diagnosis is essential. Our case demonstrates the need for physician awareness and the importance of maintaining a broad differential diagnosis.Under direct endoscopic visualization, the technique is safe, effective, precise and provides a surgical route that can be added to the arsenal for the treatment of pathological conditions in this region.

📃Scientific paper: Large retroperitoneal extraskeletal Ewing’s sarcoma with renal pedicle invasion: a case report Abstract: Background Extraskeletal Ewing’s sarcoma (EES) is a rare malignant tumor primarily found in children and young adults. Localized disease can present with nonspecific symptoms such as local mass, regional pain, and increased skin temperature. More severe cases may present with systemic symptoms such as malaise, weakness, fever, anemia, and weight loss. Among these lesions, retroperitoneal sarcomas are relatively uncommon and difficult to diagnose. Since they are usually asymptomatic until large enough to compress or invade the surrounding tissues, most are already advanced at first detection. Traditionally, the treatment of choice is complete surgical resection, sometimes combined with postoperative radiotherapy and chemotherapy. We report a case of EES with left renal artery invasion in the left retroperitoneal cavity successfully treated with transarterial embolization and surgery. Case presentation A 57-year-old woman with a negative family history of cancer presented at our Urology Department with a large left retroperitoneal tumor found by magnetic resonance imaging during the health exam. Physical examination showed a soft abdomen and no palpable mass or tenderness. Imaging studies showed that the tumor covered the entire left renal pedicle, but the left kidney, left adrenal gland, and pancreas appeared tumor free. Since the tumor tightly covered the entire renal pedicle, tumor excision with radical nephrectomy was advised. The patient underwent transarteria... Continued on ES/IODE ➡️ https://etcse.fr/Uwlcq ------- If you find this interesting, feel free to follow, comment and share. We need your help to enhance our visibility, so that our platform continues to serve you.

📃Scientific paper: Large retroperitoneal extraskeletal Ewing’s sarcoma with renal pedicle invasion: a case report Abstract: Background Extraskeletal Ewing’s sarcoma (EES) is a rare malignant tumor primarily found in children and young adults. Localized disease can present with nonspecific symptoms such as local mass, regional pain, and increased skin temperature. More severe cases may present with systemic symptoms such as malaise, weakness, fever, anemia, and weight loss. Among these lesions, retroperitoneal sarcomas are relatively uncommon and difficult to diagnose. Since they are usually asymptomatic until large enough to compress or invade the surrounding tissues, most are already advanced at first detection. Traditionally, the treatment of choice is complete surgical resection, sometimes combined with postoperative radiotherapy and chemotherapy. We report a case of EES with left renal artery invasion in the left retroperitoneal cavity successfully treated with transarterial embolization and surgery. Case presentation A 57-year-old woman with a negative family history of cancer presented at our Urology Department with a large left retroperitoneal tumor found by magnetic resonance imaging during the health exam. Physical examination showed a soft abdomen and no palpable mass or tenderness. Imaging studies showed that the tumor covered the entire left renal pedicle, but the left kidney, left adrenal gland, and pancreas appeared tumor free. Since the tumor tightly covered the entire renal pedicle, tumor excision with radical nephrectomy was advised. The patient underwent transarteria... Continued on ES/IODE ➡️ https://etcse.fr/Uwlcq ------- If you find this interesting, feel free to follow, comment and share. We need your help to enhance our visibility, so that our platform continues to serve you.

📃Scientific paper: Pelvic floor muscle training delivered via telehealth to treat urinary and/or faecal incontinence after gynaecological cancer surgery: a single cohort feasibility study Abstract: Purpose To assess the feasibility and clinical outcomes of telehealth-delivered pelvic floor muscle training (PFMT) for urinary incontinence (UI) and/or faecal incontinence (FI) after gynaecological cancer surgery. Methods In this pre-post cohort clinical trial, patients with incontinence after gynaecological cancer surgery underwent a 12-week physiotherapist-supervised telehealth-delivered PFMT program. The intervention involved seven videoconference sessions with real-time feedback from an intra-vaginal biofeedback device and a daily home PFMT program. Feasibility outcomes included recruitment, retention, engagement and adherence rates. Clinical outcomes were assessed at baseline, immediately post-intervention and a 3-month post-intervention using International Consultation on Incontinence questionnaires for UI (ICIQ-UI-SF) and Bowel function (ICIQ-B) and the intra-vaginal biofeedback device. Means and 95%CIs for all time points were analysed using bootstrapping methods. Results Of the 63 eligible patients, 39 (62%) consented to the study. Three participants did not complete baseline assessment and were not enrolled in the trial. Of the 36 participants who were enrolled, 32 (89%) received the intervention. Retention was 89% ( n =32/36). The majority of participants ( n =30, 94%) demonstrated high engagement, attending at least six videoconference sessions. Adherence to the daily PFMT program was moderate, with 24 participants (75%) completing five-to-seven PFMT... Discover the rest of the scientific article on es/iode ➡️https://etcse.fr/JAn7

Anatomical Distribution of Sentinel Lymph Nodes Harvested by Retroperitoneal vNOTES in 34 Consecutive Patients With Early-Stage Endometrial Cancer: Analysis of 124 Lymph Nodes Study objective: To determine the anatomical distribution of sentinel lymph nodes (SLNs), the overall, unilateral, and bilateral detection rates, and the bilateral SLN concordance in patients with endometrial cancer (EC) mapped through a retroperitoneal transvaginal natural orifice transluminal endoscopic surgery (vNOTES) approach. Patients were placed in a horizontal dorsal lithotomy position under general anesthesia, and indocyanine green (ICG) was injected into the cervix. Access to the retroperitoneal space was achieved through vaginal incisions. A 7 cm GelPoint V-Path Transvaginal Access Platform was used as a vNOTES port, and CO2 was insufflated to expand the retroperitoneal space. The pelvic retroperitoneal space was inspected for ICG uptake by lymph nodes. After identification, SLNs were removed and sent for definitive histological examination. Measurement and main results: A total of 34 patients were included in this study; 33 (97.1%) had a successful procedure (unilateral or bilateral mapping), and 1 (2.9%) had failed mapping. A total of 124 SLNs were identified and removed. SLNs were observed in the obturator region (81.5%), the external iliac region (10.5%), the internal iliac region (4.8%), and the common iliac region (3.2 %). Similar proportions were observed on both pelvic sides. No SLNs were detected in other regions. The SLN locations were symmetrical in 22/31 (71.0%) patients. SLNs were negatives in 120 cases (96.8%), while 2 lymph nodes (1.6%) presented isolated tumor cells, and 2 others (1.6%) presented macrometastases. Conclusion: We report anatomical distributions and detection rates for SLNs mapped by retroperitoneal vNOTES. Our results suggest substantial differences in the localization of SLNs compared to those reported for laparoscopic mapping. https://lnkd.in/eSAn9kgP Daniela Huber Yannick Hurni #ICG #indocyaninegreen #fluorescenceguidedsurgery #fluorescent #guidedsurgery #fluorescence #surgery #surgeon #imaging #thinkgreen #lymphnodes #endometrialcancer #patients

Surgery after neoadjuvant treatment with immune checkpoint inhibitors (ICIs) is safe for patients with locally advanced renal cell carcinoma (RCC). https://brnw.ch/21wFY8S

Publication Alert 📣 Our latest paper investigating the surgical treatment work-up of #gastric and #esophageal #cancer in Denmark by Astrid Kolind Christensen et.al. is out: https://lnkd.in/dD67Tepr Key Findings: * >950 patients were analyzed, undergoing both initial and specialized endoscopies prior to surgery. * 68% of initial endoscopies lacked sufficient preoperative tumor information. * In 12% of cases, findings from specialized endoscopies led to significant changes in surgical strategy. * Repeated endoscopy at specialized centers was identified as a critical factor in ensuring proper surgical treatment. This research underscores the importance of centralized care and specialized expertise in the treatment of #gastroesophageal cancer.

The Role of surgical MDT in the management of complex pelvic surgery is rapidly evolving , we are delighted to share the value of stepwise pelvic devascularization for patients refusing blood transfusion #cancer #surgeons #oxforduniversity #share #healthcareinnovation #medicine #knowledge #surgery #oncology #oncologists #keynotespeaker #keynotespeakers #patientsafety #patientexperience Nick Symons #patientsafety #patientexperience #nhs #nhsengland