MBL International Corporation’s Post

Non-consecutive enzyme interactions within TCA cycle supramolecular assembly regulate carbon-nitrogen metabolism Enzymes of central metabolism tend to assemble into transient supramolecular complexes. Here, the authors stoichiometrically perturbed the supramolecular complex of TCA cycle enzymes in B. subtilis and propose that MDH-ICD clustering causes 2-oxoglutartae sequestration by reducing its diffusion rate, a mechanism that has evolved to regulate flux through the carbon-nitrogen metabolic branch-point. https://lnkd.in/grK-9QTt

Discover the fascinating world of lipid metabolism! 🧬🔬 Lipid metabolism plays a crucial role in how our bodies store and use energy, impacting everything from cell structure to hormone production. Dive into the science behind it and understand how our cells manage fats for energy and health! #mls #lipid #energyneeds #Biochemistry #LipidMetabolism #HealthScience #MolecularBiology #lpu #thinkbig

Discover the fascinating world of lipid metabolism! 🧬🔬 Lipid metabolism plays a crucial role in how our bodies store and use energy, impacting everything from cell structure to hormone production. Dive into the science behind it and understand how our cells manage fats for energy and health! #mls #lipid #energyneeds #Biochemistry #LipidMetabolism #HealthScience #MolecularBiology #lpu #thinkbig

Coenzyme A biosynthesis: mechanisms of regulation, function and disease This Review summarizes the fundamental aspects related to coenzyme A synthesis and its implications as a central molecule in metabolism. https://lnkd.in/gNgm2jbT

📢Interesting #Review: Considering Strain Variation and Non-Type Strains for Yeast Metabolic Engineering Applications 🎓 by Dr. Hal S. Alper and Mr. Xiunan Yi from The University of Texas at Austin. 👉Enjoy reading: https://lnkd.in/epkuy_Su #metabolic engineering; #yeast cell factory; #non-type strains; #strain variations; #strain selection

Gut microbiota acts like an auxiliary liver Microbes in the mammalian gut can significantly change their hosts’ amino acid and glucose metabolism, acting almost like an extra liver, according to a new preclinical study by investigators. The researchers found that by consuming a specific class of amino acids, gut microbes can alter their hosts’ blood glucose homeostasis. Further analysis revealed that by changing amino acid availability, the microbes appear to affect the production of the neurotransmitter serotonin, which in turn changes glucose regulation. “A lot of these metabolic functions can be done by the liver, but now we’ve found that there are functionally comparable enzymes encoded by the gut microbiota that can do the same or similar things,” said the author. “It’s like there is a second liver operating in the gut.” The team is now designing new strategies to modulate the bacterial enzymes more precisely, and looking at how various combinations of bacteria affect the host’s amino acid metabolism. #ScienceMission #sciencenewshighlights https://lnkd.in/gttgZtxE

Source: Discovery medicine This study investigates the changes in central carbon metabolism (CCM) before and after metformin treatment for type 2 diabetes (T2D) using mass spectrometry. The researchers analyzed metabolites in individuals with T2D, some of whom received metformin treatment, and healthy subjects. They found that metformin treatment normalized levels of certain metabolites in the CCM pathway, including cyclic AMP, glucose 6-phosphate, l-lactic acid, maleic acid, and malic acid. These metabolites were associated with pathways such as pyruvate metabolism, tricarboxylic acid cycle, propanoate metabolism, and glycolysis or gluconeogenesis. The study suggests that metformin may improve the energy metabolism imbalance in T2D by reducing intermediates in the CCM pathway.

Sulfate metabolism via the gut microbiome has been known about for a long time by those in microbiome research, particularly in relation to hydrogen gas production. However the sulfated metabolome, which comprises of sulfate containing small molecules, has long been overlooked and considered mere waste products. This brilliant 2024 review in Nature Chemical Biology by D'Agostino, Chaudhari, and Devlin further shines a light on the biological activities and roles of sulfated metabolites in host-microbiome interactions. Key Insights: 🔬 Sulfated metabolites possess immunoregulatory, neuromodulatory, and disease-modifying properties, contrary to the traditional view of them as inert waste. Compounds like indoxyl sulfate, p-cresol sulfate, and 4-ethylphenyl sulfate can influence chronic kidney disease, autism spectrum disorder, and cardiovascular disease. 🦠 The gut microbiome plays a crucial role in modulating the sulfated metabolome through collaborative metabolism with the host. Bacterial enzymes can sulfonate, desulfate, and interconvert various metabolites, including carbohydrates, amino acid derivatives, and cholesterol-derived compounds. 💡 New analytical techniques have enabled the detection of hundreds of previously unknown sulfated metabolites, opening up avenues for their use as disease biomarkers and potential therapeutic targets. It really make me happy to see new review highlighting the intricate interactions between the host and its microbiome. It provides further confirmation of the need to explore these once-overlooked molecules and their potential in disease detection, prevention, and treatment. #SulfatedMetabolome #HostMicrobiomeInteractions #MetabolicResearch #GutMicrobiome #SulfurMetabolism

Start your month with the best papers on #mitochondria and #metabolism. 👉 In patients with HFpEF, treatment with Dapagliflozin improved systemic arterial compliance and venous capacitance during exercise 👉 SLC25A48 controls mitochondrial choline import and metabolism. The full list is here 👇👇 👇 https://lnkd.in/gfe2hzYg Thanks Biomed News for pre-selection. #science #technology #machinelearning

NAD (Nicotinamide Adenine Dinucleotide) is a crucial coenzyme found in all living cells. It plays a vital role in metabolism by participating in redox reactions. NAD exists in two forms: NAD+ (oxidized) and NADH (reduced). Maintaining optimal NAD levels is crucial for healthy aging and overall cellular function. Brief History of NAD: NAD was first discovered by British biochemists Arthur Harden and William John Young in 1906 during their research on fermentation. They noticed an unknown factor that accelerated the fermentation process, which they later identified as NAD. In the 1930s, German-American biochemist Otto Warburg further elucidated the structure and function of NAD. He demonstrated its role in hydrogen transfer and its importance in cellular respiration. In 1929, Arthur Harden and Hans von Euler-Chelpin were awarded the Nobel Prize in Chemistry for their research on the fermentation of sugar and fermentative enzymes, which included studies on NAD. In recent decades, NAD has gained significant attention for its role in aging and disease. Research has shown that NAD levels decline with age, and boosting NAD can improve cellular function and longevity. This has led to the development of NAD supplements and precursors aimed at enhancing healthspan.