MD Biosciences Neuro’s Post

Elucidating the underlying molecular alterations in Alzheimer’s Disease (AD) pathology is essential for understanding disease mechanisms and developing effective therapeutic interventions. Multiplexed imaging techniques such as MERFISH have emerged as powerful tools for comprehensive molecular and cellular profiling at single-cell resolution. Download our poster presented by Dr. Bin Wang, PhD at SFN 2023 to learn how we used MERSCOPE Protein CO-detection to study the spatial distribution of biomarkers and cellular heterogeneity of a normal aging human brain sample and a human AD brain sample: https://lnkd.in/etzgf5NF #SFN23 #Vizgen #MERSCOPE #MERFISH #SpatialTranscriptomics #SpatialGenomics #Neuroscience #BrainScience #CellAtlas #AlzheimersDisease #SpatialData #DataAnalysis #ProteinCoDetection #SpatialMultiomics

The on-demand video of our recent webinar is now available! https://hubs.la/Q02Lsmhz0 Discover the latest insights on overcoming challenges in developing post-surgical pain agents. We dive into the critical role of large animal models for surgical pain and highlight a success story of translating the pig post-operative pain model to the clinic. #TranslationalResearch #PainResearch #Neuroscience #PreclinicalResearch #PostOperativePain #TranslationalMedicine #SurgicalPain #PreclinicalModels #DrugDevelopment #Webinar #CNSResearch #PainManagement

https://lnkd.in/eMK84xK4 Happy to share my 1st author publication from Kessen Patten Lab. We developed an ImageJ macro called “NMJ Analyser” to automatically and unbiasedly analyse NMJ morphology in zebrafish. It can enable high-throughput NMJ phenotypic screens in the drug discovery process for NMDs. We have equipped it with advanced mode which could also be further applied to the investigation of NMJ or other puncta/point staining of other developmental systems. #zebrafish #neuroscience #neuromuscular #dataanalysis #bioinformatics

Check out our peer-reviewed Parkin #antibody—a pivotal protein in #Parkinsons pathology. Tested for WB, IP, IHC-P, IF + FC with human, rat and mouse reactivity. Learn more: https://hubs.li/Q02qz46h0 #ParkinsonsResearch #Neuroscience #research

Did you miss our presentation on the diagnosis of Alzheimer’s disease pathology using a novel blood-based assay? Watch an on-demand presentation from Henrik Zetterberg, PhD, and Kaj Blennow, PhD, for a deep dive into how the ALZpath novel plasma pTau217 immunoassay identifies abnormal amyloid-ß and tau pathologies at various clinical stages from plasma samples. Topics they covered include: • The results obtained from Wisconsin’s Registry for Alzheimer's Prevention (WRAP) in relation to pTau217 and the practical aspects of high-throughput sample analysis • pTau217’s superior solo performance compared to pTau217/non-pTau212-221 ratio • The advancements in developing an easy-to-use, highly accurate blood-based AD test Watch on-demand today: https://hubs.li/Q02nqBJd0 #pTau217 #Alzheimers #neuroscience #ClinicalResearch #AlzheimersDisease #AlzheimersResearch #AlzheimersAssociation #AlzheimersSociety #diagnostics #biomarkers

Cellular models of neurodegenerative diseases play an integral role in preclinical drug discovery, and safety studies. Patient iPSC-derived dopamine neurons along with Multi-Electrode Array (MEA) assay provide a useful platform to investigate functional phenotypes both at the individual neuron and network levels. CRL now offers testing of small molecules aimed at reversing pathophysiology linked with cellular models of neurodegenerative diseases. For more details contact our client service https://lnkd.in/eGbNJsNC or connect with our specialists Amit Kumar Chouhan, PhD, Eddie Burns and Dario Magnani #CharlesRiver #drugdevelopment #Pharmacology #neuroscience #drugdiscovery #neurology #neurodegeneration #parkinsonsdisease Follow us at Discovery | Charles River

#alhumdulillah I'm thrilled to announce the publication of our manuscript, "Autophagy-associated non-coding RNAs: Unraveling their impact on Parkinson's disease pathogenesis," in CNS Neuroscience & Therapeutics (Impact Factor: 5.5). This study explores the critical role of non-coding RNAs in regulating autophagy processes, offering new insights into their potential as therapeutic targets for Parkinson's disease. Our findings highlight the complex interplay between these RNAs and the pathogenesis of Parkinson's, opening avenues for novel treatment strategies. A great thanks to all the co-authors (Professors) Mahamedha D., sachin singh, Kamal Dua, Vetriselvan Subramaniyan, Ph.D., FMSA., Access the full manuscript here: https://lnkd.in/gGDgy5p5 #Neuroscience #ParkinsonsDisease #Autophagy #NonCodingRNAs #Research #OpenAccess #CNSNeuroscienceTherapeutics

Excited to announce the release of this important article on midbrain organoids and alpha-synuclein aggregation, a significant advancement in modeling Parkinson's disease in vitro 🧠 This paper titled "Exploring Alpha-synuclein Pathology: Insights from a Midbrain Organoid Model of Familial Parkinson's Disease" shows the results of many years of work on the field of alpha-synuclein aggregation and astrocyte senescence 🔬 Find it now at Molecular and Cellular Neuroscience ➡ https://lnkd.in/gfp-NTzs #ParkinsonsResearch #Neuroscience #organoids #senescence

Our research on Charcot-Marie-Tooth (CMT) disease is making waves at #SfN23! We are proud to announce that PsychoGenics showcased 9 posters this year, with 3 focused on CMT. Check out this snapshot of Assistant Director Herman Fernandes presenting his poster, "Characterization of two rodent models of CMT1A to aid the preclinical evaluation of potential new Charcot-Marie-Tooth therapies." #CMTAwareness #Neuroscience #SocietyforNeuroscience

Researchers observed increased expression of neuroprotective genes related to proteostasis, phagocytosis, and protein clearance in astrocytes and microglia, suggesting their crucial role in responding to amyloid-beta and pTau pathology in Alzheimer's disease (AD). The identification of distinct sub-clusters within these cells, along with coordinated functionality of AD biomarkers like CLU in astrocytes and GPNMB in microglia, provides insights into the complex molecular mechanisms of the disease. A noteworthy study by Smith et al. “Diverse human astrocyte and microglial transcriptional responses to Alzheimer’s pathology” #Alzheimers #AD #Dementia #AlzheimersResearch #Neuroscience #snRNA #singlenuclei #BioTuring Read the publication here: https://lnkd.in/gErTkF2V Explore the dataset on Talk2Data now: https://lnkd.in/gYzhqTEs