MedChemExpress LLC’s Post

New breakthrough in demyelinating disease research! 👏 👏 👏 In a recent publication in the journal Signal Transduction and Targeted Therapy, researchers investigated the potential molecular mechanism between Cadm4 (Cell Adhesion Molecule 4) and demyelinating diseases. 🤩 🤩 🤩   Researchers revealed that Cadm4 undergoes specific palmitoylation at cysteine-347, which is crucial for its stable localization on the plasma membrane. Mutation of C347 to alanine blocks palmitoylation, leading to the internalization and degradation of Cadm4. In vivo experiments showed that the C347A mutation causes severe myelin abnormalities in the central nervous system. The researchers also identified zinc finger DHHC-type palmitoyltransferase 3 (ZDHHC3) as the enzyme responsible for catalyzing Cadm4 palmitoylation. Depletion of ZDHHC3 reduces Cadm4 palmitoylation, impairing its plasma membrane localization and resulting in myelin defects similar to those observed in the Cadm4-KI mouse model. Altered Cadm4 palmitoylation impairs neuronal transmission and cognitive behavior. Additionally, attenuated ZDHHC3-Cadm4 signaling significantly influences neuroinflammation in various demyelinating diseases. Mechanistically, the study also demonstrated the predominant expression of Cadm4 in the oligodendrocyte lineage and its potential role in modulating cell differentiation via the WNT-β-catenin pathway.   The findings of this publication suggest that deregulated ZDHHC3-Cadm4 signaling leads to myelin abnormalities, providing new insights into the common pathological mechanisms underlying neuroinflammation-associated demyelinating diseases. 💥 💥 💥   https://lnkd.in/eeXiHHZA   For more push, please follow #Twitter: https://lnkd.in/gntQ9qE7   Related Product Recommendation:   #Cycloheximide (Actidione; Naramycin A; https://lnkd.in/etmc8HQX);   #MG132 (Z-Leu-Leu-Leu-al; MG-132; https://lnkd.in/gy33AFtQ);   #3Methyladenine (3-MA; https://lnkd.in/g3x3PJpB);   #Dynasore (https://lnkd.in/grNjThEp);   #Chloroquine (https://lnkd.in/gh5VwhBU);   #2BromohexadecanoicAcid (2-Bromopalmitic acid; 2-Bromopalmitate; https://lnkd.in/es5JpdHA)   #SignalTransductionandTargetedTherapy #PertussisToxin #ZDHHC3 #Cadm4 #DemyelinationDiseases #Neuroinflammation #MCE #MedChemExpress

🌟 Torin 1: Unleashing the Power of Gluconeogenesis against Cancer🌟 In the ever-evolving landscape of cancer biology, a fascinating discovery has emerged - the role of gluconeogenesis in combating cancer. Researchers have uncovered a novel mechanism by which the mTOR (mechanistic target of rapamycin) inhibitor, Torin 1, can effectively target cancer cells. Torin 1 is a Potent mTOR Inhibitor for Kinds of Cancers Research 🔍 Key Insights: ✅ Inhibition of mTOR leads to the upregulation of the gluconeogenesis pathway in cancer cells. ✅ This upregulation of gluconeogenesis creates a "futile" cycle, as depicted in Figure 1. ✅ This cycle significantly contributes to apoptosis in cancer cells, particularly in hepatocellular carcinoma (HCC) and renal cell carcinoma (RCC), where the expression of gluconeogenesis-related genes is notably reduced. ✅ The detrimental effect of this futile cycle is significant. Reducing the expression of the rate-limiting enzyme PCK1 in the gluconeogenesis pathway could prevent this cycle from initiating and substantially reduce apoptosis in cancer cells after mTOR inhibition. By targeting this pathway, Torin 1 demonstrates promise as a therapeutic strategy in the fight against cancer. 👉 Read more about this groundbreaking research here. https://lnkd.in/gnYFrXag #CancerResearch #mTOR #Torin1 #HepatocellularCarcinoma #RenalCellCarcinoma #Gluconeogenesis #Oncology

(English below) 🔬✨ Cette semaine, MedChemExpress a participé au 30e congrès du Club Hématopoïèse et Oncogenèse (CHO) sur la magnifique presqu'île de Giens. Cet événement incontournable en oncologie et hématologie a réuni des chercheurs de renom. Nous avons eu l’opportunité de présenter notre portfolio de produits, incluant nos modulateurs de voies de signalisation, protéines recombinantes, anticorps, et marqueurs fluorescents, des solutions indispensables pour les projets de recherche. À ne pas manquer : Profitez de notre -30% sur les chimiothèques bioactives [https://lnkd.in/ewNd3cWw] et sur une sélection de produits Life Science [https://lnkd.in/emHuuSRC] ! Merci à Catherine Sawai et Marie-Laure Arcangeli pour l'organisation de cette rencontre et merci à tous ceux qui sont venus échanger avec nous. 👩🔬👨🔬 _________________________________________________________________________________ 🔬✨ This week, MedChemExpress participated in the 30th Congress of the Club Hématopoïèse et Oncogenèse (CHO) on the beautiful Giens Peninsula. This must-attend event in oncology and hematology brought together renowned researchers. We had the opportunity to showcase our product portfolio, including our signaling pathway modulators, recombinant proteins, antibodies, and fluorescent markers—essential solutions for research projects. Don’t miss out: Take advantage of our 30% off on bioactive compound libraries [https://lnkd.in/ewNd3cWw] and a selection of Life Science products [https://lnkd.in/emHuuSRC]! Thank you to everyone who stopped by for a chat. 👩🔬👨🔬 #Oncology #LifeScience #Hematology #SmallMolecules

🌟 Exploring the Role of Substance P in Neuroscience Research 🌟 🎈 In the fascinating world of neuropeptides, Substance P (SP) stands out for its significant role in various physiological processes, including pain perception and neurogenic inflammation. Recent studies have provided insights into its mechanisms of action, particularly its interactions with neurokinin receptors, shedding light on potential therapeutic avenues. 👏 At MCE, we offer high-quality Substance P (Catalog No. HY-P0201), specifically designed for research applications.  👉 For more detailed information: https://lnkd.in/gvKGaqdw Our product is ideal for researchers looking to delve deeper into the physiological and pharmacological properties of this vital neuropeptide. 🔗 Explore Substance P here：https://lnkd.in/gNWH2ZcW #SubstanceP #Neuroscience #MCE #Neuropeptides #Cryoelectronmicroscopy #Hormonereceptors

🥳🎉 MedChemExpress LLC North America #Year-#End #Celebration is still ongoing! 🤩 Enjoy a limited-time 💲20% discount on a variety of #products! Invite your friends to join this year-end #event and share in the joy! Come celebrate this special moment with us! 😊   🔽 For More Information: https://lnkd.in/gun9-8E2   #YearEndCelebration #Event #October #Promotion #EndofYear #Activity #Products #Sales #MysteryGift #Gift #RecombinantProteins #FluorescentDye #Antibodies #InhibitoryAntibodies #Kits #siRNAs #miRNAs #LNPs #IsotopeLabeledCompounds #Research #MedChemExpress

🚀 Exciting News! In #September, MedChemExpress LLC added over 1,000 #new #molecules to our database! 🌟 This batch of MCE recommends #clinical #compounds include NDI-101150, HRS-4642, VK-0214, and Rifasutenizol (TNP-2198), all of which are key players in the various research as #cancer and #neurological #diseases. 🌟 Additionally, we're highlighting oral active molecules targeting popular #pathways such as #BTK, #BDK and #SEPTIN6. 🤩 Stay tuned for more updates as we continue to drive innovation in drug discovery!

👉 Join the Discussion! 📢 MCE Webinar - Ex Vivo Drug Response Profiling in Clinical Application ⭐ How ex vivo drug response profiling can reveal genotype–drug response associations ⭐ The feasibility and clinical impact of ex vivo drug response profiling for personalized treatment guidance in hematologic malignancies ⭐ Future potential application of ex vivo drug response profiling in precision medicine 🙌 Speaker: Peter-Martin Bruch, Resident Physician and Physician Scientist, University Hospital Düsseldorf / Recipient of the Franziska-Kolb-Foundation Research Award ⌛ Register and join the discussion on 14, November. https://lnkd.in/eP88NfAr #webinar #precisionmedicine #Exvivo #Drugresponse #PersonalizedTreatment #MCE #Cancer #CancerResearch #MedChemexpress

📢 October 17, 2024 🤗 MedChemExpress LLC North America will be at Indiana University School of Medicine (#IUPUI) this Thursday for the show. You can meet us at the show and learn more about MedChemExpress. We are excited to meet you. 🤝   📍 Location: Campus Center, 4th Floor, 420 University Boulevard, Indianapolis, IN 46202 🕚 11:00AM - 1:00PM 🔽 For More Information: https://lnkd.in/eXGE3XQC   #lifesciences #molecules #research #smallmolecules #university #show #MedChemExpress

(English below) ✨ Nous sommes ravis d’avoir participé au 19e congrès national de la Société Française de Microbiologie "Bienvenue chez les Microbes" à Lille ! 🌱🔬 Notre stand a attiré de nombreux visiteurs, curieux de découvrir nos produits phares dans le domaine des Life Sciences, notamment : 🔹 Marqueurs fluorescents 🔹 Peptides/Oligonucléotides 🔹 Anticorps 🔹 Produits naturels 🔹 Kits de culture d'organoïdes, et bien d'autres 🌿🧬 Profitez de notre offre spéciale de fin d'année : -30% sur une sélection de produits Life Science. Pour en savoir plus, cliquez sur ce lien : https://lnkd.in/emHuuSRC Nos goodies ont fait fureur, et nous sommes ravis d'avoir pu interagir avec autant de passionnés du secteur. Nous sommes également ravis d'annoncer que notre équipe française s'est agrandie avec l'arrivée de Juba G. ! Nous vous remercions pour votre visite et espérons vous revoir lors de nos prochains événements! 👋 _________________________________________________________________________________ ✨ We are delighted to have participated in the 19th National Congress of the French Society of Microbiology "Welcome to the Microbes" in Lille! 🌱🔬 Our booth attracted many visitors eager to discover our flagship products in the field of Life Sciences, including: 🔹 Fluorescent markers 🔹 Peptides/Oligonucleotides 🔹 Antibodies 🔹 Natural products 🔹 Organoid culture kits, and many more 🌿🧬 Take advantage of our year-end special offer: -30% on a selection of Life Science products. To learn more, click on this link: https://lnkd.in/emHuuSRC Our goodies were a hit, and we are thrilled to have interacted with so many enthusiasts from the industry. We are also pleased to announce that our French team has expanded with the arrival of Juba G.! Thank you for your visit, and we hope to see you at our upcoming events! #LifeScience #SmallMolecules #Microbiology