Medicines for Malaria Venture’s Post

Malaria remains a major global health threat, affecting 249 million people and causing 608,000 deaths in 2022. However, traditional treatments like Artemisinin-based therapies (ACTs) are becoming less effective as resistance develops. Researchers from the Antimicrobial Resistance (AMR) IRG, in collaboration with Columbia University Irving Medical Center (CUIMC) and Nanyang Technological University Singapore (NTU Singapore), have discovered a link between malaria drug resistance and a cellular process called transfer RNA (tRNA) modification. This groundbreaking discovery advances our understanding of how malaria parasites adapt to drug-induced stress and develop resistance; it is a significant step forward in malaria research and holds great potential for developing new drugs to tackle this issue. Learn more about this breakthrough on our blog. #SMARTMIT #AMR #AntimicrobialResistance #Malaria #GlobalHealth #PublicHealth #Research #MedicalResearch #MalariaTreatment

🦠A study has reveled a potential game-changer in the fight against deadly Nipah virus! 🌍 👩🔬 Researchers have discovered that a humanized monoclonal antibody, hu1F5, could be the key to protecting against this highly infectious and often fatal virus. 💉 🦇 Nipah virus, originating from fruit bats, poses a significant threat with its acute respiratory distress syndrome and encephalitis, leading to over 90% fatality rates in humans! 😱 🛡️ But hu1F5 has shown remarkable effectiveness in neutralizing the virus, offering hope for potential treatments. 💪 🔬 Conducted by a collaborative team of scientists from Mapp Biopharmaceutical, University of Texas Medical Branch, and more, this study marks a significant milestone in medical research.🌟 🔍📰Dive deeper into this research by checking out the full article: https://lnkd.in/gAvAv5Nq . . . . . . . . . . . . . . #MedicalBreakthrough #NipahVirusResearch #MonoclonalAntibody #HealthcareHeroes MedBound Times NewsGram M Subha M. Sonali Pradhan Jyoti Shukla Dr Anjali K V Susmita Bhandary Munish Kumar Raizada, MD, FAAP Lavanya Beeraboina Dr.Vineesha Vasudevan Himani Negi Nirainila Joseph Aniket Bakare Akashita Panjla

Extracellular vesicles (EVs) act as a potent weapon to wield several pathogens and modulate host immune response. These EVs, measuring between 30-150 nm, harbor a plethora of molecules capable of suppressing the immune defenses. Research from Indian Institute of Technology, Mandi unveiled an interesting feature of Taenia solium (tape worm) EVs which are packed with molecules and metabolites that sabotage the PI3K/AKT pathway, upon internalization by host macrophages, resulting in reduced reactive oxygen species (ROS) production and impaired bacterial clearance, coupled with a surge in macro-autophagy and caspase-linked apoptosis. This cascade of events not only push macrophages for self-destruction, but also suggests a clever immunosuppressive strategy during the early, often asymptomatic, stages of neurocysticercosis. Interestingly, the research also reveals another aspect that T. solium EVs act as protectors against DSS-induced colitis in mice, suggesting future therapeutic opportunities for inflammatory diseases. The study suggests reshaping of our approach to combat parasitic infections and inflammatory diseases alike. DOI: https://lnkd.in/gRQKvN5u Rajesh Gokhale Department of Biotechnology Indian Institute of Technology, Mandi

Sharing our latest comprehensive review on cholangiocarcinoma - a #rarecancer of the bile duct that is more prevalent in Asia. This work is a collaborative effort from colleagues in Singapore, India, Thailand and China, documenting endemic risk factors for the disease (such as liver parasites and herbal carcinogens) and summarizing recent treatment advances. Khosla D, Misra S, Chu PL, Guan P, Nada R, Gupta R, Kaewnarin K, Ko TK, Heng HL, Srinivasalu VK, et al. Cholangiocarcinoma: Recent Advances in Molecular Pathobiology and Therapeutic Approaches. Cancers. 2024; 16(4):801. https://lnkd.in/gJTp_RmB #starlightinitiative #rarecancer #rarecancersg #cholangiocarcinoma

"WEEK BY WEEK, OIL BY OIL" SERIES - BASIL OIL: MALARIA’S ANSWER? Malaria, transmitted by female Anopheles mosquitoes, is caused by the Plasmodium parasite. It poses significant health risks, especially Plasmodium falciparum, due to drug resistance. Resistance to antimalarial drugs, particularly in endemic regions, increases morbidity and mortality. Genetic mutations in Plasmodium genes often lead to resistance, necessitating the development of affordable antiprotozoal agents. To address drug resistance challenges, researchers explore alternative malaria treatments. One avenue is investigating natural compounds like those found in basil oil. In a study by Mabubu J.I. (2015), crude ethanol extracts of wild basil leaves showed significant inhibition of P. falciparum growth in vitro. Further examination focused on Sesquiterpene lactones isolated from basil extract, identifying 11 compounds with potential antimalarial activity. These compounds were assessed for inhibiting dihydrofolate reductase, a critical enzyme in nucleic acid biosynthesis in protozoa and bacteria. This research hints at basil oil's potential for new antimalarial drug development. Additionally, there are numerous other studies investigating and discovering the antimalarial properties of basil #weekbyweek_oilbyoil_series #basiloil #essentialoil #Vietnamessentialoils #therapeutic #fragrances #aromatherapy #comestic #pharmeceutical #vipsen #rosienguyen

There is a growing interest in the potential of African medicinal plants to support the immune system and address health issues like sickle cell disease. These plants are rich in bioactive compounds that can boost the immune system and potentially treat various diseases. However, there is a gap in understanding the African genome, which is crucial for developing targeted treatments for diseases like sickle cell. Sickle cell disease is a genetic condition that affects the shape of red blood cells and is more prevalent in populations with African ancestry. The protective effect of the sickle cell trait (AS genotype) against malaria has led to a higher prevalence of this trait in many parts of Africa. To address this gap, there have been calls for establishing African genomics and bioinformatics programs through annual regional workshops. This would help in understanding the genetic basis of diseases like sickle cell and developing more effective treatments. In addition to the genetic factors, there is also a need to explore the potential of African medicinal plants in treating diseases like sickle cell. For example, a compound that activates a fetal gene has shown promise in treating sickle cell disease, offering new hope for patients. Overall, a combination of genomics research and the exploration of African medicinal plants could lead to more effective treatments for diseases like sickle cell, especially in regions where these diseases are more prevalent.

"A #research team from Fudan University in #Shanghai explained how they found that an artemisinin derivative improved #symptoms in mouse and rat models of #PCOS by repressing a key disease mechanism" Today's #KCRScienceRead highlights research that suggests artemisinins, a group of drugs derived from the leaves of the sweet wormwood plant, may have the potential to effectively treat new conditions. Check it out! https://lnkd.in/e9sNNS7K #KCRScienceRead #KCRCRO #ClinicalTrials #ClinicalResearch #DrugDiscovery #Malaria

The tick-borne encephalitis virus must mature to be infectious 🦠 Tick-borne encephalitis is a serious neurological disease caused by the tick-borne encephalitis virus 🧠 An international team of scientists led by Pavel Plevka from CEITEC - Central European Institute of Technology Masaryk University and Sarah Butcher from the University of Helsinki focused their research on unraveling the structure of the non-infectious, immature tick-borne encephalitis virus particle and described in detail the interactions of the virus envelope proteins and the differences in their arrangement on the surface of the immature particle compared to the mature, infectious particle 🔬 The conclusions of their study expand the portfolio of knowledge about tick-borne encephalitis virus and may lead to the development of new antiviral drugs targeting virus maturation in the future 🛑 Read more here ➡ https://lnkd.in/dxaq3Fha #CEITECScience Národní institut virologie a bakteriologie #virus #TBEV #research #science #brnoregion #czechrepublic

Synthesis and In Vivo Profiling of Desymmetrized Antimalarial #Trioxolanes with Diverse Carbamate Side Chains. Despite notable progress in the #preclinical arena, malaria remains a cause of significant mortality, particularly in sub-Saharan Africa. #Artemisinin-based combination therapy, the standard treatment for uncomplicated malaria, and intravenous artesunate, the standard for severe malaria, are threatened by the increasing prevalence of artemisinin partial resistance (ART-R), which has recently emerged in eastern Africa. The recent #withdrawal of #artefenomel from clinical development leaves no #endoperoxide-class agents in the antimalarial pipeline, Synthetic endoperoxides with a desymmetrized structure have demonstrated promising physiochemical and in vivo properties.

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