Microfluidics’ Post

Nanoparticle albumin bound (nab) technology is one of the most useful delivery platforms, especially for drugs such as chemotherapeutics. Chemotherapeutics continues to be a major challenge, due to their high toxicity, low aqueous solubility and poor bioavailability. In addition, traditional solubilizing and delivery vehicles are cytotoxic and can lead to severe allergic reactions. Nanoparticle albumin bound (nab) technology is a novel and attractive platform. Albumin is a natural and abundant protein occurring in plasma, which means it is not only biocompatible and biodegradable, but also non-toxic and non-immunogenic. Creating stable nanoemulsions enables this drug to be successful. In this Application Note, we look at how Microfluidizer® Technology plays a vital role in safely producing nab paclitaxel with high shear homogenization. Learn more: https://hubs.la/Q02KK4_70 #nanoparticlealbuminboundtechnology #chemotherapeutics #Microfluidics #nabtechnology #Microfluidizerprocessors #nanoemulsions

𝗣𝗼𝘄𝗲𝗿𝗳𝘂𝗹 𝗧𝗼𝗼𝗹𝘀 𝗳𝗼𝗿 𝗣𝗿𝗲𝗰𝗶𝘀𝗲 𝗘𝗻𝗴𝗶𝗻𝗲𝗲𝗿𝗶𝗻𝗴 𝗼𝗳 𝗩𝗶𝗮𝘁𝗲𝗹 𝗗𝗶𝗯𝗹𝗼𝗰𝗸 𝗡𝗮𝗻𝗼𝗽𝗮𝗿𝘁𝗶𝗰𝗹𝗲 𝗦𝗶𝘇𝗲: 𝗣𝗼𝗹𝘆𝗺𝗲𝗿 𝗮𝗻𝗱 𝗦𝗼𝗹𝘃𝗲𝗻𝘁 𝗦𝘁𝗿𝘂𝗰𝘁𝘂𝗿𝗲 Nanomedicine has immense potential as it offers nanoparticle(NP)-based delivery vehicles for vaccines or APIs. Polymeric NPs have been used for drug delivery due to their biocompatibility, biodegradability and potential to provide customized properties by tailoring polymer chemistry. NP size is a critical factor that impacts circulation time, in vivo biodistribution and cell uptake[1-3]. Also, NPs < 200 nm can be sterile filtered. Thus, it is crucial to control NP size. Herein, we determined the most effective factors to control NP size. View the poster presented at CRS Bologna 2024 by Ashland: https://lnkd.in/dSARtTNz

𝗘𝘅𝗽𝗹𝗼𝗿𝗶𝗻𝗴 𝘁𝗵𝗲 𝗜𝗺𝗽𝗮𝗰𝘁 𝗼𝗳 𝗣𝘂𝗺𝗽 𝗧𝗲𝗰𝗵𝗻𝗼𝗹𝗼𝗴𝘆 𝗼𝗻 𝗟𝗡𝗣 𝗙𝗼𝗿𝗺𝘂𝗹𝗮𝘁𝗶𝗼𝗻 RNA based therapies are poised to change biotechnology for years to come. But the production of these therapies poses new challenges. For instance, in Formulation of Lipid Nanoparticles or LNP, an aqueous buffer containing RNA and an organic solvent containing lipids are mixed in a controlled manner. The flow of these two liquids needs to be delivered at highest accuracy and repeatability to achieve desirable encapsulation and particle attributes. Too high or too low flow of one or both streams can lead to undesirable particle size, polydisperse size distribution or reduced encapsulation.   Discover the impact of pump technology on LNP formulation and how Levitronix® PuraLev® pumps are set to revolutionize the RNA-based therapy production industry. Industry data available: https://lnkd.in/eC3b7dj5 #RNAformulation #RNAtherapies #bioprocessing #biotechnology #biomanufacturing #LNP #LNPformulation #pumptechnology #pumpsystems #levitronix

LNP Formulation – How Flow Pulsations Influence LNP Yield RNA based therapies are poised to change biotechnology for years to come. But the production of these therapies poses new challenges. For instance, in Formulation of Lipid Nanoparticles or LNP, an aqueous buffer containing RNA and an organic solvent containing lipids are mixed in a controlled manner. The flow of these two liquids needs to be delivered at highest accuracy and repeatability to achieve desirable encapsulation and particle attributes. Too high or too low flow of one or both streams can lead to undesirable particle size, polydisperse size distribution or reduced encapsulation. In this video, you will discover the impact of pump technology on LNP formulation and how Levitronix® PuraLev® pumps can help achieve high yield. https://lnkd.in/gur9Tbwp

Accurate and efficient #CellSorting and dispensing with on-chip electrodes and micron-sized outlet channels. Read about Enplas's cell sorting and #Microfluidic development in our brochure: https://bit.ly/4a5255W #microfluidics #biotechnology #medicaldevice #ivd #diagnostics

𝗔𝗹𝗴𝗶𝗻𝗮𝘁𝗲-𝗕𝗮𝘀𝗲𝗱 𝗘𝗹𝗲𝗰𝘁𝗿𝗼𝘀𝗽𝘂𝗻 𝗡𝗮𝗻𝗼𝗳𝗶𝗯𝗲𝗿𝘀 𝗮𝗻𝗱 𝘁𝗵𝗲 𝗘𝗻𝗮𝗯𝗹𝗲𝗱 𝗗𝗿𝘂𝗴 𝗖𝗼𝗻𝘁𝗿𝗼𝗹𝗹𝗲𝗱 𝗥𝗲𝗹𝗲𝗮𝘀𝗲 𝗣𝗿𝗼𝗳𝗶𝗹𝗲𝘀: 𝗔 𝗥𝗲𝘃𝗶𝗲𝘄 This paper reviews the development of alginate and electrostatic spinning technologies, and introduces the preparation of electrospun fibers with different structures by single-fluid, two-fluid, and multi-fluid. The electrospun alginate drug delivery system (EADDS) is also used to realize a variety of controlled release modes for different drugs, such as pulsatile release, sustained release, biphasic release, responsive release, and targeted release, to meet applications in various fields. #excipients #alginates #electrospinning

Doubts are common when innovation is in your hands! ✅ Our lipid nanoparticle reagents are easy to prepare by following simple steps without specific equipment. ✅ It is easy to select the right nanoparticle reagent as they have been optimized for each type of drug/biomolecule, which is disclosed in the name. Besides, we are well aware that doubts might arise, and we are happy to help. 👉🏽 For general doubts, check this link!  https://lnkd.in/dSn53qSm You can find frequently asked questions about our technology.  👉🏽 Find detailed use protocols by clicking on the specific products on our website.  https://lnkd.in/df_ebJFX 🤖 We keep improving our service and have launched a chatbot to help you answer any doubts. Don't find exactly what you are looking for? We are here to help. Contact us! info@diveresatechnologies.com #drugdelivery #nanotechnology #lipidnanoparticles #nanomedicine #biotechnology

😊 Welcome to read the Editor's choice paper: Current Advances in Stimuli-Responsive Hydrogels as Smart Drug Delivery Carriers by Yulong Zhang and Ben Wu, DDS PhD. 👇click here to download the full article: https://lnkd.in/dzaed-3A #smart_hydrogel #nanogel #drug_delivery #stimuli_responsive

Cell harvesting is crucial to the cell therapy manufacturing process, bridging the gap between cells’ optimized growth environment and a final formulation that retains their potency and efficacy. The number of variables that impact harvesting, coupled with the complexities introduced by the unique CQAs of each cell therapy and the fragility of many emerging cell types, can result in a challenging balancing act that requires significant expertise to navigate. Download the White Paper by Jacob Andrews here: https://hubs.ly/Q02l5gT50 #CARRBiosystems #biotechnology #allogeneic #celltherapy #bioprocessing

#Biotherapeutics are complex drugs that require careful manufacturing. This manufacturing all starts with the cell. Cell line development, and specifically #clone isolation and selection are one of the most critical steps to being successful. The most common techniques for single cell isolation are limiting dilution and #FACS, each with its own challenges. In this application note, we demonstrated the cold capture technique and how it can be combined with Bio-Techne´s #Pala single cell sorting to enable more efficient identification of high-producing clones. Get your copy of the application note here: https://lnkd.in/eUQn5c-E #clonality #celllinedevelopment #antibody