MicroGenDX’s Post

Exciting Discovery: How NGS Diagnosed Whipple’s Disease when other tests failed! Discover the power of Next Generation DNA Sequencing (NGS) in uncovering rare infections like Whipple’s Disease! Our latest case study showcases the remarkable clarity offered by MicroGenDX's qPCR + NGS testing, revealing Tropheryma whipplei when traditional tests fell short. Dive into the breakthrough here! https://loom.ly/jXU0F8Q 🔍 Patient's journey: An African-American female in her early 40’s saw her primary care physician (PCP) after suffering from several weeks of worsening dyspnea with cough and arthralgias. The patient underwent a bronchoscopy with bronchoalveolar lavage (BAL) and lung biopsy. The artifacts from these operations were subjected to a litany of medical tests, including: -Bronchoscopy with bronchoalveolar lavage (BAL) -BAL bacterial cultures -BAL acid-fast bacilli cultures -BAL fungal cultures -Aspergillus galactomannan of the BAL -BAL cytology for malignancy -BAL Pneumocystis jirovecii polymerase chain reaction (PCR) -Hypersensitivity pneumonitis panel -BAL pneumonia PCR panel -Lung biopsy Periodic acid-Schiff (PAS) stain However, a MicroGenDX NGS test exposed the presence of Tropheryma whipplei in the BAL sample. Furthermore, an EGD revealed chronically active Heliobacter gastritis and normal duodenal specimens with no evidence of T. whipplei. No MicroGenDX testing was used in the GI tract. Ready to experience the leading-edge in infectious disease testing? Order your qPCR + NGS test today! https://loom.ly/qf6fuUU #NGS #medicalinnovation #futureofmedicine #healthcare

I am continuously amazed by the transformative impact of next-generation sequencing (NGS) in medical diagnostics 🧬 This case study on #Whipple’sDisease underscores the precision and depth of NGS technology, highlighting its capability to uncover elusive pathogens when traditional methods fall short. The integration of #NGS into clinical practice not only advances our diagnostic accuracy but also paves the way for more personalized and effective patient care. Excited to see how this technology will shape the future of medicine! #Pulmonology #RespiratoryHealth #InfectiousDisease

Exciting Discovery: How NGS Diagnosed Whipple’s Disease when other tests failed! Discover the power of Next Generation DNA Sequencing (NGS) in uncovering rare infections like Whipple’s Disease! Our latest case study showcases the remarkable clarity offered by MicroGenDX's qPCR + NGS testing, revealing Tropheryma whipplei when traditional tests fell short. Dive into the breakthrough here! https://loom.ly/jXU0F8Q 🔍 Patient's journey: An African-American female in her early 40’s saw her primary care physician (PCP) after suffering from several weeks of worsening dyspnea with cough and arthralgias. The patient underwent a bronchoscopy with bronchoalveolar lavage (BAL) and lung biopsy. The artifacts from these operations were subjected to a litany of medical tests, including: -Bronchoscopy with bronchoalveolar lavage (BAL) -BAL bacterial cultures -BAL acid-fast bacilli cultures -BAL fungal cultures -Aspergillus galactomannan of the BAL -BAL cytology for malignancy -BAL Pneumocystis jirovecii polymerase chain reaction (PCR) -Hypersensitivity pneumonitis panel -BAL pneumonia PCR panel -Lung biopsy Periodic acid-Schiff (PAS) stain However, a MicroGenDX NGS test exposed the presence of Tropheryma whipplei in the BAL sample. Furthermore, an EGD revealed chronically active Heliobacter gastritis and normal duodenal specimens with no evidence of T. whipplei. No MicroGenDX testing was used in the GI tract. Ready to experience the leading-edge in infectious disease testing? Order your qPCR + NGS test today! https://loom.ly/qf6fuUU #NGS #medicalinnovation #futureofmedicine #healthcare

Dr Elizabeth Ballou from the Medical Research Council Centre for Medical Mycology (MRC CMM) working with Doctors Alyssa Hudson and Dora E Corzo León MD, PhD, have discovered that the monoclonal antibody TG11 is the first potential pan-Mucorales–specific antibody to detect active Mucorales growth! #Mucormycosis is a devastating #invasive #fungal disease affecting immunocompromised people and is acquired from the environment. Early and accurate diagnosis is essential, as untreated this fungus rapidly invades and destroys tissue. Infection is life altering and deadly so this research is hugely impactful. This important paper is just published in the Journal of Infectious Diseases and funded by Noah's Pink Balloon Leukaemia Fund https://lnkd.in/e_qaFNag #MRCCMM #fungalantimicrobialresistance #universityofexeter #amr #mucormycosis #bioimaging #medicalmycology #fungaldisese #fungalpathogens

Glad to share our recently published study in Inflammatory Bowel Diseases: https://lnkd.in/eFMAtyAC In this study, we applied high-dimensional analyses to profile the immune compartment in CD-associated and cryptoglandular perianal fistulas. Our analyses revealed that activated HLA-DR+CD38+ effector CD4+ T cells with a Th1/17 phenotype were significantly enriched in CD-associated perianal fistulas compared with cryptoglandular fistulas. These cells, displaying features of proliferation, regulation, and differentiation were also present in blood, and colocalized with other CD4+ T cells, CCR6+ B cells, and macrophages in fistula tracts. Targeting HLA-DR and CD38-expressing CD4+ T cells may offer a potential new therapeutic strategy for CD-associated fistulas. Many thanks to all co-authors for their contributions to this study! Ciska Lindelauf, Qinyue Jiang, Mette Schreurs, Tamim Abdelaal, Sietse Luk, Marieke Barnhoorn, Willem Hueting, Ingrid Han-Geurts, Koen Peeters, Fabian Holman, Frits Koning, Andrea van der Meulen, Maria Fernanda Pascutti

⏰ Only 3 days to the #LIVe2024 congress! ⏰ Session 8 of the LIVe 2024 congress will unveil ground breaking advancements in viral infection research. 🔬🫁    Traditional 2D cell culture models and animal models have limitations when translating findings to clinical applications.     At #LIVe2024, we will explore cutting-edge in vitro models that offer more human-relevant insights into viral pathogenesis.    We will:  🔹Delve into the application of human in vitro models for virology.  🔹Explore how inter-donor and inter-pool variability in 3D tissue models can be harnessed to optimize transcriptomic experimental design.  🔹Explore nebulized host-directed metabolic inhibitors for respiratory viral control.    This session is a must-attend for those seeking to stay at the forefront of viral infection research!  Head to https://lnkd.in/eHDD-nKV to check out the full program for the LIVe 2024 congress.   #LIVe2024 #3Rs #NAMs #invitro #viralinfections #research     📍Nice, France  📅June 20 -21     Our Sponsors: Epithelix HiLung Inc. Vitrocell Systems GmbH PKDERM STEMCELL Technologies emka TECHNOLOGIES FORMULATRIX PETA Science Consortium International e.V.

Tuberculosis (TB): What You Need to Know 🦠 Tuberculosis is caused by the Mycobacterium tuberculosis bacterium, primarily affecting the lungs, but it can impact other parts of the body like the kidneys, spine, and brain. While TB can be fatal, it’s often preventable and treatable. Early diagnosis is crucial. Ask your doctor to refer you to Lab24 for testing. #Biology #Health #Nursing #Cancer #Lab24 #Microscopy #PathologyLab #Healthcare #Cytopathology #Disease #Medicine #Microbiology #Hospital #PCR #Covid19 #Laboratory

An AFB (Acid-Fast Bacillus) smear is a laboratory test used to detect acid-fast bacteria, primarily Mycobacterium tuberculosis, the bacteria that causes tuberculosis (TB). Here's a brief overview: ### Purpose - **Diagnose Tuberculosis (TB):** Helps in the early detection of TB in patients. - **Monitor Treatment:** Assesses the effectiveness of TB treatment. ### Procedure 1. **Sample Collection:** Common samples include sputum, tissue, or other body fluids. 2. **Staining:** The sample is stained using a special dye (Ziehl-Neelsen or Kinyoun stain) that highlights acid-fast bacteria. 3. **Microscopy:** The stained sample is examined under a microscope for the presence of acid-fast bacilli. ### Interpretation - **Positive Result:** Indicates the presence of acid-fast bacilli; suggests TB or another mycobacterial infection. - **Negative Result:** No acid-fast bacilli detected, but does not completely rule out TB. ### Limitations - **Sensitivity:** May miss some cases of TB, especially in HIV-positive individuals. - **Specificity:** Cannot distinguish between different species of mycobacteria. ### Follow-Up - **Culture Tests:** Often performed alongside AFB smear for more accurate identification of mycobacteria. #MedicalLaboratoryTechnology #Microbiology #Phlebotomy #LaboratoryTesting #DiagnosticTesting #HealthcareProfessional #MedicalTesting #ClinicalLaboratory #BiomedicalScience #HealthcareIndustry #MedicalScience #LaboratoryMedicine #ClinicalMicrobiology #InfectionControl #PhlebotomyTechnician #MedicalLabTechnician #MicrobiologyLab #ClinicalLab #HealthcareCareer #MedicalCareer #ScienceCareer #COVID19Testing #Virology #Bacteriology #Parasitology #MolecularDiagnosis #GeneticTesting #Cytology #Histopathology #Immunology #Serology

The teams led by Stephen Murray (Steve Murray) and Phillip West (A. Phillip West) at JAX published for the first time a novel PolgR292C mouse model incorporating a deleterious patient mutation. Its inflammatory phenotype was compared to the PolgD257A mouse model (mutator mouse). Overall, this study provides important new insight into the innate immune mechanisms governing infection-related hyperinflammation in mouse models Polg MtD and furthers our understanding of why patients with MtD are more prone to developing sepsis and SIRS following infection. This opens-up new therapeutic venues targeting IFN-I and caspase-11 pathways to restore proper immune balance in the MtD population. To the article: Caspase-11 drives macrophage hyperinflammation in models of Polg-related mitochondrial disease https://lnkd.in/eDRjZHam #polg #mitochondria #mitodiseases #jax #jacksonlaboratory