Mihaela Patrascu’s Post

𝐴 𝑛𝑒𝑤 𝑏𝑟𝑎𝑖𝑛 ℎ𝑜𝑟𝑚𝑜𝑛𝑒 ℎ𝑎𝑠 𝑗𝑢𝑠𝑡 𝑏𝑒𝑒𝑛 𝑑𝑖𝑠𝑐𝑜𝑣𝑒𝑟𝑒𝑑 𝑖𝑛 𝑎𝑛𝑖𝑚𝑎𝑙𝑠. 𝐼𝑡 𝑐𝑜𝑢𝑙𝑑 ℎ𝑎𝑣𝑒 𝑎𝑝𝑝𝑙𝑖𝑐𝑎𝑡𝑖𝑜𝑛𝑠 𝑖𝑛 𝑣𝑎𝑟𝑖𝑜𝑢𝑠 𝑝𝑎𝑡ℎ𝑜𝑙𝑜𝑔𝑖𝑒𝑠 𝑟𝑒𝑞𝑢𝑖𝑟𝑖𝑛𝑔 𝑏𝑜𝑛𝑒 𝑠𝑜𝑙𝑖𝑑𝑖𝑓𝑖𝑐𝑎𝑡𝑖𝑜𝑛. 𝐹𝑜𝑐𝑢𝑠 𝑜𝑛 𝑚𝑎𝑡𝑒𝑟𝑛𝑎𝑙 𝑏𝑟𝑎𝑖𝑛 ℎ𝑜𝑟𝑚𝑜𝑛𝑒 ... 🦴 Osteoporosis affects around 200 million people worldwide. This medical condition is characterized by 𝐢𝐧𝐜𝐫𝐞𝐚𝐬𝐞𝐝 𝐛𝐨𝐧𝐞 𝐟𝐫𝐚𝐠𝐢𝐥𝐢𝐭𝐲, which can lead to fractures. It is particularly prevalent in women during the 𝐦𝐞𝐧𝐨𝐩𝐚𝐮𝐬𝐞, as estrogen production declines. This hormone is 𝐞𝐬𝐬𝐞𝐧𝐭𝐢𝐚𝐥 𝐟𝐨𝐫 𝐛𝐨𝐧𝐞 𝐩𝐫𝐨𝐝𝐮𝐜𝐭𝐢𝐨𝐧. However, its production also declines during breastfeeding, without increasing the risk of fractures. This was precisely the question that interested a team from San Diego. 🦴 These researchers recently published in 𝑁𝑎𝑡𝑢𝑟𝑒 the discovery of 𝐦𝐚𝐭𝐞𝐫𝐧𝐚𝐥 𝐛𝐫𝐚𝐢𝐧 𝐡𝐨𝐫𝐦𝐨𝐧𝐞 (CCN3) in animals. Their study showed that this hormone 𝐢𝐧𝐜𝐫𝐞𝐚𝐬𝐞𝐬 𝐛𝐨𝐧𝐞 𝐟𝐨𝐫𝐦𝐚𝐭𝐢𝐨𝐧 𝐛𝐲 𝐬𝐭𝐢𝐦𝐮𝐥𝐚𝐭𝐢𝐧𝐠 𝐛𝐨𝐧𝐞 𝐬𝐭𝐞𝐦 𝐜𝐞𝐥𝐥𝐬, in both young and old individuals. The researchers also investigated how CCN3 supplementation could be administered using a 𝐡𝐲𝐝𝐫𝐨𝐠𝐞𝐥 𝐩𝐚𝐭𝐜𝐡, with direct administration to a fracture, for example. The results in senior mice were promising. 🦴 Beyond osteoporosis, several populations and medical conditions may present an increased risk of fractures, such as women with 𝐛𝐫𝐞𝐚𝐬𝐭 𝐜𝐚𝐧𝐜𝐞𝐫 treated with hormone therapy, and 𝐲𝐨𝐮𝐧𝐠 𝐞𝐥𝐢𝐭𝐞 𝐚𝐭𝐡𝐥𝐞𝐭𝐞𝐬. #osteoporosis #hormone #ostéoporose #research #recherche #santé #health #medicine #médecine

𝐴 𝑛𝑒𝑤 𝑏𝑟𝑎𝑖𝑛 ℎ𝑜𝑟𝑚𝑜𝑛𝑒 ℎ𝑎𝑠 𝑗𝑢𝑠𝑡 𝑏𝑒𝑒𝑛 𝑑𝑖𝑠𝑐𝑜𝑣𝑒𝑟𝑒𝑑 𝑖𝑛 𝑎𝑛𝑖𝑚𝑎𝑙𝑠. 𝐼𝑡 𝑐𝑜𝑢𝑙𝑑 ℎ𝑎𝑣𝑒 𝑎𝑝𝑝𝑙𝑖𝑐𝑎𝑡𝑖𝑜𝑛𝑠 𝑖𝑛 𝑣𝑎𝑟𝑖𝑜𝑢𝑠 𝑝𝑎𝑡ℎ𝑜𝑙𝑜𝑔𝑖𝑒𝑠 𝑟𝑒𝑞𝑢𝑖𝑟𝑖𝑛𝑔 𝑏𝑜𝑛𝑒 𝑠𝑜𝑙𝑖𝑑𝑖𝑓𝑖𝑐𝑎𝑡𝑖𝑜𝑛. 𝐹𝑜𝑐𝑢𝑠 𝑜𝑛 𝑚𝑎𝑡𝑒𝑟𝑛𝑎𝑙 𝑏𝑟𝑎𝑖𝑛 ℎ𝑜𝑟𝑚𝑜𝑛𝑒 ... 🦴 Osteoporosis affects around 200 million people worldwide. This medical condition is characterized by 𝐢𝐧𝐜𝐫𝐞𝐚𝐬𝐞𝐝 𝐛𝐨𝐧𝐞 𝐟𝐫𝐚𝐠𝐢𝐥𝐢𝐭𝐲, which can lead to fractures. It is particularly prevalent in women during the 𝐦𝐞𝐧𝐨𝐩𝐚𝐮𝐬𝐞, as estrogen production declines. This hormone is 𝐞𝐬𝐬𝐞𝐧𝐭𝐢𝐚𝐥 𝐟𝐨𝐫 𝐛𝐨𝐧𝐞 𝐩𝐫𝐨𝐝𝐮𝐜𝐭𝐢𝐨𝐧. However, its production also declines during breastfeeding, without increasing the risk of fractures. This was precisely the question that interested a team from San Diego. 🦴 These researchers recently published in 𝑁𝑎𝑡𝑢𝑟𝑒 the discovery of 𝐦𝐚𝐭𝐞𝐫𝐧𝐚𝐥 𝐛𝐫𝐚𝐢𝐧 𝐡𝐨𝐫𝐦𝐨𝐧𝐞 (CCN3) in animals. Their study showed that this hormone 𝐢𝐧𝐜𝐫𝐞𝐚𝐬𝐞𝐬 𝐛𝐨𝐧𝐞 𝐟𝐨𝐫𝐦𝐚𝐭𝐢𝐨𝐧 𝐛𝐲 𝐬𝐭𝐢𝐦𝐮𝐥𝐚𝐭𝐢𝐧𝐠 𝐛𝐨𝐧𝐞 𝐬𝐭𝐞𝐦 𝐜𝐞𝐥𝐥𝐬, in both young and old individuals. The researchers also investigated how CCN3 supplementation could be administered using a 𝐡𝐲𝐝𝐫𝐨𝐠𝐞𝐥 𝐩𝐚𝐭𝐜𝐡, with direct administration to a fracture, for example. The results in senior mice were promising. 🦴 Beyond osteoporosis, several populations and medical conditions may present an increased risk of fractures, such as women with 𝐛𝐫𝐞𝐚𝐬𝐭 𝐜𝐚𝐧𝐜𝐞𝐫 treated with hormone therapy, and 𝐲𝐨𝐮𝐧𝐠 𝐞𝐥𝐢𝐭𝐞 𝐚𝐭𝐡𝐥𝐞𝐭𝐞𝐬. #osteoporosis #hormone #ostéoporose #research #recherche #santé #health #medicine #médecine

What is Alport Syndrome? A rare genetic kidney disease that affects the tiny filters in the kidneys (glomeruli), hindering their ability to remove waste products from the blood. Over time, this damage leads to progressive kidney failure. Types of Alport Syndrome: Two main types exist: -- Hereditary Alport Syndrome: Affects both males and females, inherited from a parent carrying the abnormal gene. -- X-linked Alport Syndrome: Primarily affects males due to a mutation on the X chromosome. Symptoms: Severity and age of onset determine symptoms, but early signs may include: -- Blood in the urine (hematuria) - a common first sign, often noticed in childhood. -- High blood pressure -- Frequent urination (polyuria) -- Hearing loss - progressive and may not be noticeable initially. Diagnosis and Treatment: Early diagnosis is crucial for managing the condition and slowing its progression. Diagnosis involves a combination of tests: Urinalysis Blood tests Genetic testing Kidney biopsy (if necessary) There is no cure, but treatment can help manage symptoms and slow kidney disease progression.  Options include: -- Blood pressure medications ACE inhibitors or ARBs to protect the kidneys -- Dietary changes -- Dialysis or kidney transplant in advanced cases While Alport Syndrome is rare, it highlights the importance of equal representation in clinical trials. Uncharted Access advocates for increased participation of Black, Latinx, and Asian/Pacific Islander communities in medical research. This ensures all populations benefit from advancements in treatments for Alport Syndrome and other rare diseases. #Healthcare #Healthcareworkers #alportawareness #clinicalresearchjobs #clinicaltrials #clinicalresearch

https://lnkd.in/gsbDqU5u Article title: Diabetic Retinopathy: Focus on Minority Populations   Author(s): Arpine Barsegian; Boleslav Kotlyar; Justin Lee; Moro O Salifu; Samy I McFarlane   Journal: International Journal of Clinical Endocrinology and Metabolism   Journal ISSN: 2640-7582 Abstract: Diabetic retinopathy is a major cause of blindness in the United States. With rise of the epidemic of obesity and diabetes in the USA and around the globe, serious and common diabetic complications are evolving as a major public health problem, particularly among minority populations. These populations are disproportionately affected by diabetes and 2-3 times more likely to develop visually significant complications. In this highly illustrated review article, we discuss the diabetic epidemic, highlighting the biology and the pathophysiologic mechanisms of this disorder on the anatomy of the eye. We also discuss the risk factors and the implications for minority populations. For the health care providers, we provide cutting edge information and imminently relevant information to help evaluate, manage, and know when to refer their patients to a specialist in ophthalmology to quell the tide of the epidemic. #EndocrineGlands #Hormones #HormoneMetabolism #StructureAndPhysiochemicalProperties #HormonalReceptors #SignalingMechanisms #HormoneRegulatedGeneExpression #IntracellularSteroidAndLipidMetabolism #BoneAndMineralMetabolism #Infertility #Peertechz #PeertechzPublications #SexualDifferentiation #Puberty #PediatricEndocrinology #EndocrinePharmacology #MolecularEndocrinology #GastrointestinalEndocrinology #Neuroendocrinology #ComparativeEndocrinology #CardiovascularEndocrinology #ReproductiveEndocrinology

What is Alport Syndrome? A rare genetic kidney disease that affects the tiny filters in the kidneys (glomeruli), hindering their ability to remove waste products from the blood. Over time, this damage leads to progressive kidney failure. Types of Alport Syndrome: Two main types exist: -- Hereditary Alport Syndrome: Affects both males and females, inherited from a parent carrying the abnormal gene. -- X-linked Alport Syndrome: Primarily affects males due to a mutation on the X chromosome. Symptoms: Severity and age of onset determine symptoms, but early signs may include: -- Blood in the urine (hematuria) - a common first sign, often noticed in childhood. -- High blood pressure -- Frequent urination (polyuria) -- Hearing loss - progressive and may not be noticeable initially. Diagnosis and Treatment: Early diagnosis is crucial for managing the condition and slowing its progression. Diagnosis involves a combination of tests: Urinalysis Blood tests Genetic testing Kidney biopsy (if necessary) There is no cure, but treatment can help manage symptoms and slow kidney disease progression.  Options include: -- Blood pressure medications ACE inhibitors or ARBs to protect the kidneys -- Dietary changes -- Dialysis or kidney transplant in advanced cases While Alport Syndrome is rare, it highlights the importance of equal representation in clinical trials. Uncharted Access advocates for increased participation of Black, Latinx, and Asian/Pacific Islander communities in medical research. This ensures all populations benefit from advancements in treatments for Alport Syndrome and other rare diseases. #Healthcare #Healthcareworkers #alportawareness #clinicalresearchjobs #clinicaltrials #clinicalresearch

🫀 📣 #AlCuoreDelDiabete Cardiorenal complications of diabetes are still the major cause of mortality and disability in people with diabetes, resulting in hospitalization in more than 75% of cases. In recent years, however, some diabetes drugs have demonstrated a significant reduction in cardiovascular and renal events in this disease (and in some cases even in patients without diabetes) as also recognized by EMA and AIFA. For this reason, international as well as national guidelines recommend their early use for the treatment of diabetes. Despite the numerous scientific evidences, poor interaction between specialists (both hospital and territorial) is probably one of the main reasons causing their non-use in clinical practice. The rationale of this course is, therefore, to deepen and update the current knowledge of prevention of complications of diabetes, with maximum interactivity between cardiologists, nephrologists and diabetologists. #congress #alcuoredeldiabete #unicatt #policlinicogemelli #rome #dm2 #ldl #trigliceridi #lpa #lipids #cardiology #diabetology #nephrology

Exciting to see the Society for Endocrinology and PeopleWith™ joining forces to develop the next generation of real-world data registries to advance understanding and optimise patient care. The collaboration between the Society for Endocrinology and PeopleWith™ to develop real-world data registries is exciting because it has the potential to improve our understanding of endocrine conditions, optimise patient care, and foster a more patient-centred and collaborative approach to healthcare. By harnessing the power of the patient's voice through PeopleWith™, the Society of Endocrinology will be able to: 1. Access comprehensive national databases of endocrine conditions 2. Empower Patients to manage their health 3. Access enhanced reporting with Patient-reported Outcome Measures (PROMs) 4. Advance research in endocrine care. They're starting off on a condition-by-condition basis, with specific configuration, and targeting over 30 endocrine conditions over the next ten years. Endocrinology is a branch of biology and medicine dealing with the endocrine system, its diseases, and its specific secretions known as hormones. It is also concerned with the integration of developmental events proliferation, growth, and differentiation, and the psychological or behavioural activities of metabolism, growth and development, tissue function, sleep, digestion, respiration, excretion, mood, stress, lactation, movement, reproduction, and sensory perception caused by hormones. Specializations include behavioural endocrinology and comparative endocrinology. Some of the most common types of endocrine disorders include:  Obesity Menopause   Diabetes   Addison’s disease  Cushing’s disease  Cancers of the endocrine glands The collaboration represents a pivotal moment and will help transform endocrine patient care. Looking forward to see the positive impact it will have for both healthcare professionals and patients alike. Read more: https://lnkd.in/eCXTVQrh #patientcare #dataregistries #realworlddata #endocrine #Endocrinology #Obesity #patientvoice #PROMs Mark Bradley Carys Richards Jessica Davis Image captured at #SfEBES2023

Osteoarthritis is the most common type of arthritis. It can be as a result of: 1. Primary cause: A primary cause is as a result of no known cause( Idiopathic), or as a result of family genetics. 2. Secondary cause: These are cause like ✓ Fractures ( intra articular fractures) ✓ Joint infections ✓ Joint instability ✓ Inflammatory Joint disorders ✓ Obesity As osteoarthritis progresses, bone changes occur depending on the stage of Osteoarthritis. They include: ✓ Decrease in bone density ✓ Articular cartilage becomes split and resolves down to the underlying bone ✓ The subchondral bone thickens ✓ Proliferation of new bone around the edges of the articular bone leading to formation of of spurs ✓ Capsules and ligaments become stiffened and painful. # Physical medicine and rehabilitation

Compared to GLP-1RAs and DPP4is, use of SGLT2is may lower the risk of nephrolithiasis in patients with type 2 diabetes, posing important implications for the use of glucose-lowering agents in this patient population, according to a new study from Julie Paik, MD, ScD, MPH, and colleagues. Learn more: https://lnkd.in/eNKHgsH6 #Nephrology #Type2Diabetes

Phenotype Development for Neonatal Hypoxic Ischemic Encephalopathy Using Electronic Health Record and Claims Datasets #OHDSISocialShowcase Lead: Star Liu Team: Tony Widenor, Danielle B., Gowtham A Rao MD PhD, Evan Minty, Khyzer Aziz Background: Hypoxic Ischemic Encephalopathy (HIE) is a type of brain injury among newborns. The incidence of HIE is 1.5-2.5 per 1000 live births in developed countries, and, among infants with HIE, 40-60% die by 2 years of age or develop severe disabilities. HIE occurs primarily due to acute perinatal asphyxia – a state where impaired cerebral blood flow and oxygen delivery to the brain result in decreased energy production, leading to cell death. Neonatologists and pediatricians are further challenged by the differential diagnosis of neonatal encephalopathy (2-6 per 1000 term births), of which HIE accounts for a portion of cases. Better clinical characterization, clinical phenotyping, and identification of subgroups most responsive to existing therapies for patients with HIE could potentially lower the risk of adverse neurodevelopmental outcomes. The objective was to develop a phenotype for HIE and assess the algorithm using Observational Medical Outcomes Partnership (#OMOP) Common Data Model (CDM) datasets and tools. #JoinTheJourney https://lnkd.in/eDkAxiaQ