Mohamed Haitham Ayad’s Post

🔬 One important aspect of fully comprehending tumors is understanding their metabolism. #Cancer cells undergo metabolic modifications to meet high bioenergetic and anabolic demand during tumorigenesis. 🔎 Monitoring metabolite dynamics and lactate production in physiologically relevant patient-derived models can provide valuable data for understanding metabolic perturbations during disease progression, #drug response and resistance. ✨ We demonstrate an automated workflow using the #pumasystem to assess metabolic changes in triple negative breast cancer (TNBC) #tumoroids in response to treatment with anti-cancer drugs. 💡 Learn more: https://lnkd.in/gu7mCNPS 

The effects of adding palbociclib to endocrine therapy to treat advanced breast cancer: a plain language summary of a study using the PALOMA-2 and PALOMA-3 trial results. Read more 👉 https://lttr.ai/APJ2L #Cdk46Inhibitor #AromataseInhibitors #HormoneReceptorPositive #Pharmacist #Healthcare #Quality #Chemotherapy #GenomicComplexityDetected #BloodCopyNumberBurden #PredictPoorOutcomes

Regorafenib has shown efficacy in treating colorectal cancer patients. However, its use is limited by the absence of predictive biomarkers and concerns about toxicity. Learn how this study utilized the Incucyte®️ live cell analysis platform to measure 3D spheroid migration and tube formation using the Huvec-PDO co-culture assay, identifying MIR652-3p as a clinical biomarker and a new tool for patient selection. Discover more: https://ow.ly/9sOX50RHZMm #cancerresearch #colorectalcancer #biomarkers #incucyte #livecellanalysis

👏 We are excited to announce that AmoyDx® Pan Lung Cancer PCR Panel has been approved by the Japanese Ministry of Health, Labour and Welfare (MHLW) as a companion diagnostic for TABRECTA™ (capmatinib) – designed for patients with unresectable, advanced, or recurrent non-small cell lung cancer (NSCLC) with MET exon 14 (METex14) skipping alterations. 🎆 The AmoyDx PLC Panel detects alterations across 11 critical driver genes and identifies actionable mutations in seven of these genes which are directly linked to twelve targeted NSCLC therapies. This approval marks a significant advancement in precision cancer treatment with the potential to significantly enhance patient outcomes. Read the full press release here 👉 : https://lnkd.in/g9BRamEn #PrecisionMedicine #Oncology #NSCLC #LungCancer #Cancer

This post hoc analysis delves into the relationship between weight gain during first-line platinum-based chemotherapy & overall survival in advanced non-small cell lung cancer (NSCLC) patients. By examining data from three phase III clinical studies, the study provides valuable insights into the potential impact of weight fluctuations on treatment outcomes. Understanding these dynamics is essential for refining therapeutic approaches in NSCLC management. https://lnkd.in/g2mP-6wW #NSCLC #Chemotherapy #Survival #Research #SCWD #Oncology #ClinicalResearch #MedicalScience #PatientOutcomes #HealthcareManagement #CancerResearch #ScientificStudy #ClinicalTrials #EricRoeland #FlorianFintelmann #FionaHilton #RuoyongYang #EdWhalen #LisaTarasenko #RobertoCalle #PhilipBonomi

The radioactive lutetium-177 payload emits beta radiation which disrupts cancer cell DNA, causing cell death and tumor regression. Read more 👉 https://lttr.ai/AW7iX #Pharmacist #Healthcare #Quality #Chemotherapy #ProstateSpecificMembraneAntigen #CausingCellDeath #ClinicalTrialsRelated #StudySPatientPopulation #VarySubstantiallyDepending #ProvideDefinitiveConclusions

Regorafenib has shown efficacy in treating colorectal cancer patients. However, its use is limited by the absence of predictive biomarkers and concerns about toxicity. Learn how this study utilized the Incucyte®️ live cell analysis platform to measure 3D spheroid migration and tube formation using the Huvec-PDO co-culture assay, identifying MIR652-3p as a clinical biomarker and a new tool for patient selection. Discover more: https://ow.ly/9sOX50RHZMm #cancerresearch #colorectalcancer #biomarkers #incucyte #livecellanalysis

Dear Researchers, Are you keen to understand the specific mechanisms by which Regorafenib exerts its effects on colorectal cancer cells? The use of 3D spheroid assays has been increasingly recognized for its ability to mimic the tumor microenvironment more accurately than traditional 2D cultures. Our Live cell imaging, Incucyte® from Sartorius offers a dynamic view of cellular processes in real time, providing valuable insights that static assays cannot. Please access the below link to understand further: #colorectalcancer #livecellanalysis #incucyte #spheroid #3dspheroids #cellculture #smallmolecules

#CABS24 is running at full speed 🚀. Catch up with our Co-founders Barna Gal, MD, and Chris Steffi to see how our 3D in vitro bone models can facilitate research and clinical decision making in the field of #CIBD Cancer Induced Bone Disease! #BoneOrganoids #BoneHealth #3DInVitroModels #BoneResearch #BoneMetastases #BoneCancer #Osteosarcoma #BreastCancer #ProstateCancer #LungCancer #RenalCancer

How might my biomarkers be tested? Biomarkers can be tested for in biopsies or in blood. It is important to test for biomarkers as soon as treatment is being considered. Every stomach cancer is unique, and testing early for your cancer’s specific biomarkers ensures that you and your healthcare team can identify the very best personalized treatment options – now and in the future.