Mohammad Vaziri’s Post

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Thoracic Surgery Professional - Researcher -Educator-Peer Reviewer

#cancerresearch #genetics #oncology #mutations https://lnkd.in/gQAeA297 Abstract The RAF family of #kinases includes key activators of the pro-tumourigenic mitogen-activated protein kinase pathway. Hyperactivation of #RAF #proteins, particularly BRAF and CRAF, drives #tumour #progression and drug resistance in many types of cancer. Although BRAF is the most studied RAF protein, partially owing to its high mutation incidence in melanoma, the role of CRAF in tumourigenesis and drug resistance is becoming increasingly clinically relevant. Here, we summarize the main known regulatory mechanisms and gene alterations that contribute to CRAF activity, highlighting the different oncogenic roles of CRAF, and categorize RAF1 (CRAF) mutations according to the effect on kinase activity. Additionally, we emphasize the effect that CRAF alterations may have on drug resistance and how precision therapies could effectively target CRAF-dependent tumours. Here, we discuss preclinical and clinical findings that may lead to improved treatments for all types of oncogenic RAF1 alterations in cancer.

The role of CRAF in cancer progression: from molecular mechanisms to precision therapies - Nature Reviews Cancer

The role of CRAF in cancer progression: from molecular mechanisms to precision therapies - Nature Reviews Cancer

nature.com

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