Mohsen Hojat’s Post

#ACC24: REDUCE-AMI Read this joint review ✍ by Nicola Ryan & Ali Nazmi Çalık of this multicentre, registry-based, prospective open-label parallel-group trial evaluating the benefit of beta-blocker treatment in patients with acute MI and an ejection fraction >50% treated with a contemporary reperfusion strategy. 🔗 https://lnkd.in/dpNmBiPP #heartfailure #interventionalcardiology #clinicaltrial #cardiologist

The sometimes competing needs and dynamics at play when patients are searching for answers and guidance: "Medicine does not like elusiveness and subjectivity, so doctors in conversation with patients often direct them to what is measurable and objective (statistics, treatment regimens, etc)." Though a small study, this is a fascinating read on the professional, social and emotional dynamics of physicians who become oncology patients: https://lnkd.in/gs7uEZP9 Chmielewska-Ignatowicz et al (2024) shed light on the mental models that the practice of medicine has instilled in physicians that they may take to their own role as an oncology patient. A conclusion: "The need to assuage anxiety and maintain hope, to build a proper relationship with an attending physician guiding the entire treatment process, and the need to put common knowledge over scientific knowledge—however, trivial it may sound—indicates that, when confronted with cancer, a doctor-patient has the same strong emotional needs as the patient who is not a doctor." #PatientEducation #CME #Medsoc

We are proud to share our latest publication in Cardiovascular Revascularization Medicine, titled "A stratified pathway to stent-free reperfusion: Selecting suitable patients in ST-elevation myocardial infarction." This study explores the feasibility of individualized reperfusion strategies in real-world settings, raising critical questions for future research. Nos enorgullece compartir nuestra última publicación en Cardiovascular Revascularization Medicine, titulada "Un camino estratificado hacia la reperfusión sin stent." Este estudio analiza la viabilidad de estrategias de reperfusión individualizadas en entornos clínicos reales. Nous sommes fiers de partager notre dernière publication dans Cardiovascular Revascularization Medicine, intitulée "Une approche stratifiée pour une reperfusion sans stent."

Our Editorial in the journal of American College of Cardiology on ARNI in hospitalized patients. Clinical Pharmacists can help optimize therapy by knowing that: - Overall Inertia relating to GDMT initiation is a real-world phenomenon - Guidelines emphasize the importance of GDMT initiation after achieving clinical stability during HF hospitalizations and highlights the need to reinitiate and titrate medications up to target dose after any discontinuation - Patients who are initiated on GDMT before discharge are more likely to maintain these therapies and to get titrated to target doses following discharge https://lnkd.in/dDvJiqTt

Up to 50–60% of patients with episodes of chest pain suggesting stable angina and about 15% of patients admitted to hospital with a clinical diagnosis of non-ST-segment elevation acute coronary syndrome (NSTE-ACS) are found to have non-obstructive coronary artery disease (NO-CAD) at angiography.   In a proportion of both groups, the intracoronary acetylcholine (Ach) provocation test induces epicardial coronary artery spasm (CAS) or coronary microvascular spasm (CMVS), but their causal role in individual patients is not always clear.   The findings of this our study suggest caution in attributing to the results of Ach testing a definite causal role for the clinical syndrome in these patients.   Thanks to Prof. Lanza for being a wise and patient guide. Fondazione Policlinico Universitario Agostino Gemelli IRCCS Università Cattolica del Sacro Cuore Journal of Clinical Medicine (JCM) MDPI https://lnkd.in/eCAS6ay3

Recently, Pharmacy Times highlighted key findings from a study conducted at Erasmus MC Hospital in Rotterdam, Netherlands evaluating neurofilament light chain (NfL) in #GuillainBarreSyndrome (GBS). The study shows that higher levels of NfL in blood are strongly linked to more severe nerve damage and slower recovery, making it a useful tool for predicting how GBS might affect a patient. The study also suggests that serum NfL could be used to monitor the effectiveness of treatments. This is the largest study cohort to-date evaluating NfL serum levels in GBS patients and supports many of the findings we have seen at Annexon Biosciences.     GBS is a neurological emergency that requires quick and targeted treatment to stop the ongoing nerve damage, help patients getting better sooner and achieve better outcomes over the long-term. While there is more to learn about the role of NfL in GBS and other diseases causing peripheral nerve damage, this study and ongoing work at Annexon are hugely important to bring more effective GBS treatments to patients around the world. You can learn more by reading the full article from Pharmacy Times here: https://lnkd.in/gctAXDpd

📍New in Journal of Cardiovascular Electrophysiology 📖Adjunctive low-voltage area ablation for patients with atrial fibrillation: An updated meta-analysis of randomized controlled trials by Rivera A et al ➡️ In this systematic review and meta-analysis of RCTs, adjunctive low-voltage area ablation reduced atrial tachyarrhythmia recurrence and the need for redo procedures in patients with #AFib undergoing catheter ablation. https://lnkd.in/d3VUTXiP bradley knightHawkins Gay, MD, MPH, MSAI Giacomo Mugnai Graham Peigh #EPeeps

There is an abundance of evidence-based research that supports exercise as an intervention in the oncology setting throughout the entire cancer care continuum; however, exercise or physical activity initiatives are not standard of care in oncology practice. There is a great need to implement exercise oncology research into practice in order to improve treatment toleration, quality of life and overall patient outcomes. Many times the hard part may be knowing where to start. Fight The Fatigue® has created a beginner guide to a progressive 10 week cardio program that may be used as a guide/reference to #movemoresitless! Please, DOWNLOAD, USE, SHARE, LIKE! Fight The Fatigue® provides personalized, safe and effective cancer exercise programs and continuing education courses for nurses about exercise oncology. My mission is to improve physical, mental and emotional health and well being in order for those living with cancer to maintain independence, mitigate treatment-related side effects and improve quality of life.

Improving outcomes after post–cardiac arrest brain injury, ILCOR scientific statement 🧠 post CA brain injury mechanisms ⛔️ challenges in translating preclinical research to clinical practice & therapeutic interventions which failed to improved outcomes in clinical trials 🚧 prioritization of barriers to discovery/translation of neuroprotective therapies for post CA BI #FOAMcc 🔓 https://bit.ly/3VMioOU

#Spinal cord injuries (SCIs) are complex medical conditions resulting from spinal cord damage, often caused by #trauma, as in motor vehicular crashes and falls, and nontraumatic aetiologies like malignancy and degeneration. Spinal cord lesions may result in severe morbidity and permanent disability. High spinal lesions are often a cause for emergency due to cardiorespiratory compromise. The #pathologic mechanisms causing #SCIs are classified as either primary or secondary. Primary injury, often irreversible, arises from direct spinal cord damage. Secondary injury occurs as a consequence of the changes induced by a primary injury, such as #inflammation. #Nerve #axon disruption produces motor and sensory function loss below the level of injury. The diagnosis depends on a combination of clinical examination and diagnostic testing, particularly imaging studies. Treatment options include conservative, operative, rehabilitative, or a combination of these modalities. Novel interventions like stem cell therapy are still under investigation. This activity for healthcare workers is designed to enhance learners' proficiency in evaluating and managing SCIs. After participation, learners strengthen their skills in utilizing best practice guidelines, implementing emergency measures, and seeking consults within the appropriate timeframes. Participants heighten their diagnostic and management acumen, enabling them to collaborate effectively within an interprofessional team seeking to improve outcomes for individuals with SCIs. https://lnkd.in/eQ_Ci6XA