Maple Syrup Urine Disease (MSUD) Family Support Group’s Post

Unlocking the Secrets of Aging: The Role of Epigenetics in Cellular Senescence 🧬🔍 💡 Discover the pivotal role of epigenetics in regulating gene expression and its impact on aging processes. 💡 Gain insights into potential therapeutic avenues for combating age-related diseases. 💡Explore cutting-edge research unraveling the mechanisms governing cellular aging. 🔗 Read the full blog here: https://bit.ly/3TPgzRr #Aging #Epigenetics #CellularSenescence #DNA

#multiomicspapers challenge! https://lnkd.in/dwdguNYq Many thanks Vivek Das, PhD, M.Sc. Das, PhD, M.Sc. for sharing this insightful post about SGL2i and diseases! 🔥🔥🔥💡 I am really excited to explore the connection of these type of drugs with lifespan and aging. What is the the potential mechanism behind the effect? Could it be through the regulation of Sirtuins? An exciting example of bridging epigenetic mechanisms. HDACs and gene regulation? #multiomics on 🔥!!! The idea of using aging clocks to monitor these effects is also thought-provoking and adds to the discussion. M. Austin Argentieri Olink Proteomics I look forward to reading more about this topic and hearing your thoughts on this in the comments. #SGLT2i #AntiAging #Epigenetics

Exciting breakthrough in gene regulation and epigenetics! Researchers have developed an innovative epigenome editing platform, revolutionizing our understanding of how genes are controlled. By employing CRISPR technology, they can precisely program epigenetic modifications across the genome, shedding light on new mechanisms of gene expression. This discovery not only deepens our knowledge but also holds immense promise for personalized medicine. Read more about this groundbreaking study and its implications for the future of healthcare. #MentalHealthAwarenessMonth #MosaicBiodata Read the full article: https://lnkd.in/ds_Ad86k

𝐂𝐨𝐧𝐠𝐫𝐚𝐭𝐮𝐥𝐚𝐭𝐢𝐨𝐧𝐬 𝐭𝐨 𝐭𝐡𝐞 𝟐𝟎𝟐𝟒 𝐍𝐨𝐛𝐞𝐥 𝐏𝐫𝐢𝐳𝐞 𝐢𝐧 𝐌𝐞𝐝𝐢𝐜𝐢𝐧𝐞 𝐖𝐢𝐧𝐧𝐞𝐫𝐬!   We want to celebrate the 𝗿𝗲𝗺𝗮𝗿𝗸𝗮𝗯𝗹𝗲 𝗮𝗰𝗵𝗶𝗲𝘃𝗲𝗺𝗲𝗻𝘁 of Victor Ambros and Gary Ruvkun who were jointly awarded the prestigious 2024 Nobel Prize for Medicine. The award was for their discovery of 𝗺𝗶𝗰𝗿𝗼𝗥𝗡𝗔 𝗮𝗻𝗱 𝗶𝘁𝘀 𝗿𝗼𝗹𝗲 𝗶𝗻 𝗽𝗼𝘀𝘁-𝘁𝗿𝗮𝗻𝘀𝗰𝗿𝗶𝗽𝘁𝗶𝗼𝗻𝗮𝗹 𝗴𝗲𝗻𝗲 𝗿𝗲𝗴𝘂𝗹𝗮𝘁𝗶𝗼𝗻. Their discoveries have paved the way for innovation, especially in gene activity, and continue to shape the future. We are inspired by their dedication and the 𝘁𝗿𝗮𝗻𝘀𝗳𝗼𝗿𝗺𝗮𝘁𝗶𝘃𝗲 𝗶𝗺𝗽𝗮𝗰𝘁 𝗥𝗡𝗔 𝘁𝗲𝗰𝗵𝗻𝗼𝗹𝗼𝗴𝗶𝗲𝘀 are having on global health care. etherna was founded over 10 years ago to bring mRNA-based medicines to market. We are thrilled to see the attention that mRNA is being focussed on this field especially as this marks 𝘁𝗵𝗲 𝘀𝗲𝗰𝗼𝗻𝗱 𝗰𝗼𝗻𝘀𝗲𝗰𝘂𝘁𝗶𝘃𝗲 𝘆𝗲𝗮𝗿 that the Nobel Prize for Medicine 𝗿𝗲𝗰𝗼𝗴𝗻𝗶𝘇𝗲𝘀 𝘁𝗵𝗲 𝗶𝗻𝗰𝗿𝗲𝗱𝗶𝗯𝗹𝗲 𝗽𝗼𝘁𝗲𝗻𝘁𝗶𝗮𝗹 𝗼𝗳 𝗥𝗡𝗔-𝗯𝗮𝘀𝗲𝗱 𝗿𝗲𝘀𝗲𝗮𝗿𝗰𝗵. #NobelPrize #NobelPrize2024 #RNAResearch #RNAtherapeutics #Innovation

DNA methylation plays a crucial role in gene regulation and adaptation in Daphnia magna. A recent study using whole genome bisulfite sequencing revealed that DNA methylation in D. magna predominantly targets 5' exons downstream of transcription start sites. These findings provide insights into the epigenetic mechanisms underlying gene expression and evolution in this model organism. #DaphniaMagna #DNAMethylation #GeneRegulation #Epigenetics #EvolutionaryStudies Read more here: https://lnkd.in/eUxsNT4m BioMedHack.com is your leading source for the latest news, breakthroughs, and insights in medicine, biohacking, and alternative medicine. Our mission is to help you live healthier and longer by bringing you cutting-edge information and expert advice. Follow us on Facebook, Instagram, and X.

✂ Can we treat neurological diseases with a gene editing approach? 🧠✂ In this DNA Today episode, Julien Valton Ph. D, presents the development of an intron-specific gene insertion strategy for HSPC, that could enable the development of efficient therapies for both metabolic and neurological disorders. + More on comparison of TALEN® with other gene editing technologies like CRISPR. + Specific diseases targeted with TALEN® in the near future 🎥 https://lnkd.in/eDxpQJ3J #celltherapy #genetherapy

We continue with Christine Galustian 's exciting article: CAN MUTATIONS GIVE YOU SUPERPOWERS?! Pain Insensitivity Mutations in the positive regulatory domain I-binding factor 1 (PRDM12 gene), Neurotrophic Tyrosine-Kinase receptor (NTRK1 gene), and SCN9A genes cause congenital (inherited at birth) insensitivity to pain (CIP). SCN9A encodes (results in the production of) the protein controlling the voltage-gated sodium channel protein Nav 1.7. and PRDM12 encodes a regulator of sensory neurons, the PR domain zinc finger protein 12: Both proteins are found in pain-sensing nerve cells. The NTRK1 gene codes for a protein that sends pain and temperature signals to the brain. People with CIP don't feel pain and cannot detect high temperatures, which can be both a blessing and a curse. Individuals with this mutation must be vigilant about injuries and other health issues. #superpower #superpowers #painsensitivity #hookelondon #genetics #longevity #sciencecommunication #healthresearch #nervecells #cellmutation #superhuman #mutations

The 2024 Nobel Prize in Physiology or Medicine celebrates the groundbreaking discovery of microRNA's role in gene regulation by Victor Ambros and Gary Ruvkun. Their work has inspired new approaches to gene therapies and genome manipulation, with potential applications in treating genetic disorders and other diseases. Learn more about these advancements and their impact on biotechnology, as well as insights into intellectual property strategies for RNA technologies. Check out the full article by Julia Hornig, PhD here: https://lnkd.in/ej6usCZ7

Life-extension research is evolving rapidly, with technologies like CRISPR and gene therapy leading the charge. However, small molecules offer a unique advantage by targeting multiple therapeutic sites simultaneously. This polypharmacological approach is key to addressing the complex challenges of aging and chronic diseases. A recent preprint, "𝐌𝐮𝐥𝐭𝐢𝐩𝐥𝐞 𝐓𝐚𝐫𝐠𝐞𝐭𝐬, 𝐎𝐧𝐞 𝐆𝐨𝐚𝐥: 𝐂𝐨𝐦𝐩𝐨𝐮𝐧𝐝𝐢𝐧𝐠 𝐋𝐢𝐟𝐞-𝐄𝐱𝐭𝐞𝐧𝐬𝐢𝐨𝐧 𝐄𝐟𝐟𝐞𝐜𝐭𝐬 𝐨𝐟 𝐒𝐦𝐚𝐥𝐥 𝐌𝐨𝐥𝐞𝐜𝐮𝐥𝐞 𝐃𝐫𝐮𝐠𝐬 𝐛𝐲 𝐏𝐨𝐥𝐲𝐩𝐡𝐚𝐫𝐦𝐚𝐜𝐨𝐥𝐨𝐠𝐲," highlights groundbreaking research in this field. Using AI and machine learning, researchers identified compounds that significantly extend lifespan by targeting multiple biogenic amine receptors. 𝐎𝐯𝐞𝐫 70% 𝐨𝐟 𝐭𝐡𝐞𝐬𝐞 𝐜𝐨𝐦𝐩𝐨𝐮𝐧𝐝𝐬 𝐫𝐚𝐧𝐤 𝐢𝐧 𝐭𝐡𝐞 𝐭𝐨𝐩 5% 𝐨𝐟 𝐞𝐟𝐟𝐢𝐜𝐚𝐜𝐲 𝐚𝐜𝐜𝐨𝐫𝐝𝐢𝐧𝐠 𝐭𝐨 𝐭𝐡𝐞 𝐃𝐫𝐮𝐠𝐀𝐠𝐞 𝐝𝐚𝐭𝐚𝐛𝐚𝐬𝐞. Join us at Healthcare Innovators Connect, our exclusive gathering where we discuss and drive innovation in healthcare. Message me for an invite to our next session and be part of the conversation transforming patient care. #HealthcareInnovation #DrivePatientCare #HealthcareInnovatorsConnect #IPTLfromSingapore

Just published: work by Michael Waters, MD, PhD, & Jin Zhang, PhD, MPHS, using #GenerativeAI to improve gene expression analysis where there are limited samples, as in rare diseases, minority populations or limited resources. https://bit.ly/3tIAibj #NCIITCR #cancerresearch #cancerbiology