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Sucralfate Sucralfate forms a protective coat and protects the gastric mucosa from pepsin, pectic acid, and bile salts. This drug binds to positively charged proteins in exudates, locally forming a thick viscous substance. Brands available Ulsanic Surlka Ulcocid Mechanism of Action Sucralfate prevents hydrolysis by preventing the enzyme-substrate complex formation. This drug adsorbs pepsin and decreases its concentration. Clinical uses Sucralfate is a drug used to treat various medical conditions including duodenal ulcers, epithelial wounds, chemotherapy-induced mucositis Radiation proctitis Ulcers in Behçet disease.