NanoSphere’s Post

🌟 Exciting News! 🌟   We are thrilled to announce that our expertise in custom peptide synthesis has been recognized once again! 🎉   We are honored to have been cited as a trusted supplier of micropeptides in a recent article published by MDPI. The article explores the role of micropeptides in various biological processes, shedding light on their potential applications in research and therapeutics. From understanding cellular signaling pathways to developing novel therapies, micropeptides hold immense promise in advancing scientific discoveries.   Check out the article here: https://lnkd.in/dWj5qCc5   At SB-PEPTIDE, we strive to provide tailored solutions to researchers and professionals worldwide. Whether you're in need of micropeptides or any other custom peptides, we've got you covered!   Explore our 10 days express synthesis service and experience the convenience of rapid peptide synthesis for your research projects: https://lnkd.in/eiz-BXv   Thank you to our team for their hard work and dedication, and to the researchers who trusted us as their peptide synthesis partner. We look forward to supporting more innovative projects in the field of peptide science.   Drop a thumb if you liked this post and stay tuned for more outbreaking news !   #PeptideSynthesis #Micropeptides #CustomPeptides #Research #Innovation #MDPI #Science #Biotechnology

Missed this opportunity to hear Dr. Victoria Conlin & Danny Leung present applications for intestinal #Organoids for #DrugDiscovery? You can now watch this webinar with STEMCELL Technologies on-demand, here 👇 https://bit.ly/49wvFAA Discover applications of intestinal organoid cultures in: ☑️ Drug discovery, including how organoid-derived intestinal cell cultures can be applied to assess the toxicity of potential therapeutic compounds ☑️ Modeling barrier function #Intestine #GutResearch #DrugDevelopment

Explore our human M1/M2 macrophage polarization in vitro assay. A well-defined in vitro model to test the effect of drug-candidates on the M1/M2 balance!

Exciting times not just for out BD team, but also all of you looking to get the most data from your precious cells--combine your single-cell profiling of intracellular proteins, surface proteins and RNA all in one experiment! Fully supported by our single cell team, you can finally have that truly multiomic study that fits your needs without the risk of sample loss or bias. Ready to design your next experiment together? #singlecell #CITEseq #singlecellmultiomics #RNAseq #morecellslessnoise

Innovative cell lines from BPS Bioscience Inc. enable #DrugDiscovery Simplify biological readouts using #luciferase reporter #celllines. Upon engagement with a ligand of interest, these sensitive reporter #cells will produce #firefly luciferase, which can be measured using BPS' ONE-Step™ Luciferase Assay System. The cells are suitable for use in #highthroughput systems to screen for #inhibitors or #agonists. ➡ Cell Lines from BPS Bioscience: https://lnkd.in/eEbCCPeK ➡ ONE-Step™ Luciferase Assay System: https://lnkd.in/eiaXRTrk Discover the large portfolio of over 80 reporter cell lines with many novel products covering a wide array of #research areas, including cells expressing glucagon receptor (GCGR), thyroid hormone receptor beta (TRβ), the TL1A receptor DR3, GLP-1R, GIPR, and CGRPR. Optimized Thaw, Growth, and Assay media are also available. You would like to test products and save on your research budgets? Most of the reporter cell lines by BPS Bioscience qualify for the 3 month rental program at 50% of list cost. Learn more here: https://lnkd.in/enk7B5UA #biomol #bpsbioscience #youhavethevisionwehavethesubstance

A snippet from the last issue! 🙌 Better modifications for nucleotides: Modified nucleotides are increasingly used in biotech and therapeutics (the Covid vaccine anyone?). But making them is not easy: so, this study presents a new method for synthesizing chemically modified oligonucleotides using template-dependent DNA ligation with T3 DNA ligase. It offers improved scalability and flexibility, producing oligonucleotides of varying lengths (20–120 nucleotides) and tolerating diverse modifications. #synbio #molecularbiology #drugdelivery Read and subscribe at the link in bio!

Drug development is challenging – a lot of drugs in development don’t make it to market. Limited reliability of biomarker data can be one of many struggles that drug developers face. In this clip, Ernestas Sirka, Chief Scientific Officer at Inoviv, describes how they address common challenges to drug development success. One innovative solution is combining Immunoprecipitation with Mass Spectrometry (IP-MS). Discover how the groundbreaking NeuroKey-3™ assay is accelerating neurodegenerative drug discovery and development in the full webinar, available on-demand: https://hubs.li/Q02zkVc_0 #Proteomics #MassSpec #DrugDiscovery #DrugDevelopment #AlzheimersDisease #BiotechWebinar

IBA Lifesciences is a valued U.S. partner of Neuromics (https://lnkd.in/duB9beQk). These tools are used for protein and antibody selection, purification, and expansion. They have proven over and over again to work in the hands of our users. As an example, researchers used IBA's Strep-Tactin superflow cartridge to select and purify the Strep-tag11-CUL-2 protein ("a target for novel therapeutics")-https://lnkd.in/gmq5eS8M We will routinely update you on these tools' novel and emerging applications. Lisa Held IBA Lifesciences Neuromics David Rupp #proteinpurification #proteinengineering #proteinresearch #proteinexpression

Identifying pharmacological probes for human proteins represents a key opportunity to accelerate the discovery of new therapeutics. High-content screening approaches to expand the ligandable proteome offer the potential to expedite the discovery of novel chemical probes to study protein function. While screening libraries of reactive fragments by chemoproteomics offers a compelling approach to ligand discovery, optimising sample throughput, proteomic depth, and data reproducibility remains a key challenge. The publication reports versatile, label-free quantification proteomics platform for competitive profiling of cysteine-reactive fragments against the native proteome Upon screening 80 reactive fragments in two cell lines identifying >400 ligand-protein interactions, hits were validated through concentration-response experiments and the platform was utilised for hit expansion and live cell experiments. This label-free platform represents a significant step forward in high-throughput proteomics to evaluate ligandability of cysteines across the human proteome. https://lnkd.in/gw8ids5q