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#LipidNanoparticles, #RNATherapeutics, #QualityAssessment | 𝗛𝗼𝘄 𝗰𝗿𝗶𝘁𝗶𝗰𝗮𝗹 𝗶𝘀 𝘁𝗵𝗲 𝗿𝗼𝗹𝗲 𝗼𝗳 𝗿𝗼𝗯𝘂𝘀𝘁 𝗮𝗻𝗮𝗹𝘆𝘁𝗶𝗰𝗮𝗹 𝗺𝗲𝘁𝗵𝗼𝗱𝘀 𝗶𝗻 𝘁𝗵𝗲 𝗱𝗲𝘃𝗲𝗹𝗼𝗽𝗺𝗲𝗻𝘁 𝗼𝗳 𝗶𝗻𝗻𝗼𝘃𝗮𝘁𝗶𝘃𝗲 𝗥𝗡𝗔 𝘁𝗵𝗲𝗿𝗮𝗽𝗶𝗲𝘀? 🟣 𝗔𝗶𝗺 To assess the quality of lipid nanoparticles (LNPs) used for in-vivo intracellular delivery of nucleic acids through comprehensive analytical methods. 🟣 𝗞𝗲𝘆 𝗙𝗶𝗻𝗱𝗶𝗻𝗴𝘀 Evaluation and comparison of analytical protocols for chemical composition, drug loading, particle size, concentration, and stability. Assessment of measurement protocols for reproducibility, robustness, and correlative approaches. 🟣 𝗧𝗮𝗸𝗲 𝗛𝗼𝗺𝗲 𝗠𝗲𝘀𝘀𝗮𝗴𝗲 This research highlights the importance of detailed characterization strategies to support the quality assessment of RNA therapeutics. Check here for more: https://lnkd.in/ectX4Dic Thank you, Jérémie Parot, Dora Mehn, Hanna Jankevics Jones, Natalia Markova, Michele Carboni, Camilla Olaisen, Andrea Draget Hoel, Margret Asa Sigfusdottir, Florian Meier, Roland Drexel, Gabriele Vella, Birgitte Hjelmeland McDonagh, Hansen Terkel, Thanh-Huong Bui, Geir Klinkenberg, Torkild Visnes, sabrina gioria, Patricia Urban Lopez, Adriele Prina Mello, Sven Even F. Borgos, Luigi Calzolai.

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