NanoVation Therapeutics™’s Post

Name: NanoVation Therapeutics™ on LinkedIn: #crs2024 #biotech #innovation #lnp #genedelivery #geneediting #rna…
Uploaded: 2024-07-16T15:00:04.486Z
Channel: NanoVation Therapeutics™

NanoVation Therapeutics™

8,059 followers

3mo

CRS 2024 Annual Meeting Highlights Last week, the Controlled Release Society (CRS) awarded our CEO, Dominik Witzigmann, PhD, the 2024 CRS Senior Investigator Award. He also delivered an insightful talk on "Gene Delivery and Gene Editing." Special thanks to Amanda Bray, Tara Locantore, and colleagues for bringing together these brilliant minds. We also extend our gratitude to AstraZeneca for co-sponsoring the Workshop on "Therapeutic Genome Editing." Looking forward to the 2025 CRS Annual Meeting in Philadelphia! #CRS2024 #Biotech #Innovation #LNP #GeneDelivery #GeneEditing #RNA #NanoVationTherapeutics

Transcript

Thanks a lot to the CRS Gene Delivery and Gene Editing Focus group for awarding me the Senior Investigator Award. I feel incredibly honored and this propelled forward my deep motivation to make an impact. I would like to take a few minutes to talk about the past, the present and the future. In the past our field had made incredible discoveries and was really focused on the one fit all approach, how to take one type of lamp and apply to different applications. This had culminated in the first ever as Irony therapeutic called on Petro for treating Frank Claritin induced amyloidosis as well as the incredibly potent COVID-19 mRNA vaccine. What we should not forget that there are many decades of research behind that and I highly recommend the recent perspective from Peter and Phil on the 60 year of evolution of lipid nanoparticle technology enabling nucleic acids therapy. The question is now how do we apply the knowledge we have games to new technologies and go beyond vaccines and beyond the liver? And this is really about Novation Therapeutics and development and rational design of fit for purpose lipid nanoparticles. I would just like to give you 3 examples. X vivo del therapies. We have developed incredibly potent lamps which allow highly efficient knockout as well as knock in. At a very favorable safety profile. Second back theme, we have developed the so-called Peclet LP, which is highly stable and enables incredibly interesting applications for infectious disease and other type of vaccines. And loved the Tamic administration. How can we target tissues beyond the liver? And we have developed the so-called long circulating LNP technology, our collective LNP technology, which helps traumatically increased stipulated lifetimes of blood while still being transfection potent and therefore enabling the targeting of extrahepatic tissues like the bone marrow to transfect hematopoietic stem cells, P cells then critic cells in various different extrahepatic tissues. So what about the future? And there I would like to focus on making an impact. How can we translate all the technology? To the clinic. And potentially also develop even more personal like the broaches like personalized cancer vaccines or greeting monogenic diseases with private mutation in a highly personalized manner. And what we should not forget here, and I want to end with a vote, is nothing is more important than patient. Don't ever forget that. It's unavoidable that you, your partner, your kids at one day become a patient and this is that moment when you. Walk clearly, Realize what impact you can make. With this. Thanks a lot again to the theory and the theory focus group on line delivery and gene editing forwarding me the Senior Again Investigator Award. Thank you.

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