National Cancer Institute (NCI)’s Post

The biggest version of science is to benefit humanity, and I strongly believe that the next important area to work on for this century would be the reduction of greenhouse gases and protecting humanity from the global environmental disaster. Note: CO2 is the leading greenhouse gas, with the contribution of nearly 80% of all greenhouse gases. #CO2Reduction #HeterogeneousCatalysis #Cleanfuels #Hydrogenstorage #Formicacid #CO2Hydrogenation #SustainableCatalysis #SingleatomCatalysis #Netzero

Science and Technology must be implemented in a sustainable manner for humanity and improving lives not just for splurging taxpayers' money. That's when the GDPs can get better!

New in JBC press: "Researchers' results demonstrate that miR-197-3p is a positive regulator of HIV-1 infectivity as it enhances the progeny virion infectivity by targeting DDX52." Learn more: https://lnkd.in/eKvNruak

Move away #nanogrippers on its way. #nanobots are redefining diagnosis to drug delivery at #cell level. This newly minted one is DNA-based #nanorobot which has four flexible fingers, each with three joints, enabling precise movement and gripping. It could block viruses from entering cells by binding to their surface proteins. The NanoGripper holds the potential to target various viruses, such as influenza, HIV, and hepatitis B. https://lnkd.in/ephErtYr

I am pleased to share the latest publication from our laboratory. The work is a direct outcome of my PhD research. Great team effort Devashish Sengupta, Madhu Rai, Aradhana Singh, @Ritu Gaur The paper explores the anti-HIV effects of porphyrin-fullerene dyads.  This research successfully synthesized and characterized two hydrophilic P‐F dyads, PB3C60 and PB3C70, demonstrating significantly enhanced anti‐HIV activity, particularly under PDT conditions. These dyads were effective against HIV‐1 subtypes B and C, including resistant mutant strains, making them a promising new class of antiviral agents. https://lnkd.in/dKS5FTgt #photodynamictherapy #porphyrinfullerenedyads #antiHIVAgents #organicsynthesis #porphyrins #porphyrinfullerenedyads #medicinalchemistry

1. Researchers at the University of Illinois Urbana-Champaign developed a DNA-based nanorobot called the NanoGripper, inspired by a human hand. 2. The NanoGripper has four fingers that can capture COVID-19 viruses for rapid detection and block viral entry into cells. 3. It uses strong, flexible, and programmable DNA, with a novel design that allows both static and moving parts to be created in one step. 4. Each finger has three joints for precise movement, equipped with DNA aptamers to recognize and bind to specific targets like the COVID-19 virus’s spike protein. 5. When binding to the virus, the fingers wrap around it, and the opposite side can attach to surfaces for various biomedical applications. 6. The NanoGripper can facilitate a rapid COVID-19 test, providing results in 30 minutes with sensitivity comparable to standard PCR tests. 7. It can also prevent viral infections by blocking viruses from entering cells, demonstrated in cell culture experiments. 8. Potential applications include creating an anti-viral nasal spray to prevent respiratory viruses from interacting with nasal cells, with possibilities to target other viruses like influenza and HIV.

June begins, and with it, the acknowledgement of another brilliant woman. Françoise Barré-Sinoussi changed the direction of her research in the 80's during the AIDS epidemic, and focused on answering a crucial question: whether the disease - yet without a name - was caused by a retrovirus. Her pivotal work led to the discovery of the #HIV, as the virus causing #AIDS Her work earned her the 2008 Nobel Prize in Physiology or Medicine, shared with #LucMontagnier, greatly contributing to developing the diagnose and treatment of the #disease, saving lives and breaking down the stigma and social prejudice against AIDS patients. #artwork #womeninscience #historyofscience #nobelprize #epidemic #virology #FrançoiseBarréSinoussi #artscience #illustration #scientificillustration #portraits #SciWo24 #digitaldesign #historyofmedicine

Beautiful image uploaded by my fellow Eloy Mata MD Instituto Mexicano de Oftalmología I.A.P. Cytomegalovirus retinitis of a 40-year-old male with positive HIV history. He presented with CD4 cell count of 50 cells/mm3 and decreased vision of left eye. In the photograph we can see the three typical patterns in this retinitis: a hemorrhagic appearance in superior temporal arcade and between nasal arcades, granular pattern in superior temporal retina, and a “frosted branch” angiitis surrounding the retinal vessels in nasal and superior retina. https://lnkd.in/g8kiQ4b4

NIEHS Senior Scientist Shyamal Peddada, Ph.D., received an NIH Office of AIDS Research Innovation Award to improve understanding of the gut microbiome and antimicrobial resistance in persons with HIV. Antimicrobial resistance, which is on the rise worldwide due to various factors, such as infections, antibiotics, radiation, and climate change, occurs when germs become able to defeat antibiotics designed to kill them. Read more at https://bit.ly/3AriN1Z #NIEHSFactor

Gladstone scientists are harnessing the potential of artificial intelligence to probe the depths of massive data sets and discover cures for humankind’s most devastating diseases, including Alzheimer’s, Parkinson’s, heart failure, HIV, diabetes, and cancer. Learn how you can join us on the journey at Gladstonenow.org