Nature Research Custom Media’s Post

Structural basis of mRNA decay by the human exosome–ribosome supercomplex https://lnkd.in/gh42PF5x

Check out this paper by the team at Regeneron! "Comprehensive chromatographic assessment of forced degraded in vitro transcribed mRNA"

This is the pdf for force deg of mRNA

Fascinating new research on branched mRNA molecules! This article discusses how scientists are creating new types of mRNA molecules that could be used in vaccines and therapies. These branched mRNA molecules last longer and are translated more efficiently, potentially allowing for lower medicine doses. #medicine #science #research

This paper should be a great resource for mRNA design. The use of NanoLuc as a test reporter allows sensitive detection of the impact of sequence variations. https://lnkd.in/gnBnKi9U

🚀 Transforming mRNA Therapy with Advanced Microfluidics Technology 🚀 At #uBriGene, we are redefining the landscape of mRNA therapy through our cutting-edge microfluidics technology. Our approach addresses the core challenges in mRNA development: 🔬 Stabilized mRNA: Our #microfluidic systems enable LNPs to encapsulate and protect mRNA from nuclease degradation, ensuring enhanced stability. 🎯 Targeted Delivery Systems: We engineer LNPs to deliver mRNA payloads directly into the cytoplasm, boosting the efficiency of the translational process. 🔓 Endosomal Release: Our technology facilitates the crucial escape of mRNA from endosomes, maximizing its functionality. 🛡️ Reduced Immunogenicity: Optimized mRNA constructs minimize immune responses, promoting both safety and efficacy in therapeutic applications. Discover how uBriGene is pushing the boundaries of innovation in #mRNAtherapy. Together, we’re making breakthroughs that matter. #geneediting #LNPencapsulation

Really thorough work characterizing RNA LNPs.  Glad that so much more depth of analysis is being applied to the field. https://lnkd.in/eAPVwzqD

Great overview of analytical methods characterizing mRNA impurities that came out today.

Webinar: Genetic analysis for mRNA sequence confirmation and identity testing https://buff.ly/3ZqgJ4M In this recorded webinar our speaker reviews key benefits of Sanger sequencing in mRNA therapeutic and vaccine manufacturing.

Don't worry if you are new to the mRNA world, you're fashionably on time for the innovation opportunities! There are still many areas in mRNA-LNP industry with significant potential for innovation and growth that have not yet been fully explored or capitalized on. Here are a few examples: ➡ While mRNA-LNP delivery systems have shown great promise, there is still room for improvement in terms of enhancing delivery efficiency, target specificity, stability and safety. ➡ Despite significant progress, there is still a need to optimize the safety profile of LNPs, particularly concerning potential immune responses, cytotoxicity, and off-target effects. ➡ Developing imaging techniques, such as near-infrared fluorescence imaging or magnetic resonance imaging, that can visualize and track LNPs in real-time will improve our understanding of LNP behavior in living organisms and help monitor the biodistribution, pharmacokinetics, and pharmacodynamics of LNPs. ➡ There is growing interest in combining LNPs with immunomodulatory agents, such as adjuvants or immune checkpoint inhibitors, to enhance the efficacy of nucleic acid-based vaccines and immunotherapies. ➡ Developing scalable manufacturing processes and tailored formulations can accommodate individual patient characteristics and therapeutic needs. ➡ Addressing the challenges associated with the clinical translation of LNP-based therapies, including scalability, reproducibility, and regulatory considerations. There's a significant imperative to explore these areas that require improvement and have the potential to transform mRNA therapy approaches for the better. What are the other white spaces you can add to this list? #mRNA #LNP #Innovation #Whitespaces #mRNAtherapy