Navignostics AG’s Post

Stop by our booth at #AACR24 and learn more about accelerating your cancer research!

This past Friday, I had the opportunity to share the results of my summer research with the Tien Group at the 27th annual Undergraduate Research Symposium. My research includes engineering tumor-on-a-chip models to study microscopic breast cancer tumor growth in an obesity-simulated microenvironment. I described the significant difference my team and I found in the microtumors' invasion into the surrounding engineered collagen gel in "obese" and "lean" tumor environments. I was also able to share a new method we found that allowed our in vitro model to more accurately mimic tissue and flow in the human body. My next step is to discover why tumors in an obesity-simulated microenvironment are invading sooner than tumors in a control ("lean") microenvironment.

🌸 In recognition of #BreastCancerAwarenessMonth, we’re highlighting Dr. Heather Machado’s groundbreaking work at Tulane University School of Medicine. 🌸 Heather Machado, PhD, is an Associate Professor of Biochemistry and Molecular Biology and Assistant Dean for the Biomedical Sciences Graduate Program. Her research focuses on understanding the mechanisms behind mammary gland development and how these processes are disrupted in breast cancer. Dr. Machado is also dedicated to mentoring the next generation of scientists. Discover her impactful work in this episode of #TulaneMedInsider! #BreastCancerAwareness #BreastCancerResearch #Biochemistry #MolecularBiology #BiomedicalSciences

New paper out! Happy to share our publication on co-axial hydrogel manipulation for the facile biofabrication of prostate cancer-like 3D models! An international collaboration between 3B´s Research Group, Stanford University and UCLA! We tried to answer the challenge of having stable glandular cancer-like 3D architectures that could be cultured and manipulated in the laboratory as a more physiological model of human cancer, to test and discover new drugs while reducing the need for animals - and to do it in a simple, fast and inexpensive way! This is also the last piece of the puzzle directly connected to my research period at Stanford (for now at least!) Accepted manuscript online now in Biofabrication: (https://lnkd.in/dm8KQeMR)

The 7th edition of the International Curie Course on Computational Systems Biology of Cancer is open for registrations. This edition will particularly focus on spatial multimodal data analysis. https://lnkd.in/gqBiCMH4

All #NRG2024 attendees - Mark your calendars for the Translational Committee's session "The Role of Spatial Biology in Oncology: Opportunities & Challenges for Translational Research" with this great speaker lineup!

A QUICK EXCURSION ON PROTEIN SYNTHESIS

📢New publication from the Turing-Roche partnership! Our partnership team members Anthony Baptista, Dr. Christopher Banerji, MD, PhD and Ben MacArthur have a new paper ‘Charting cellular differentiation trajectories with Ricci flow’ out in Nature Communications- https://lnkd.in/e9PDXaQH The Turing-Roche partnership is a 5 year collaboration aiming to generate insights into patient and disease heterogeneity through advanced analytics, ultimately with the goal of improving clinical care.  https://lnkd.in/gCKF5dRk The paper details the development of new methods, using tools from geometry, to better understand tissue repair/regeneration and cancer development. These methods can allow us to better predict individual risk profiles and provide strategies for therapy, as well as being general enough to be applied to other opaque systems where explainability/interpretability is required. Chris has written an accompanying blog which tells the history of geometry and how these approaches that were popularised in general relativity are now being utilised in cancer biology. Check it out here: https://lnkd.in/eeVfq3cH

Do want to know more about Miltenyi spatial multi-omics solution? Come here check link🤩

DNA plays a crucial role in the development and progression of cancer. While there are many factors involved in cancer development, changes to the cellular DNA arising from DNA damage is a basic driver of multiple human diseases. Structural biology focuses on understanding the three-dimensional (3D) structures of biomolecules, as well as how these structures function and interact with each other during cellular processes. Using the latest technologies, structural biologists like Bret Freudenthal, PhD, can investigate every nook and cranny of molecular structures. Learn more about Dr. Freudenthal's research lab in the latest edition of our annual publication, Beyond the Bench ➜ https://bit.ly/4bIRUnE.