NeoGenomics Laboratories’ Post

Good opportunity

Excellent contribution to the field of #sensors and carbon #nanotubes platforms.

Today, we are happy to welcome Maitê Silva Martins Marçal, who is starting her PhD thesis in our team. Maitê comes from Brazil and was studying biomedical engineering at the UFPA-Federal University of Pará - Cametá Campus, and has already done her M2 internship with us. She will work under the supervision of benjamin lemasson and Thomas Christen on the development of new #AI-based tools to generate realistic vascular networks for MR Fingerprinting (#MRF). 🧠 More specifically, her thesis aims to improve #MRI imaging by developing realistic biophysical simulations and integrating #artificialintelligence tools within the MRF framework. By combining in vivo acquisitions with digital simulations based on #NMR physics and biophysics, the goal is to simultaneously access multiple MRI parameters, quantify them, and extract information about tissue microstructures.

I'm pleased to have wrapped up my 10-week #biophysics internship with the Mao lab at the Laboratory for Molecular Cell Biology, UCL. My deepest appreciation for my supervisor Giulia Paci, who taught me so much about research, PhDs and a career in academia. Thank you to Yanlan Mao and everyone in the lab for such a wonderful learning experience! I really enjoyed the interdisciplinary environment where people from different backgrounds bring different skills to the table. My project is about how cells in a fruit fly's wing disc acquire specialised fate and become sensory hairs, forming intricate patterns. More specifically, I investigated how we can genetically perturb cell shape and cell-cell contacts, hence affecting the pattern of specialised cells. I was curious about how physicists really contribute to biology research. Through this internship, I gained a concrete understanding of how physicists bring unique skills to interdisciplinary research, making me more confident in pursuing it further. Here are some physics moments 1. Building and optimising instruments: It is fascinating to learn the physics behind two-photon microscopy used for imaging wing discs, and how it yields higher image quality than one-photon microscopy. The wing disc we imaged stretched the microscope to its limits, meaning we had to think about the effect of changing lens, microscope parameters and sample mounting technique on image quality. I also learnt how improving some aspects of the image (e.g. depth) can compromise other aspects (e.g. spatial resolution) because of the optics. 2. Physics in biological systems: I had great chats with lab members about their research. One lab member is developing models for tissue recoil based on fluid properties to study wound healing. Another is working on modelling cell shape with vertex models, which can involve force/energy equations. Talking to them has sparked my interest in this type of research. 3. Quantitative skills: I quantified cell shape, distilling insights aggregated from complex data. I also assessed the effectiveness of algorithms we used. It is one thing to say a cell is wiggly, but another to say HOW wiggly😅. 4. Mindset: physicists approach problems differently from biologists. Cell fate specification -> spontaneous symmetry breaking. Lateral inhibition -> positive feedback loop. Wiggliness of cells -> curvature (i.e. second derivative). Also, optimisation problems with constraints are literally everywhere.

SHOTGUN SEQUENCING Shotgun sequencing is a laboratory technique for determining the DNA sequence of an organism’s genome. The method involves randomly breaking up the genome into small DNA fragments that are sequenced individually. A computer program looks for overlaps in the DNA sequences, using them to reassemble the fragments in their correct order to reconstitute the genome. National Human Genome Research Institute (NHGRI) #biotechnology #bioinformatics #linkedin #researchanddevelopment #research #internship #innovation #leadership #summerinternship #opentowork #career #jobs #hiring #technology #training #networking #entrepreneurship #neuroscience

✨ Wrapping up an unforgettable summer internship at the Human Genetics & Therapeutics Lab at KAUST Smart-Health Initiative ✨ This summer, I traded my stethoscope for a pipette and dived into the fascinating world of cell biology and molecular medicine. Working on a project involving children with osteogenesis imperfecta (OI) and exploring a rare variant in the TAPT1 gene was both challenging and eye-opening. It completely flipped the script on how I understand diseases, allowing me to see them not just from a clinical perspective, but at the molecular and cellular levels. 🌱🔬 Connecting the dots between what I’ve learned in medicine and these advanced lab techniques has given me a richer, deeper understanding of how complex diseases work. I got hands-on with some pretty cool techniques: • 🧫 Aseptic cell culture • ❄️ ⁠Freezing and thawing cells • 🔬 ⁠Mycoplasma testing • 🧪 ⁠Plasmid DNA Purification • 💪 Protein extraction • 🧬 ⁠Genotyping by PCR • 🖇️ ⁠Western blotting A huge thank you to Professor Bruno REVERSADE and Aljohara Alotaibi for their guidance and support throughout this journey—I’m deeply grateful for the opportunity to learn from both of you. And of course, the lab team—you guys made this journey not only educational but a whole lot of fun! 🚀 This internship wasn’t just a milestone in my academic journey—it was an adventure that has sparked even more excitement for the future intersection of medicine and molecular science. Here’s to new perspectives and endless possibilities! 🌟🔬 #MolecularMedicine #CellBiology #MedicalScience #HumanGenetics #KAUST

Are you passionate about cancer research and eager to work on a research project using publicly available datasets? 🌟 If “YES“, then we‘ve the perfect opportunity in store for you! 🚀 Registrations are OPEN for our upcoming webinar on “Multi-Omics Research Internship Program”. Get a chance to meet and hear directly from the mentors! 🎙️💡 📝Eligibity: Open to ALL! 📅 Date: 26 December 2023 ⏰ Time: 7:00 PM IST | 7:30 AM CST 👉 Register now to secure your spot: https://lnkd.in/dZs5uTPu. #BigData #Bioinformatics #DataScience #Programming #MachineLearning #NGS #Research #Cheminformatics #Python #Coding #Research #University #Opportunity #SkillDevelopment #Genomics #Transcriptomics #Metagenomics #PhD #Internship #Scholarship #Project #Networking #PreMed #Biomedical #Webinar #ML #Neuroscience #Biotechnology #Cancer #Publication

🌟 My lab (https://www.fnimg.iit.it/) welcomes spontaneous applications for students interested in carrying out an internship/tirocinio and/or Master thesis projects in the field of computational neuroimaging and experimental neuroscience 🧠🔬   These internships are a great chance to establish or consolidate experimental and computational neuroscience skills before moving on to postgraduate studies.    1️⃣ Regional Control of Brain Functional Connectivity: The student will employ chemogenetic methods to perturb regional cortical activity and map ensuing patterns of brain activity as measured with multiple modalities.    ➡ Requirements: interest in acquiring experimental neurobiology skills (i.e. works in rodents).  ➡ Relevant literature: https://lnkd.in/dj8JJE6E     2️⃣ Network Correlates of Behavior in the Mouse The project entails the use of multivariate methods to analyze a unique database comprising combined behavioral measurements and fMRI connectivity mapping in mice. The goal of the project is to identify and map brain/behavior associations, i.e. signatures of network activity that are predictive of behavioral traits mapped in mice.    ➡ Requirements: Solid understanding of multivariate statistics. Prior experience in coding (matlab, python or similar). ➡Relevant literature: https://lnkd.in/dFR-phKj  (this paper exemplifies some of the approaches used)    3️⃣ Noradrenergic Modulation of Brain Functional Connectivity The project encompasses the analysis of previously acquired images in mice undergoing modulation of noradrenergic activity. The goal here is to map how noradrenergic signals affect brainwide coupling in the mouse.     ➡Requirements: Solid understanding of statistics. Prior experience in coding (matlab, python or similar) is desirable.  ➡Relevant literature: https://lnkd.in/d2D44VE8   📧 Informal inquiries can be sent to: alessandro.gozzi @ iit.it 🚀 #InternshipOpportunity #MasterThesis #Neuroscience #ResearchOpportunity #IITScience 🧑🔬  

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